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Lacrimal Gland, Tear Film, and Dry Eye Syndromes 2 pp 453–460Cite as

Apoptosis in the Lacrimal Gland and Conjunctiva of Dry Eye Dogs

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Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 438))

Abstract

Keratoconjunctivitis sicca (KCS), or dry eye syndrome, is characterized by the development of ocular surface damage. KCS can occur as an individual phenomenon, or in association (as a secondary phenomenon) with various types of systemic autoimmune disorders. Sjögren’s syndrome (SS), with the signature symptoms of dry eye and dry mouth, has the strongest association with KCS. The most prominent characteristic of SS is a progressive, follicular, lymphoid infiltration found in biopsy specimens of the lacrimal and salivary glands. These infiltrates consist of primarily CD4+ T cells and B cells demonstrated by immunohistological staining. Functional studies have shown that this type of impairment of the lacrimal gland results in decreased tear secretion and altered tear protein composition.1

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Authors and Affiliations

  1. Department of Biological Science, Allergan, Inc, Irvine, California, USA

    Jianping Gao, Tammy A. Gelber-Schwalb, John V. Addeo & Michael E. Stern

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  1. Jianping Gao
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  2. Tammy A. Gelber-Schwalb
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  3. John V. Addeo
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  4. Michael E. Stern
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Editor information

Editors and Affiliations

  1. The Schepens Eye Research Institute, Harvard Medical School, Boston, Massachusetts, USA

    David A. Sullivan  & Darlene A. Dartt  & 

  2. Louisiana State University Medical Center, New Orleans, Louisiana, USA

    Michele A. Meneray

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© 1998 Springer Science+Business Media New York

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Gao, J., Gelber-Schwalb, T.A., Addeo, J.V., Stern, M.E. (1998). Apoptosis in the Lacrimal Gland and Conjunctiva of Dry Eye Dogs. In: Sullivan, D.A., Dartt, D.A., Meneray, M.A. (eds) Lacrimal Gland, Tear Film, and Dry Eye Syndromes 2. Advances in Experimental Medicine and Biology, vol 438. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-5359-5_63

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  • DOI: https://doi.org/10.1007/978-1-4615-5359-5_63

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-7445-9

  • Online ISBN: 978-1-4615-5359-5

  • eBook Packages: Springer Book Archive

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