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Lacrimal Gland, Tear Film, and Dry Eye Syndromes 3 pp 647–655Cite as

Experimentally Induced Dry Eye Produces Ocular Surface Inflammation and Epithelial Disease

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Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 506))

Abstract

Dry eye results from decreased production, increased evaporation or decreased clearance of tears.1,2 It causes ocular irritation and ocular surface disease, termed keratoconjunctivitis sicca (KCS), that causes blurred and fluctuating vision and increases the risk of sight-threatening corneal infection and ulceration.3 The histological features of KCS are abnormal proliferation and differentiation of the ocular surface epithelium with decreased density of conjunctival goblet cells and decreased and abnormal production of mucus by the ocular surface epithelium.4 The most severe KCS develops in conditions where the ability to tear responsively to neural stimulation is lost.5–7

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Author information

Authors and Affiliations

  1. Bascom Palmer Eye Institute, University of Miami School of Medicine, Miami, Florida, USA

    Dilek Dursun, Min Wang, Dagoberto Monroy, De-Quan Li & Balakrishna L. Lokeshwar

  2. Sylvester Cancer Center and Department of Urology, University of Miami School of Medicine, Miami, Florida, USA

    Balakrishna L. Lokeshwar

  3. Allergan, Inc., Irvine, California, USA

    Michael Stern

  4. Cullen Eye Institute, Baylor College of Medicine, Houston, Texas, USA

    Stephen C. Pflugfelder

Authors
  1. Dilek Dursun
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  2. Min Wang
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  3. Dagoberto Monroy
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  4. De-Quan Li
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  5. Balakrishna L. Lokeshwar
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  6. Michael Stern
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  7. Stephen C. Pflugfelder
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Editor information

Editors and Affiliations

  1. Schepens Eye Research Institute, Boston, Massachusetts, USA

    David A. Sullivan , Darlene A. Dartt  & Rose M. Sullivan ,  & 

  2. Harvard Medical School, Boston, Massachusetts, USA

    David A. Sullivan  & Darlene A. Dartt  & 

  3. Allergan, Inc., Irvine, California, USA

    Michael E. Stern

  4. Tokyo Dental College, Chiba, Japan

    Kazuo Tsubota

  5. Ichikawa General Hospital, Chiba, Japan

    Kazuo Tsubota

  6. University of New Orleans, New Orleans, Louisiana, USA

    B. Britt Bromberg

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© 2002 Kluwer Academic/Plenum Publishers

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Dursun, D. et al. (2002). Experimentally Induced Dry Eye Produces Ocular Surface Inflammation and Epithelial Disease. In: Sullivan, D.A., Stern, M.E., Tsubota, K., Dartt, D.A., Sullivan, R.M., Bromberg, B.B. (eds) Lacrimal Gland, Tear Film, and Dry Eye Syndromes 3. Advances in Experimental Medicine and Biology, vol 506. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-0717-8_91

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  • DOI: https://doi.org/10.1007/978-1-4615-0717-8_91

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-5208-2

  • Online ISBN: 978-1-4615-0717-8

  • eBook Packages: Springer Book Archive

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