Skip to main content

Tipp

Weitere Artikel dieser Ausgabe durch Wischen aufrufen

Erschienen in: European Surgery 2/2016

01.04.2016 | Review

Laryngopharyngeal reflux: diagnosis, treatment and latest research

verfasst von: MBBS, FRACS G. L. Falk, BA S. J. Vivian

Erschienen in: European Surgery | Ausgabe 2/2016

Einloggen, um Zugang zu erhalten
share
TEILEN

Summary

Aim

A review of the recent changes in understanding of laryngopharyngeal and extra-oesophageal reflux symptoms.

Method

Literature search over 7 years (2008–2015) and relevant historical cited articles.

Results

Modern investigation more clearly shows a subgroup of patients with intermittent full column oesophago-gastric-reflux-causing symptoms. Multiple other sites in the lung, head and neck may also be implicated in the reflux disease process.

Conclusion

Understanding of extra-oesophageal reflux symptomology is evolving. New equipment and techniques suggest further areas of research, and as yet effective therapy remains elusive for some.
Anhänge
Nur mit Berechtigung zugänglich
Literatur
3.
Zurück zum Zitat Vaezi MF. Extraesophageal Reflux. San Diego: Plural Publishing; 2009. Vaezi MF. Extraesophageal Reflux. San Diego: Plural Publishing; 2009.
5.
Zurück zum Zitat Gastroenterological Society of Australia. Gastro-oesophageal reflux disease in adults. 5. Edn. Mulgrave: Digestive Health Foundation; 2011. Gastroenterological Society of Australia. Gastro-oesophageal reflux disease in adults. 5. Edn. Mulgrave: Digestive Health Foundation; 2011.
6.
Zurück zum Zitat Mittal RK, Holloway RH, Penagini R, Blakshaw LA, Dent J. Transient lower esophageal relaxation. Gastroenterology. 1995;109:601–10. PubMedCrossRef Mittal RK, Holloway RH, Penagini R, Blakshaw LA, Dent J. Transient lower esophageal relaxation. Gastroenterology. 1995;109:601–10. PubMedCrossRef
15.
Zurück zum Zitat Behar J, Sheahan D. Histologic abnormalities in reflux esophagitis. Arch Pathol. 1975;99(7):387–91. PubMed Behar J, Sheahan D. Histologic abnormalities in reflux esophagitis. Arch Pathol. 1975;99(7):387–91. PubMed
16.
Zurück zum Zitat Lagergren J, Bergstrom R, Lindgren A, Nyren O. Symptomatic gastroesophageal reflux as a risk factor for esophageal adenocarcinoma. N Engl J Med. 1999;340(11):825–31. PubMedCrossRef Lagergren J, Bergstrom R, Lindgren A, Nyren O. Symptomatic gastroesophageal reflux as a risk factor for esophageal adenocarcinoma. N Engl J Med. 1999;340(11):825–31. PubMedCrossRef
20.
Zurück zum Zitat Pera M, Cameron AJ, Trastek VF, Carpenter HA, Zinsmeister AR. Increasing incidence of adenocarcinoma of the esophagus and esophagogastric junction. Gastroenterology. 1993;104(2):510–3. PubMed Pera M, Cameron AJ, Trastek VF, Carpenter HA, Zinsmeister AR. Increasing incidence of adenocarcinoma of the esophagus and esophagogastric junction. Gastroenterology. 1993;104(2):510–3. PubMed
21.
Zurück zum Zitat Di Pietro M, Fitzgerald RC. Screening and risk stratification for Barrett’s Esophagus. How to limit the clinical impact of the increasing incidence of Esophageal Adenocarcinoma. Gastroenterol Clin North Am. 2013;42(1):155–73. PubMedCrossRef Di Pietro M, Fitzgerald RC. Screening and risk stratification for Barrett’s Esophagus. How to limit the clinical impact of the increasing incidence of Esophageal Adenocarcinoma. Gastroenterol Clin North Am. 2013;42(1):155–73. PubMedCrossRef
22.
