Regular ArticleThe Ovarian Renin–Angiotensin System in Reproductive Physiology☆,☆☆
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Modelling female physiology from head to Toe: Impact of sex hormones, menstrual cycle, and pregnancy
2022, Journal of Theoretical BiologyCitation Excerpt :Indeed, some studies claim that blood pressure is the highest at the beginning of the menstrual cycle (Dunne et al., 1991), while others claim it is the highest at the end (Greenberg et al., 1985; Pechère-Bertschi et al., 2000). The relationship between the RAS and the menstrual cycle has been studied much more extensively, given that the female reproductive system contains a functional local tissue RAS (Yoshimura, 1997; Pepin É et al., 2017; Yoshimura et al., 1993; Sealey et al., 1985). Indeed, ovarian follicular cells cyclically produce and secrete prorenin (the precursor to renin) into the follicular fluid and circulation following the surge in leutinizing hormone that precedes ovulation (Sealey et al., 1985).
Proteome-wide and matrisome-specific atlas of the human ovary computes fertility biomarker candidates and open the way for precision oncofertility
2022, Matrix BiologyCitation Excerpt :At reproductive age, all matrisomal hallmarks of prepuberty have declined, and only two proteins appear to be exceptionally highly expressed in this age group: AGT and GPC6 (Fig. 2.A,C). AGT has been enriched in the renin angiotensinogen system (RAS), which is presumed to regulate oocyte maturation and quality, promote angiogenesis and lipid storage [15,16]. GPC6 is a positive regulator of cell proliferation, a paramount process for follicle development [17,18].
Potential receptors in Fenneropenaeus merguiensis ovary and role of saxophone, the bone morphogenetic protein receptor, in ovarian development
2022, Comparative Biochemistry and Physiology -Part A : Molecular and Integrative PhysiologyCitation Excerpt :Therefore, the increased Smo expression during vitellogenic stages suggests that Smo plays a role in ovarian development (Fig. 5K). The renin receptor has been implicated in the induction of meiotic resumption in oocyte maturation (Dau et al., 2016; Yoshimura, 1997) and in sperm fertility (Gianzo et al., 2021). Hence, the increase of renin receptor expression in vitellogenic stages (Fig. 5E) may indicate involvement in the ovarian maturation process.
Prediction of oocyte quality using mRNA transcripts screened by RNA sequencing of human granulosa cells
2021, Reproductive BioMedicine OnlineCitation Excerpt :Additionally, COL1A1 and COL1A2 were associated with the PI3K/Akt signalling pathway, which plays an important role in oocyte maturation (Shimada et al., 2003; Hoshino et al., 2004; Hall et al., 2018) and embryo development (Riley et al., 2005). Renin is an enzyme that catalyzes the hydrolysis of angiotensinogen to the decapeptide angiotensin I, which is a primary component of the renin-angiotensin system that plays a significant role in ovarian function, including steroidogenesis, follicular development, oocyte maturation and ovulation (Yoshimura, 1997; Palumbo et al., 2016). The level of renin in follicular fluid of women in a normal menstrual cycle increases at the preovulatory phase (days 13–14 of cycle), and gonadotrophin stimulation, increases the level of renin compared with women in a normal menstrual cycle (Palumbo et al., 2016).
Prorenin periconceptionally and in pregnancy: Does it have a physiological role?
2021, Molecular and Cellular EndocrinologyCitation Excerpt :Ang II might also display vascular effects in the follicular microcirculation (affecting blood flow) and facilitate the process of neovascularization that is required for appropriate corpus luteum formation (Fernandez et al., 1985; Stirling et al., 1990). Many of these Ang II effects are controversial (Naftolin et al., 1989; Yoshimura, 1997). Both AT1 and AT2 receptor stimulation have been implied, with the AT2 receptor being the predominant Ang II receptor in the ovaries (Yoshimura et al., 1996).
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Address correspondence and reprint requests to Yasunori Yoshimura, Department of Obstetrics and Gynecology, Keio University School of Medicine, Shinanomachi 35, Shinjuku-ku, Tokyo, Japan 160. Telephone: 3-3353-1211; Fax: 3-3352-1598; e-mail: http://[email protected].
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J, H, LaraghB, M, Brenner, Eds.