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Subclinical Atherosclerosis, Markers of Inflammation, and Oxidative Stress

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Book cover Ultrasound and Carotid Bifurcation Atherosclerosis

Abstract

The concept that atherosclerosis is an inflammatory disease goes back to the middle of the nineteenth century when Rudolf Virchow stated that “he felt no hesitation in admitting an inflammation of the inner arterial coat to be the starting point of the so-called atheromatous degeneration”1 and Carl von Rokitansky considered “chronic inflammation of the cellular sheet of the diseased vessel to be a secondary consecutive appearance which associated itself with the already established deposit.

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References

  1. Virchow RLK. Cellular Pathology. London: John Churchill; 1859.

    Google Scholar 

  2. Rokitansky C. A Manual of Pathological Anatomy. Philadelphia: Blanchard & Lea; 1855.

    Google Scholar 

  3. Ross R, Glomset JA. The pathogenesis of atherosclerosis. N Engl J Med. 1976;295:369–377.

    Article  PubMed  CAS  Google Scholar 

  4. Ross R, Glomset JA. The pathogenesis of atherosclerosis. N Engl J Med. 1976;295:420–425.

    Article  PubMed  CAS  Google Scholar 

  5. Hansson GK. Inflammation, atherosclerosis, and coronary artery disease. N Engl J Med. 2005;352:1685–1695.

    Article  PubMed  CAS  Google Scholar 

  6. Andersson J, Libby P, Hansson GK. Adaptive immunity and atherosclerosis. Clin Immunol. 2010;134(1):33–46.

    Article  PubMed  CAS  Google Scholar 

  7. Van Campenhout A, Golledge J. Osteoprotegerin, vascular calcification and atherosclerosis. Atherosclerosis. 2009;204:321–329.

    Article  PubMed  Google Scholar 

  8. Danesh J et al. C-reactive protein and other circulating markers of inflammation in the prediction of coronary heart disease. N Engl J Med. 2004;350:1387–1397.

    Article  PubMed  CAS  Google Scholar 

  9. Fibrinogen Studies Collaboration et al. Plasma fibrinogen and the risk of major cardiovascular diseases and non-vascular mortality: meta-analysis of individual data for 151,649 adults in 31 prospective studies. JAMA. 2005;294:1799–1809.

    Article  Google Scholar 

  10. Libby P. Role of inflammation in atherosclerosis associated with rheumatoid arthritis. Am J Med. 2008;121:S21-S31.

    Article  PubMed  CAS  Google Scholar 

  11. Kiechl S et al. Chronic infections and the risk of carotid atherosclerosis. Prospective results from a large population study. Circulation. 2001;103:1064–1070.

    PubMed  CAS  Google Scholar 

  12. Knoflach M, Kiechl S, Mair A, Willeit J, Wick G. Allergic rhinitis, asthma and atherosclerosis in the Bruneck and ARMY Studies. Arch Intern Med. 2005;165:2521–2526.

    Article  PubMed  Google Scholar 

  13. Sun J et al. Mast cells promote atherosclerosis by releasing proinflammatory cytokines. Nat Med. 2007;13:719–724.

    Article  PubMed  CAS  Google Scholar 

  14. Kiechl S et al. Active and passive smoking, chronicinfections and the risk of carotid atherosclerosis. Prospective results from the Bruneck Study. Stroke. 2002;33:2170–2176.

    Article  PubMed  Google Scholar 

  15. Mazzone T, Chait A, Plutzky J. Cardiovascular disease risk in type 2 diabetes mellitus: insights from mechanistic studies. Lancet. 2008;371:1800–1809.

    Article  PubMed  CAS  Google Scholar 

  16. Markus H et al. Pro-inflammatory genes variants predispose to carotid and femoral artery atherosclerosis in the presence of pro-inflammatory risk factors and chronic infection. Stroke. 2006;37:2253–2259.

    Article  PubMed  CAS  Google Scholar 

  17. McPherson R et al. A common allele on chromosome 9 associated with coronary heart disease. Science. 2007;316:1488–1491.

    Article  PubMed  CAS  Google Scholar 

  18. Ye S, Willeit J, Kronenberg F, Xu Q, Kiechl S. Association of genetic variation on chromosome 9p21 with susceptibility and progression of atherosclerosis – a prospective study. J Am Coll Cardiol. 2008;52:378–384.