Zurück zum Zitat Haidry RJ, Dunn JM, Butt MA, Burnell M, Gupta A, Green S, et al. Radiofrequency Ablation (Rfa) And Endoscopic Mucosal Resection For Dysplastic Barrett’s Esophagus And Early Esophageal Adenocarcinoma: Outcomes Of Uk National Halo Rfa Registry. Gastroenterology. AGA Institute American Gastroenterological Association; 2013;(April):3447. http://​www.​ncbi.​nlm.​nih.​gov/​pubmed/​23542069. Accessed 2013 Apr 4 Haidry RJ, Dunn JM, Butt MA, Burnell M, Gupta A, Green S, et al. Radiofrequency Ablation (Rfa) And Endoscopic Mucosal Resection For Dysplastic Barrett’s Esophagus And Early Esophageal Adenocarcinoma: Outcomes Of Uk National Halo Rfa Registry. Gastroenterology. AGA Institute American Gastroenterological Association; 2013;(April):3447. http://​www.​ncbi.​nlm.​nih.​gov/​pubmed/​23542069. Accessed 2013 Apr 4
29.
Zurück zum Zitat Mainie I, Tutuian R, Shay S, Vela M, Zhang X, Sifrim D, et al. Acid and non-acid reflux in patients with persistent symptoms despite acid suppressive therapy: a multicentre study using combined ambulatory impedance-pH monitoring. Gut. 2006;55(10):1398–402. PubMedPubMedCentralCrossRef Mainie I, Tutuian R, Shay S, Vela M, Zhang X, Sifrim D, et al. Acid and non-acid reflux in patients with persistent symptoms despite acid suppressive therapy: a multicentre study using combined ambulatory impedance-pH monitoring. Gut. 2006;55(10):1398–402. PubMedPubMedCentralCrossRef
30.
Zurück zum Zitat Gyawali CP. High resolution manometry: the ray clouse legacy. Neurogastroenterol Motil. 2012;24(SUPPL 1):2–4. PubMedCrossRef Gyawali CP. High resolution manometry: the ray clouse legacy. Neurogastroenterol Motil. 2012;24(SUPPL 1):2–4. PubMedCrossRef
32.
Zurück zum Zitat Lundell LR, Dent J, Bennett JR, Blum a L, Armstrong D, Galmiche JP, et al. Endoscopic assessment of oesophagitis: clinical and functional correlates and further validation of the Los Angeles classification. Gut. 1999;45(2):172–80. PubMedPubMedCentralCrossRef Lundell LR, Dent J, Bennett JR, Blum a L, Armstrong D, Galmiche JP, et al. Endoscopic assessment of oesophagitis: clinical and functional correlates and further validation of the Los Angeles classification. Gut. 1999;45(2):172–80. PubMedPubMedCentralCrossRef
38.
Zurück zum Zitat SAGES. Guidelines for Surgical Treatment of Gastroesophageal Reflux Disease (GERD) Limitations of the Available Literature. 2001. p. 1–22. SAGES. Guidelines for Surgical Treatment of Gastroesophageal Reflux Disease (GERD) Limitations of the Available Literature. 2001. p. 1–22.
46.
Zurück zum Zitat Moazzez R, Bartlett D, Anggiansah A. Dental erosion, gastro-oesophageal reflux disease and saliva: how are they related? J Dent. 2004;32(6):489–94. PubMedCrossRef Moazzez R, Bartlett D, Anggiansah A. Dental erosion, gastro-oesophageal reflux disease and saliva: how are they related? J Dent. 2004;32(6):489–94. PubMedCrossRef
47.
Zurück zum Zitat Järvinen V, Meurman JH, Hyvärinen H, Rytömaa I, Murtomaa H. Dental erosion and upper gastrointestinal disorders. Oral Surgery. Oral Med Oral Pathol. 1988;65(3):298–303. CrossRef Järvinen V, Meurman JH, Hyvärinen H, Rytömaa I, Murtomaa H. Dental erosion and upper gastrointestinal disorders. Oral Surgery. Oral Med Oral Pathol. 1988;65(3):298–303. CrossRef
55.
Zurück zum Zitat Irwin RS. Chronic Cough Due to Gastroesophageal Reflux Disease: ACCP Evidence-Based Clinical Practice Guidelines. Chest. 2006;129(1_suppl):80S–94S. PubMedCrossRef Irwin RS. Chronic Cough Due to Gastroesophageal Reflux Disease: ACCP Evidence-Based Clinical Practice Guidelines. Chest. 2006;129(1_suppl):80S–94S. PubMedCrossRef
60.
