Regular ArticleMechanism of the beneficial effects of dantrolene sodium on ethanol-induced acute gastric mucosal injury in rats
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2024, Journal of Environmental ManagementEffect of allantoin on experimentally induced gastric ulcers: Pathways of gastroprotection
2018, European Journal of PharmacologyCitation Excerpt :The decrease in catalase activity can be attributed to the excessive generation of these radicals, which leads to a high consumption of this enzyme to scavenge them. The depletion of glutathione levels after an acute administration of ethanol is in accordance with previous works (Büyükokuroğlu et al., 2002; Almasaudi et al., 2016) and is probably due an increase in the formation of lipid peroxides, favoring the consumption of GSH and its oxidation to GSSG by glutathione peroxidase (Yoshikawa et al., 1997). Allantoin pretreatment prevented the depletion of GSH and restored the catalase activity.
Preparation, characterization and in vivo evaluation of a formulation of dantrolene sodium with hydroxypropyl-β-cyclodextrin
2017, Journal of Pharmaceutical and Biomedical AnalysisCitation Excerpt :These results indicate good stability during the analytical procedure, which would satisfy the requirements of the pharmacokinetic study. The developed UPLC/MS/MS method was successfully used for the pharmacokinetic study of Da in rat whole blood samples [27–29]. The mean blood concentration-time curves of pure Da and Da-HP-β-CD inclusion complex are shown in Fig. 7, and the mean pharmacokinetic parameters are listed in Table 3.
Polyphenolic content and antioxidant activity of some wild Saudi Arabian asteraceae plants
2014, Asian Pacific Journal of Tropical MedicineThe ameliorating effect of dantrolene on the morphology of urinary bladder in spinal cord injured rats
2011, Pathology Research and PracticeCitation Excerpt :The efficacy of dantrolene in treating inflammatory and anti-nociceptive disorders mediated by cytokines [19] and by arachidonic acid metabolites [11,15] has already been demonstrated. It was also proven that its antioxidant properties prevent lipid peroxidation and protect cells against the toxic effects of oxygen free radicals [9,10,41]. Furthermore, the action of this drug on the relaxation of the EUS has been previously reported and, considering that voiding is one of the natural protective mechanisms of the urinary system, it is possible that the action of dantrolene on the sphincter has major roles in this process [17,20,32].
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Corresponding author. Department of Pharmacology, Medical Faculty, Atatürk University, TR-25240, Erzurum, [email protected]