    Article  PubMed  CAS  Google Scholar 

  19. Wiedermann CI et al. Association of endotoxemia with carotid atherosclerosis and cardiovascular disease. Prospective results from the Bruneck study. J Am Coll Cardiol. 1999;34:1975–1981.

    Article  PubMed  CAS  Google Scholar 

  20. Steinberg D, Parthasarathy S, Carew TE, Khoo JC, Witztum JL. Beyond cholesterol. Modifications of low-density lipoprotein that increase its atherogenicity. N Engl J Med. 1989;320:915–924.

    Article  PubMed  CAS  Google Scholar 

  21. Wick G, Knoflach M, Xu Q. Autoimmune and inflammatory mechanisms in atherosclerosis. Annu Rev Immunol. 2004;22:361–403.

    Article  PubMed  CAS  Google Scholar 

  22. Kiechl S, Wiedermann CJ, Willeit J. TLR-4 and disease. Ann Med. 2003;35:165–171.

    Article  Google Scholar 

  23. Kiechl S et al. Toll-like receptor 4 polymorphisms and atherogenesis in humans. N Engl J Med. 2002;347:185–192.

    Article  PubMed  CAS  Google Scholar 

  24. Björkbacka H et al. Reduced atherosclerosis in MyD88-null mice links elevated serum cholesterol levels to activation of innate immunity signaling pathways. Nat Med. 2004;10:416–421.

    Article  PubMed  Google Scholar 

  25. Fuster V, Badimon L, Badimon JJ, Chesebro JH. The pathogenesis of coronary artery disease and the acute coronary syndromes (1). N Engl J Med. 1992;326:242–250.

    Article  PubMed  CAS  Google Scholar 

  26. Fuster V, Badimon L, Badimon JJ, Chesebro JH. The pathogenesis of coronary artery disease and the acute coronary syndromes (2). N Engl J Med. 1992;326:310–318.

    Article  PubMed  CAS  Google Scholar 

  27. Kiechl S, Willeit J. The natural course of atherosclerosis. Part I: incidence and progression. Arterioscler Thromb Vasc Biol. 1999;19:1484–1490.

    Article  PubMed  CAS  Google Scholar 

  28. Kiechl S, Willeit J. The natural course of atherosclerosis. Part II: vascular remodeling. Arterioscler Thromb Vasc Biol. 1999;19:1491–1498.

    Article  PubMed  CAS  Google Scholar 

  29. Willeit J et al. Distinct risk profiles of early and advanced atherosclerosis. Prospective results from the Bruneck study. Arterioscler Thromb Vasc Biol. 2000;20:529–537.

    Article  PubMed  CAS  Google Scholar 

  30. Kiechl S, Willeit J, Egger G, Poewe W, Oberhollenzer F. Body iron stores and the risk of carotid atherosclerosis. Prospective results from the Bruneck study. Circulation. 1997;96:3300–3307.

    PubMed  CAS  Google Scholar 

  31. Glagov S, Weisenberg E, Zarins CK, Stankunavicius R, Kolettis GJ. Compensatory enlargement of human atherosclerotic coronary arteries. N Engl J Med. 1987;316:1371–1375.

    Article  PubMed  CAS  Google Scholar 

  32. Tsimikas S et al. Lipoprotein-associated phospholipase A2 activity, ferritin levels, metabolic syndrome and 10-year cardiovascular and non-cardiovascular mortality: results from the Bruneck study. Eur Heart J. 2009;30:107–115.

    Article  PubMed  CAS  Google Scholar 

  33. Kiechl S et al. Oxidized phospholipids, lipoprotein(a), lipoprotein-associated phospholipase A2 activity and 10-year cardiovascular outcomes: prospective results from the Bruneck study. Arterioscler Thromb Vasc Biol. 2007;27:1788–1795.

    Article  PubMed  CAS  Google Scholar 

  34. The Emerging Risk Factors Collaboration. Lipoprotein(a) concentration and the risk of coronary heart disease, stroke and nonvascular mortality. Individual data analysis of 121,944 participants from 34 cohorts. JAMA. 2009;302:412–423.