Zurück zum Zitat Ekström T, Johansson KE. Effects of anti-reflux surgery on chronic cough and asthma in patients with gastro-oesophageal reflux disease. Respir Med. 2000;94(12):1166–70. PubMedCrossRef Ekström T, Johansson KE. Effects of anti-reflux surgery on chronic cough and asthma in patients with gastro-oesophageal reflux disease. Respir Med. 2000;94(12):1166–70. PubMedCrossRef
66.
Zurück zum Zitat Ludemann JP, Manoukian J, Shaw K, Bernard C, Davis M, Al-Jubab A. Effects of simulated gastroesophageal reflux on the untraumatized rabbit larynx. J Otolaryngol. 1998;27(3):127–31. PubMed Ludemann JP, Manoukian J, Shaw K, Bernard C, Davis M, Al-Jubab A. Effects of simulated gastroesophageal reflux on the untraumatized rabbit larynx. J Otolaryngol. 1998;27(3):127–31. PubMed
67.
Zurück zum Zitat Johnston N, Dettmar PW, Bishwokarma B, Lively MO, Koufman JA. Activity/stability of human pepsin: implications for reflux attributed laryngeal disease. Laryngoscope. 2007;117:1036–9. PubMedCrossRef Johnston N, Dettmar PW, Bishwokarma B, Lively MO, Koufman JA. Activity/stability of human pepsin: implications for reflux attributed laryngeal disease. Laryngoscope. 2007;117:1036–9. PubMedCrossRef
70.
Zurück zum Zitat Fornari F, Blondeau K, Durand L, Rey E, Diaz-Rubio M, De Meyer A, et al. Relevance of mild ineffective oesophageal motility (IOM) and potential pharmacological reversibility of severe IOM in patients with gastro-oesophageal reflux disease. Aliment Pharmacol Ther. 2007;26(10):1345–54. PubMedCrossRef Fornari F, Blondeau K, Durand L, Rey E, Diaz-Rubio M, De Meyer A, et al. Relevance of mild ineffective oesophageal motility (IOM) and potential pharmacological reversibility of severe IOM in patients with gastro-oesophageal reflux disease. Aliment Pharmacol Ther. 2007;26(10):1345–54. PubMedCrossRef
71.
Zurück zum Zitat Simrén M, Silny J, Holloway R, Tack J, Janssens J, Sifrim D. Relevance of ineffective oesophageal motility during oesophageal acid clearance. Intergovernmental panel on climate change. editor. Gut. Cambridge: Cambridge University Press; 2003;52(6):pp. 784–90. Simrén M, Silny J, Holloway R, Tack J, Janssens J, Sifrim D. Relevance of ineffective oesophageal motility during oesophageal acid clearance. Intergovernmental panel on climate change. editor. Gut. Cambridge: Cambridge University Press; 2003;52(6):pp. 784–90.
72.
Zurück zum Zitat Chen CL, Szczesniak MM, Cook IJ. Identification of impaired oesophageal bolus transit and clearance by secondary peristalsis in patients with non-obstructive dysphagia. Neurogastroenterol Motil. 2008;20(9):980–8. PubMedCrossRef Chen CL, Szczesniak MM, Cook IJ. Identification of impaired oesophageal bolus transit and clearance by secondary peristalsis in patients with non-obstructive dysphagia. Neurogastroenterol Motil. 2008;20(9):980–8. PubMedCrossRef
76.
Zurück zum Zitat Falk GL, Beattie J, Burton L, O’Donnell H, Falk MG, Van der Wall H, et al. Laryngopharyngeal reflux disease: correlation of reflux scintigraphy and 24 h impedance pH in a cohort of refractory symptomatic patients. Unpubl Work. 2015. Falk GL, Beattie J, Burton L, O’Donnell H, Falk MG, Van der Wall H, et al. Laryngopharyngeal reflux disease: correlation of reflux scintigraphy and 24 h impedance pH in a cohort of refractory symptomatic patients. Unpubl Work. 2015.
81.
Zurück zum Zitat Morice AH, Fontana GA, Sovijarvi ARA, Pistolesi M, Chung KF, Widdicombe J, et al. The diagnosis and management of chronic cough. Eur Respir J. 2004. p. 481–92. Morice AH, Fontana GA, Sovijarvi ARA, Pistolesi M, Chung KF, Widdicombe J, et al. The diagnosis and management of chronic cough. Eur Respir J. 2004. p. 481–92.
82.
