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The Golgi Apparatus pp 520–534Cite as

Secretion and endocytosis in endothelial cells

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Abstract

Although the cell machinery for uptake and transport of nutrients and lipids in EC follows the general routes and main rules observed in other cell types, there are several unique features that can be demonstrated in endothelial cells. This fact is due to the impact of the endothelium in the transport of proteins, glucose and lipids from blood circulation to the surrounding tissue. Furthermore, the exchange of the blood gases oxygen and carbon dioxide between capillaries and the surrounding tissues is a main task of endothelium. For this, a high specialization of microvascular architecture and function can be found in different tissues and organs (for reviews see Aird 2008; Andersson et al. 2004; Craig et al. 1998; Ekataksin and Kaneda 1999; Firth 2002; Hendrickx et al. 2004; Hudetz 1997; Lehmann et al. 2000; Levick 1995; Lim et al. 2003; Michel 1995; Ohta et al. 1992; Pittman 1995; Yano et al. 2007). A third functional aspect of endothelium is the maintenance of blood hemostasis. The constitutive as well as the regulated secretion of von Willebrand factor in relation to the posttranslational modification in the ER and in the Golgi apparatus will be discussed later in this article.

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  1. Department of Cell Biology and Ultrastructure Research Center for Anatomy and Cell Biology, Medical University of Vienna, Schwarzspanierstraße 17, 1090, Vienna, Austria

    Josef Neumüller & Adolf Ellinger

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  1. Josef Neumüller
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  1. Department of Cell Biology and Oncology, Consorzio Mario Negri Sud Laboratory of Intracellular Traffic, S. Maria Imbaro (Chieti), Italy

    Alexander A. Mironov

  2. Department of Cell Biology and Ultrastructure Research Institute of Histology and Embryology Center for Anatomy and Cell Biology, Medical University of Vienna, Vienna, Austria

    Margit Pavelka

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Neumüller, J., Ellinger, A. (2008). Secretion and endocytosis in endothelial cells. In: Mironov, A.A., Pavelka, M. (eds) The Golgi Apparatus. Springer, Vienna. https://doi.org/10.1007/978-3-211-76310-0_31

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