Regular ArticleFresh Vein Allograft Survival in Dogs after Cyclosporine Treatment
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Fresh Cold-Stored Vascular Allografts in Subgenicular Location: Our Experience with Rescue Endovascular Techniques
2022, Annals of Vascular SurgeryCitation Excerpt :A meta-analysis suggests that there are probably no statistically significant differences between the different types of allografts.15 Allografts are very resistant to infection, but at the same time they are antigenic and there are various studies evaluating immunosuppression and its effect on reducing antigenicity and improving the patency of reconstructions.16,17 Some studies compare the immunogenicity of cryopreserved and fresh cold-stored allografts, but the results are inconclusive.18
Long term performance evaluation of small-diameter vascular grafts based on polyvinyl alcohol hydrogel and dextran and MSCs-based therapies using the ovine pre-clinical animal model
2017, International Journal of PharmaceuticsCitation Excerpt :On the other hand, there are frequent problems associated with the use of allografts, such as the increased risk of disease transmission between individuals. Further, Oschner and co-workers studied the use of such grafts and identified that rejection was a recurring occurrence in some patients (Mingoli et al., 1996). As a matter of fact, the antigenicity of the cryopreserved grafts is not decreased by the process of cryopreservation as evidenced by in vivo studies (Moriyama et al., 2001).
Long term performance evaluation of small-diameter vascular grafts based on polyvinyl alcohol hydrogel and dextran and MSCs-based therapies using the ovine pre-clinical animal model
2016, International Journal of PharmaceuticsCitation Excerpt :On the other hand, there are frequent problems associated with the use of allografts, such as the increased risk of disease transmission between individuals. Further, Oschner and co-workers studied the use of such grafts and identified that rejection was a recurring occurrence in some patients (Mingoli et al., 1996). As a matter of fact, the antigenicity of the cryopreserved grafts is not decreased by the process of cryopreservation as evidenced by in vivo studies (Moriyama et al., 2001).
The Positive Effect of Immunosuppression on Adaptation of Venous Allografts to Arterialisation in Rats
2010, European Journal of Vascular and Endovascular SurgeryCitation Excerpt :However, given alone, neither cyclosporine A at a 10 mg kg−1 per day nor mycophenolate mofetil at 20 mg kg−1 per day improved the overall patency of venous allografts. In the work of Mingoli et al.,10 cyclosporine A at 20 mg kg−1 day reduced aneurysmal dilatation and immunological responses at 30 days following allogeneic venous transplantations in dogs. However, discontinuing cyclosporine A immunosuppression led to the occlusion of cold-stored17 as well as cryopreserved18 venous allografts within 30 days.
Cold-stored Venous Allografts in the Treatment of Critical Limb Ischaemia
2007, European Journal of Vascular and Endovascular SurgeryCitation Excerpt :Recent immunological studies have shown that venous allografts, cold-stored as well as cryopreserved, are antigenic24 and that the antigenicity is not modified by cryopreservation.25–27 Immunosuppression has been examined as a possible adjunct to decrease the antigenicity of the venous allograft, mainly in animal models.28–30 The immunosuppressive therapy after allovenous reconstructions is generally not used.
Adenoviral-mediated gene transfer of ICP47 inhibits major histocompatibility complex class I expression on vascular cells in vitro
2000, Journal of Vascular Surgery