Zurück zum Zitat Irwin R, French C, Curley F, Zawacki J, Bennett F. Chronic cough due to gastroesophageal reflux. Clinical, diagnostic, and pathogenetic aspects. Chest. 1993;104(5):1511–7. PubMedCrossRef Irwin R, French C, Curley F, Zawacki J, Bennett F. Chronic cough due to gastroesophageal reflux. Clinical, diagnostic, and pathogenetic aspects. Chest. 1993;104(5):1511–7. PubMedCrossRef
83.
85.
Zurück zum Zitat Ziora D, Jarosz W, Dzielicki J, Ciekalski J, Krzywiecki A, Dworniczak S, et al. Citric acid cough threshold in patients with gastroesophageal reflux disease rises after laparoscopic fundoplication. Chest. 2005;2458–64. Ziora D, Jarosz W, Dzielicki J, Ciekalski J, Krzywiecki A, Dworniczak S, et al. Citric acid cough threshold in patients with gastroesophageal reflux disease rises after laparoscopic fundoplication. Chest. 2005;2458–64.
89.
Zurück zum Zitat Belafsky PC, Postma GN, Koufman JA. Validity and reliability of the reflux symptom index (RSI). J Voice. 2002;16(2):274–7. PubMedCrossRef Belafsky PC, Postma GN, Koufman JA. Validity and reliability of the reflux symptom index (RSI). J Voice. 2002;16(2):274–7. PubMedCrossRef
92.
Zurück zum Zitat Branski RC, Bhattacharyya N, Shapiro J. The reliability of the assessment of endoscopic laryngeal findings associated with laryngopharyngeal reflux disease. Laryngoscope. 2002;112(6):1019–24. PubMedCrossRef Branski RC, Bhattacharyya N, Shapiro J. The reliability of the assessment of endoscopic laryngeal findings associated with laryngopharyngeal reflux disease. Laryngoscope. 2002;112(6):1019–24. PubMedCrossRef
97.
Zurück zum Zitat de Bortoli N, Nacci A, Savarino E, Martinucci I, Bellini M, Fattori B, et al. How many cases of laryngopharyngeal reflux suspected by laryngoscopy are gastroesophageal reflux disease-related? World J Gastroenterol. 2012;18(32):4363–70. PubMedPubMedCentralCrossRef de Bortoli N, Nacci A, Savarino E, Martinucci I, Bellini M, Fattori B, et al. How many cases of laryngopharyngeal reflux suspected by laryngoscopy are gastroesophageal reflux disease-related? World J Gastroenterol. 2012;18(32):4363–70. PubMedPubMedCentralCrossRef
98.
Zurück zum Zitat Vavricka SR, Storck CA, Wildi SM, Tutuian R, Wiegand N, Rousson V, et al. Limited diagnostic value of laryngopharyngeal lesions in patients with gastroesophageal reflux during routine upper gastrointestinal endoscopy. Am J Gastroenterol. 2007;102(4):716–22. PubMedCrossRef Vavricka SR, Storck CA, Wildi SM, Tutuian R, Wiegand N, Rousson V, et al. Limited diagnostic value of laryngopharyngeal lesions in patients with gastroesophageal reflux during routine upper gastrointestinal endoscopy. Am J Gastroenterol. 2007;102(4):716–22. PubMedCrossRef
99.
Zurück zum Zitat Belafsky PC, Postma GN, Koufman JA. The validity and reliability of the reflux finding score (RFS). Laryngoscope. 2001;111(8):1313–7. PubMedCrossRef Belafsky PC, Postma GN, Koufman JA. The validity and reliability of the reflux finding score (RFS). Laryngoscope. 2001;111(8):1313–7. PubMedCrossRef
101.
Zurück zum Zitat Vaezi MF, Hicks DM, Abelson TI, Richter JE. Laryngeal signs and symptoms and gastroesophageal reflux disease (GERD): a critical assessment of cause and effect association. Clin Gastroenterol Hepatol. 2003;1(5):333–44. PubMedCrossRef Vaezi MF, Hicks DM, Abelson TI, Richter JE. Laryngeal signs and symptoms and gastroesophageal reflux disease (GERD): a critical assessment of cause and effect association. Clin Gastroenterol Hepatol. 2003;1(5):333–44. PubMedCrossRef
102.
