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New Concepts in the Pathogenesis of NIDDM pp 295–301Cite as

Hyperinsulinism and Dyslipidemias as Coronary Heart Disease Risk Factors in NIDDM

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Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 334))

Abstract

Since abnormalities of serum lipids and lipoproteins are highly prevalent in NIDDM they are considered as potential factors contributing to the increased CHD risk. On the other hand the link between hyperinsulinism and dyslipidemias is well-established although the causal relationship is not clear despite extensive studies. There is ample evidence that both conditions are associated with various metabolic abnormalities like hypertension, upper body obesity and NIDDM which are part of disease cluster named Syndrome X by Reaven1 or the so-called “deadly quartet”2. Growing evidence indicate that hypertriglyceridemia and low HDL cholesterol, which characterize insulin resistance, play a role in atherogenesis and contribute to CHD risk.

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Author information

Authors and Affiliations

  1. Third Department of Medicine, University of Helsinki, Haartmaninkatu 4, 00290, Helsinki, Finland

    Marja-Riitta Taskinen

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  1. Marja-Riitta Taskinen
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Editors and Affiliations

  1. Karolinska Hospital, Stockholm, Sweden

    Claes Göran Östenson  & Suad Efendić  & 

  2. University of Toronto, Toronto, Ontario, Canada

    Mladen Vranic

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© 1993 Springer Science+Business Media New York

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Taskinen, MR. (1993). Hyperinsulinism and Dyslipidemias as Coronary Heart Disease Risk Factors in NIDDM. In: Östenson, C.G., Efendić, S., Vranic, M. (eds) New Concepts in the Pathogenesis of NIDDM. Advances in Experimental Medicine and Biology, vol 334. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-2910-1_23

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  • DOI: https://doi.org/10.1007/978-1-4615-2910-1_23

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-6262-3

  • Online ISBN: 978-1-4615-2910-1

  • eBook Packages: Springer Book Archive

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