    Article  Google Scholar 

  35. Zacharski LR et al. Reduction of iron stores and cardiovascular outcomes in patients with peripheral arterial disease: a randomized controlled trial. JAMA. 2007;297:603–610.

    Article  PubMed  CAS  Google Scholar 

  36. Davidson MH et al. Consensus panel recommendation for incorporating lipoprotein-associated phospholipase A2 testing into cardiovascular disease risk assessment guidelines. Am J Cardiol. 2008;101:51F-57F.

    Article  PubMed  CAS  Google Scholar 

  37. Kiechl S et al. The OPG/RANK/RANKL system – a bone key to vascular disease. Expert Rev Cardiovasc Ther. 2006;4:801–811.

    Article  PubMed  CAS  Google Scholar 

  38. Collin-Osdoby P. Regulation of vascular calcification by osteoclast regulatory factors RANKL and osteoprotegerin. Circ Res. 2004;95:1046–1057.

    Article  PubMed  CAS  Google Scholar 

  39. Kiechl S et al. Soluble receptor activator of nuclear factor-κB ligand (RANKL) and risk of cardiovascular disease. Circulation. 2007;116:385–391.

    Article  PubMed  CAS  Google Scholar 

  40. Kiechl S et al. Osteoprotegerin is a risk predictor of progressive atherosclerosis and cardiovascular disease. Circulation. 2004;109:2175–2180.

    Article  PubMed  CAS  Google Scholar 

  41. Afzal AR et al. Common CCR5-del32 frameshift mutation associated with serum levels of inflammatory markers and cardiovascular disease risk in the Bruneck population. Stroke. 2008;39:1972–1978.

    Article  PubMed  CAS  Google Scholar 

  42. Willeit J et al. The Marburg I polymorphism of factor VII activating protease: a prominent risk predictor of arterial thrombosis. Circulation. 2003;107:667–670.

    Article  PubMed  CAS  Google Scholar 

  43. Knoflach M et al. Cardiovascular risk factors and atherosclerosis in young women – ARFY study (Atherosclerosis Risk-Factors in Female Youngsters). Stroke. 2009;40:1063–1069.

    Article  PubMed  CAS  Google Scholar 

  44. Knoflach M et al. Vascular risk factors and atherosclerosis in young males – ARMY study (Atherosclerosis Risk-Factors in Male Youngsters). Circulation. 2003;108:1064–1069.

    Article  PubMed  Google Scholar 

  45. Xu Q et al. Serum soluble heat shock protein 60 is elevated in subjects with atherosclerosis in a general population. Circulation. 2000;102:14–20.

    PubMed  CAS  Google Scholar 

  46. Xu Q et al. Association of serum antibodies to heat-shock protein 65 with carotid atherosclerosis. Lancet. 1993;341:255–259.

    Article  PubMed  CAS  Google Scholar 

  47. Brouilette SW et al. Telomere length, risk of coronary heart disease, and statin treatment in the West of Scotland primary prevention study: a nested case-control study. Lancet. 2007;369:107–114.

    Article  PubMed  CAS  Google Scholar 

  48. Panayiotou A et al. Leukocyte telomere length is associated with measures of subclinical atherosclerosis. Atherosclerosis. 2010;211(1):176–181.

    Article  PubMed  CAS  Google Scholar 

  49. Willeit P et al. Cellular aging reflected by leukocyte telomere length predicts advanced atherosclerosis and cardiovascular disease risk. Arterioscler Thromb Vasc Biol. 2010;30:1649–1656.

    Article  PubMed  CAS  Google Scholar 

  50. Jaffer FA, Libby P, Weissleder R. Optical and multimodality molecular imaging: insights into atherosclerosis. Arterioscler Thromb Vasc Biol. 2009;29:1017–1024.

    Article  PubMed  CAS  Google Scholar 

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Kiechl, S., Werner, P., Knoflach, M., Willeit, J. (2011). Subclinical Atherosclerosis, Markers of Inflammation, and Oxidative Stress. In: Nicolaides, A., Beach, K., Kyriacou, E., Pattichis, C. (eds) Ultrasound and Carotid Bifurcation Atherosclerosis. Springer, London. https://doi.org/10.1007/978-1-84882-688-5_28

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  • DOI: https://doi.org/10.1007/978-1-84882-688-5_28

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