Zurück zum Zitat Koufman JA. The Otolaryngologic Manifestations of Gastroesophageal Reflux Disease (GERD): a clinical investigation of 225 patients using ambulatory 24-hour pH monitoring and an experimental investigation of the role of acid and pepsin in the development of laryngeal. Laryngoscope. 1991;101:1–77. PubMedCrossRef Koufman JA. The Otolaryngologic Manifestations of Gastroesophageal Reflux Disease (GERD): a clinical investigation of 225 patients using ambulatory 24-hour pH monitoring and an experimental investigation of the role of acid and pepsin in the development of laryngeal. Laryngoscope. 1991;101:1–77. PubMedCrossRef
104.
Zurück zum Zitat Zerbib F, Stoll D. Management of laryngopharyngeal reflux: an unmet medical need. Neurogastroenterol Motil. 2010;22(2):109–12. PubMedCrossRef Zerbib F, Stoll D. Management of laryngopharyngeal reflux: an unmet medical need. Neurogastroenterol Motil. 2010;22(2):109–12. PubMedCrossRef
110.
Zurück zum Zitat Karkos PD, Wilson JA. Empiric treatment of laryngopharyngeal reflux with proton pump inhibitors: a systematic review. Laryngoscope. 2006;116:144–8. PubMedCrossRef Karkos PD, Wilson JA. Empiric treatment of laryngopharyngeal reflux with proton pump inhibitors: a systematic review. Laryngoscope. 2006;116:144–8. PubMedCrossRef
111.
Zurück zum Zitat Qadeer MA, Phillips CO, Lopez AR, Steward DL, Noordzij JP, Wo JM, et al. Proton pump inhibitor therapy for suspected GERD-related chronic laryngitis: a meta-analysis of randomized controlled trials. Am J Gastroenterol. 2006;101(11):2646–54. PubMedCrossRef Qadeer MA, Phillips CO, Lopez AR, Steward DL, Noordzij JP, Wo JM, et al. Proton pump inhibitor therapy for suspected GERD-related chronic laryngitis: a meta-analysis of randomized controlled trials. Am J Gastroenterol. 2006;101(11):2646–54. PubMedCrossRef
117.
Zurück zum Zitat Decalmer S, Stovold R, Houghton LA, Pearson J, Ward C, Kelsall A, et al. Chronic cough: relationship between microaspiration, gastroesophageal reflux, and cough frequency. Chest. 2012;142(4):958–64. PubMedCrossRef Decalmer S, Stovold R, Houghton LA, Pearson J, Ward C, Kelsall A, et al. Chronic cough: relationship between microaspiration, gastroesophageal reflux, and cough frequency. Chest. 2012;142(4):958–64. PubMedCrossRef
122.
Zurück zum Zitat Samuels T, Johnston N. Pepsin as a marker of extraesophageal reflux. Ann Otol Rhinol Laryngo. 2010;119(3):203–8. Samuels T, Johnston N. Pepsin as a marker of extraesophageal reflux. Ann Otol Rhinol Laryngo. 2010;119(3):203–8.
128.
Zurück zum Zitat Sasaki C, Marotta J, Hundal J, Chow J, Eisen R. Bile-induced laryngitis: is there a basis in evidence? Ann Otol Rhinol Laryngol. 2005;114:192–7. PubMedCrossRef Sasaki C, Marotta J, Hundal J, Chow J, Eisen R. Bile-induced laryngitis: is there a basis in evidence? Ann Otol Rhinol Laryngol. 2005;114:192–7. PubMedCrossRef
134.
Zurück zum Zitat Russell C. Functional evaluation of the esophagus. In: Hill L, editor. The Esophagus Medical and surgical management. Philadelphia: WB Saunders; 1988. p. 45. Russell C. Functional evaluation of the esophagus. In: Hill L, editor. The Esophagus Medical and surgical management. Philadelphia: WB Saunders; 1988. p. 45.
142.
Zurück zum Zitat Anderson JW, Jhaveri MA. Reductions in medications with substantial weight loss with behavioral intervention. Curr Clin Pharmacol. 2010;5(4):232–8. PubMedCrossRef Anderson JW, Jhaveri MA. Reductions in medications with substantial weight loss with behavioral intervention. Curr Clin Pharmacol. 2010;5(4):232–8. PubMedCrossRef
143.
