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Erschienen in: memo - Magazine of European Medical Oncology 3/2021

18.08.2021 | case report

Lethal human metavirus pneumonia in a patient with chronic lymphocytic leukemia

verfasst von: MD Holger Rumpold

Erschienen in: memo - Magazine of European Medical Oncology | Ausgabe 3/2021

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Summary

Human metapneumovirus (HMPV) causes a flu-like disease in humans. Most infections occur in early childhood, but reinfections during life are common. The clinical course of these infections are usually mild and do not require hospitalization. However, this is not the case for older and/or comorbid patients, especially if lymphoma is a concurrent disease. Here, we report on a case of an 81-year-old man, who suffered from chronic lymphocytic leukemia. During the first coronavirus disease (COVID) wave, he was admitted to the emergency department with respiratory symptoms. Initially, he was suspected as having SARS-CoV‑2 infection, but a broad diagnostic approach revealed a HMPV infection. The patient showed remarkable, bilateral pulmonary infiltrates and worsened within a few days. Consequently, he had to be admitted to the intensive care unit, where he was mechanically ventilated. Clinically, the patient worsened further and died on day 5 after admission. Severe HMPV infections are rare. However, patients suffering from hematological diseases are at high risk, which is exemplified in this case report.

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Literatur
1.
Zurück zum Zitat Hamelin MÈ, Abed Y, Boivin G. Human metapneumovirus: a new player among respiratory viruses. Clin Infect Dis. 2004;38(7):983–90. CrossRef Hamelin MÈ, Abed Y, Boivin G. Human metapneumovirus: a new player among respiratory viruses. Clin Infect Dis. 2004;38(7):983–90. CrossRef
2.
Zurück zum Zitat Peret TCT, Boivin G, Li Y, Couillard M, Humphrey C, Osterhaus ADME, et al. Characterization of human metapneumoviruses isolated from patients in North America. J Infect Dis. 2002;185(11):1660–3. CrossRef Peret TCT, Boivin G, Li Y, Couillard M, Humphrey C, Osterhaus ADME, et al. Characterization of human metapneumoviruses isolated from patients in North America. J Infect Dis. 2002;185(11):1660–3. CrossRef
3.
Zurück zum Zitat Boivin G, Abed Y, Pelletier G, Ruel L, Moisan D, Coôteé S, et al. Virological features and clinical manifestations associated with human metapneumovirus: a new paramyxovirus responsible for acute respiratory-tract infections in all age groups. J Infect Dis. 2002;186(9):1330–4. CrossRef Boivin G, Abed Y, Pelletier G, Ruel L, Moisan D, Coôteé S, et al. Virological features and clinical manifestations associated with human metapneumovirus: a new paramyxovirus responsible for acute respiratory-tract infections in all age groups. J Infect Dis. 2002;186(9):1330–4. CrossRef
4.
Zurück zum Zitat Williams JV, Harris PA, Tollefson SJ, Halburnt-Rush LL, Pingsterhaus JM, Edwards KM, et al. Human metapneumovirus and lower respiratory tract disease in otherwise healthy infants and children. N Engl J Med. 2004;350(5):443–50. CrossRef Williams JV, Harris PA, Tollefson SJ, Halburnt-Rush LL, Pingsterhaus JM, Edwards KM, et al. Human metapneumovirus and lower respiratory tract disease in otherwise healthy infants and children. N Engl J Med. 2004;350(5):443–50. CrossRef
5.
Zurück zum Zitat Van Den Hoogen BG, De Jong JC, Groen J, Kuiken T, De Groot R, Fouchier RAM, et al. A newly discovered human pneumovirus isolated from young children with respiratory tract disease. Nat Med. 2001;7(6):719–24. CrossRef Van Den Hoogen BG, De Jong JC, Groen J, Kuiken T, De Groot R, Fouchier RAM, et al. A newly discovered human pneumovirus isolated from young children with respiratory tract disease. Nat Med. 2001;7(6):719–24. CrossRef
6.
Zurück zum Zitat Afonso CL, Amarasinghe GK, Bányai K, Bào Y, Basler CF, Bavari S, et al. Taxonomy of the order Mononegavirales: update 2016. Arch Virol. 2016;161(8):2351–60. CrossRef Afonso CL, Amarasinghe GK, Bányai K, Bào Y, Basler CF, Bavari S, et al. Taxonomy of the order Mononegavirales: update 2016. Arch Virol. 2016;161(8):2351–60. CrossRef
7.
Zurück zum Zitat Howard LM, Edwards KM, Zhu Y, Griffin MR, Weinberg GA, Szilagyi PG, et al. Clinical features of human metapneumovirus infection in ambulatory children aged 5–13 years. J Pediatric Infect Dis Soc. 2018;7(2):165–8. CrossRef Howard LM, Edwards KM, Zhu Y, Griffin MR, Weinberg GA, Szilagyi PG, et al. Clinical features of human metapneumovirus infection in ambulatory children aged 5–13 years. J Pediatric Infect Dis Soc. 2018;7(2):165–8. CrossRef
8.
Zurück zum Zitat Van Den Hoogen BG, Van Doornum GJJ, Fockens JC, Cornelissen JJ, Beyer WEP, De Groot R, et al. Prevalence and clinical symptoms of human metapneumovirus infection in hospitalized patients. J Infect Dis. 2003;188(10):1571–7. CrossRef Van Den Hoogen BG, Van Doornum GJJ, Fockens JC, Cornelissen JJ, Beyer WEP, De Groot R, et al. Prevalence and clinical symptoms of human metapneumovirus infection in hospitalized patients. J Infect Dis. 2003;188(10):1571–7. CrossRef
9.
Zurück zum Zitat Hamelin MÈ, Prince GA, Boivin G. Effect of ribavirin and glucocorticoid treatment in a mouse model of human metapneumovirus infection. Antimicrob Agents Chemother. 2006;50(2):774–7. CrossRef Hamelin MÈ, Prince GA, Boivin G. Effect of ribavirin and glucocorticoid treatment in a mouse model of human metapneumovirus infection. Antimicrob Agents Chemother. 2006;50(2):774–7. CrossRef
10.
Zurück zum Zitat Wyde PR, Chetty SN, Jewell AM, Boivin G, Piedra PA. Comparison of the inhibition of human metapneumovirus and respiratory syncytial virus by ribavirin and immune serum globulin in vitro. Antiviral Res. 2003;60(1):51–9. CrossRef Wyde PR, Chetty SN, Jewell AM, Boivin G, Piedra PA. Comparison of the inhibition of human metapneumovirus and respiratory syncytial virus by ribavirin and immune serum globulin in vitro. Antiviral Res. 2003;60(1):51–9. CrossRef
Metadaten
Titel
Lethal human metavirus pneumonia in a patient with chronic lymphocytic leukemia
verfasst von
MD Holger Rumpold
Publikationsdatum
18.08.2021
Verlag
Springer Vienna
Erschienen in
memo - Magazine of European Medical Oncology / Ausgabe 3/2021
Print ISSN: 1865-5041
Elektronische ISSN: 1865-5076
DOI
https://doi.org/10.1007/s12254-021-00734-0