Abstract
The Collaborative Transplant Study (CTS) was initiated in 1982 in Heidelberg, Germany, and originated from the need to gain further insight into the complex problems and risks involved in human organ transplantation. Currently, more than 400 transplant centers in 45 countries are contributing to this voluntary international effort, and from the beginning of the study, the impact on graft outcome of immunological factors, such as matching for HLA antigens and allosensitization to HLA and non-HLA antigens, have been areas of interest. Herein, we summarize the recent findings from the CTS on these two topics.
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References
Mange KC et al (2001) A comparison of the survival of shipped and locally transplanted cadaveric renal allografts. N Engl J Med 345:1237–1242
Collaborative Transplant Study, University of Heidelberg, Germany, Website. www.ctstransplant.org. Accessed 29 Nov 2010
Opelz G, Döhler B (2007) Multicenter analysis of kidney preservation. Transplantation 83:247–253
Opelz G, Döhler B (2007) Effect of human leukocyte antigen compatibility on kidney graft survival: comparative analysis of two decades. Transplantation 84:137–143
Opelz G, Döhler B (2010) Impact of HLA mismatching on incidence of posttransplant non-Hodgkin lymphoma after kidney transplantation. Transplantation 89:567–572
Opelz G, Döhler B (2010) Association of mismatches for HLA-DR with incidence of posttransplant hip fracture in kidney transplant recipients. Transplantation 91:65–69
Meier-Kriesche HU et al (2009) A lifetime versus a graft life approach redefines the importance of HLA matching in kidney transplant patients. Transplantation 88:23–29
Opelz G et al (2010) Impact of HLA compatibility on lung transplant survival and evidence for an HLA restriction phenomenon: a collaborative transplant study report. Transplantation 90:912–927
Opelz G, Döhler B (2010) Pediatric kidney transplantation: analysis of donor age, HLA match, and posttransplant non-Hodgkin lymphoma: a collaborative transplant study report. Transplantation 90:292–297
Nikkel LE et al (2009) Risk of fractures after renal transplantation in the United States. Transplantation 87:1846–1851
O’Shaughnessy EA et al (2002) Risk factors for fractures in kidney transplantation. Transplantation 74:362–366
Vautour LM et al (2004) Long-term fracture risk following renal transplantation: a population-based study. Osteoporos Int 15:160–167
Patel S et al (2001) Prevalence and causes of low bone density and fractures in kidney transplant patients. J Bone Miner Res 16:1863–1870
Opelz G et al (1999) HLA compatibility and organ transplant survival. Collaborative Trans-plant Study. Rev Immunogenet 1:334–342
Süsal C, Pelzl S, Opelz G (2003) Strong human leukocyte antigen matching effect in nonsensitized kidney recipients with high pretransplant soluble CD30. Transplantation 76:1231–1232
Süsal C, Döhler B, Opelz G (2009) Presensitized kidney graft recipients with HLA class I and II antibodies are at increased risk for graft failure: a Collaborative Transplant Study report. Hum Immunol 70:569–573
Opelz G et al (1981) Lymphocytotoxic antibody responses to transfusions in potential kidney transplant recipients. Transplantation 32:177–183
El-Awar N et al (2002) Almost all patients who are waiting for a regraft of a kidney transplant have anti-HLA antibodies. Transplant Proc 34:2531–2532
Opelz G, Collaborative Transplant Study (2005) Non-HLA transplantation immunity revealed by lymphocytotoxic antibodies. Lancet 365:1570–1576
Zou Y et al (2006) Detection of anti-MICA antibodies in patients awaiting kidney transplantation, during the post-transplant course, and in eluates from rejected kidney allografts by Luminex flow cytometry. Hum Immunol 67:230–237
Terasaki PI, Ozawa M (2005) Predictive value of HLA antibodies and serum creatinine in chronic rejection: results of a 2-year prospective trial. Transplantation 80:1194–1197
Breimer ME et al (2009) Multicenter evaluation of a novel endothelial cell crossmatch test in kidney transplantation. Transplantation 87:549–556
Reinsmoen NL et al (2010) Anti-angiotensin type 1 receptor antibodies associated with antibody mediated rejection in donor HLA antibody negative patients. Transplantation 90:1473–1477
Morath C et al (2010) An integrative approach for the transplantation of high-risk sensitized patients. Transplantation 90:645–653
Fuggle SV, Martin S (2008) Tools for human leukocyte antigen antibody detection and their application to transplanting sensitized patients. Transplantation 86:384–390
Süsal C, Döhler B, Opelz G (2009) Presensitized kidney graft recipients with HLA class I and II antibodies are at increased risk for graft failure: a Collaborative Transplant Study report. Hum Immunol 70:569–573
Patel R, Terasaki PI (1969) Significance of the positive crossmatch test in kidney transplantation. N Engl J Med 280:735–739
Opelz G, Döhler B, Süsal C (2009) Analysis of positive kidney, heart, and liver transplant crossmatches reported to the Collaborative Transplant Study. Hum Immunol 70:627–630
Bingaman AW et al (2008) A virtual crossmatch protocol significantly increases access of highly sensitized patients to deceased donor kidney transplantation. Transplantation 86:1864–1868
Ettenger RB et al (1979) Long-term cadaver allograft survival in the recipient with a positive B lymphocyte crossmatch. Transplantation 27:315–318
Hourmant M et al (1990) Effect of positive crossmatch against donor B lymphocytes in kidney transplantation: a prospective one center study. Clin Transpl 301–309
Bryan CF et al (2007) Renal graft survival is not influenced by a positive flow B-cell crossmatch. Clin Transpl 21:72–79
Magee CC et al (2008) Renal transplantation in patients with positive lymphocytotoxicity crossmatches: one center’s experience. Transplantation 86:96–103
Kerman RH et al (1990) Improved graft survival for flow cytometry and antihuman globulin crossmatch-negative retransplant recipients. Transplantation 49:52–56
Christiaans MH et al (1996) No advantage of flow cytometry crossmatch over complement dependent cytotoxicity in immunologically well-documented renal allograft recipients. Transplantation 62:1341–1347
Swinnen LJ et al (1990) Increased incidence of lymphoproliferative disorder after immunosuppression with the monoclonal antibody OKT3 in cardiac-transplant recipients. N Engl J Med 323:1723–1728
Opelz G, Henderson R (1993) Incidence of non-Hodgkin lymphoma in kidney and heart transplant recipients. Lancet 342:1514–1516
Opelz G, Döhler B (2004) Lymphomas after solid organ transplantation: a Collaborative Transplant Study report. Am J Transplant 24:222–230
Acknowledgments
We gratefully acknowledge the generous support of the staff members at participating CTS centers.
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Süsal, C., Opelz, G. (2012). Impact of HLA Matching and HLA Antibodies in Organ Transplantation: A Collaborative Transplant Study View. In: Christiansen, F., Tait, B. (eds) Immunogenetics. Methods in Molecular Biology, vol 882. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-61779-842-9_15
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DOI: https://doi.org/10.1007/978-1-61779-842-9_15
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