Zurück zum Zitat Fraser-Moodie CA, Norton B, Gornall C, Magnago S, Weale a R, Holmes GK. Weight loss has an independent beneficial effect on symptoms of gastro-oesophageal reflux in patients who are overweight. Scand J Gastroenterol. 1999;34(4):337–40. PubMedCrossRef Fraser-Moodie CA, Norton B, Gornall C, Magnago S, Weale a R, Holmes GK. Weight loss has an independent beneficial effect on symptoms of gastro-oesophageal reflux in patients who are overweight. Scand J Gastroenterol. 1999;34(4):337–40. PubMedCrossRef
144.
Zurück zum Zitat Reimer C, Bytzer P. Management of laryngopharyngeal reflux with proton pump inhibitors. Ther Clin Risk Manag. 2008;4(1):225–33. PubMedPubMedCentral Reimer C, Bytzer P. Management of laryngopharyngeal reflux with proton pump inhibitors. Ther Clin Risk Manag. 2008;4(1):225–33. PubMedPubMedCentral
146.
Zurück zum Zitat Ours TM, Keith Fackler W, Richter JE, Vaezi MF. Nocturnal acid breakthrough: clinical significance and correlation with esophageal acid exposure. Am J Gastroenterol. 2003;98(3):545–50. PubMedCrossRef Ours TM, Keith Fackler W, Richter JE, Vaezi MF. Nocturnal acid breakthrough: clinical significance and correlation with esophageal acid exposure. Am J Gastroenterol. 2003;98(3):545–50. PubMedCrossRef
152.
Zurück zum Zitat Dicpinigaitis PV, Rauf K. Treatment of chronic, refractory cough with baclofen. Respiration. 1998;65(1):86–8. PubMedCrossRef Dicpinigaitis PV, Rauf K. Treatment of chronic, refractory cough with baclofen. Respiration. 1998;65(1):86–8. PubMedCrossRef
154.
Zurück zum Zitat Lidums I, Lehmann A, Checklin H, Dent JHR. Control of transient lower esophageal sphincter relaxations and reflux by the GABA(B) agonist baclofen in normal subjects. Gastroenterology. 2000;118(1):7–13. PubMedCrossRef Lidums I, Lehmann A, Checklin H, Dent JHR. Control of transient lower esophageal sphincter relaxations and reflux by the GABA(B) agonist baclofen in normal subjects. Gastroenterology. 2000;118(1):7–13. PubMedCrossRef
155.
Zurück zum Zitat Dicpinigaitis P, Dobkin J, Rauf K, Aldrich T. Inhibition of capsaicin- induced cough by the gamma-aminobutyric acid agonist baclofen. J Clin Pharmacol. 1998;38:364–7. PubMedCrossRef Dicpinigaitis P, Dobkin J, Rauf K, Aldrich T. Inhibition of capsaicin- induced cough by the gamma-aminobutyric acid agonist baclofen. J Clin Pharmacol. 1998;38:364–7. PubMedCrossRef
157.
Zurück zum Zitat Pavesi L, Subburaj S, Porter-Shaw K. Application and validation of a computerized cough acquisition system for objective monitoring of acute cough: a meta-analysis. Chest. 2001;120(4):1121–8. PubMedCrossRef Pavesi L, Subburaj S, Porter-Shaw K. Application and validation of a computerized cough acquisition system for objective monitoring of acute cough: a meta-analysis. Chest. 2001;120(4):1121–8. PubMedCrossRef
158.
Zurück zum Zitat Young E, Sumner H, Decalmer S, Houghton L, Woodcock A, Smith J. Does central up-regulation of the n-methyl-d-aspartate receptor contribute to cough reflex hypersensitivity? Am J Respir Crit Care Med. 2010;181(Meeting Abstracts):A5906. Young E, Sumner H, Decalmer S, Houghton L, Woodcock A, Smith J. Does central up-regulation of the n-methyl-d-aspartate receptor contribute to cough reflex hypersensitivity? Am J Respir Crit Care Med. 2010;181(Meeting Abstracts):A5906.
166.
Zurück zum Zitat Greason KL, Miller DL, Deschamps C, Allen MS, Nichols FC, Trastek VF, et al. Effects of antireflux procedures on respiratory symptoms. Ann Thorac Surg. 2002;73(2):381–5. PubMedCrossRef Greason KL, Miller DL, Deschamps C, Allen MS, Nichols FC, Trastek VF, et al. Effects of antireflux procedures on respiratory symptoms. Ann Thorac Surg. 2002;73(2):381–5. PubMedCrossRef
167.
Zurück zum Zitat Brouwer R, Kiroff GK. Improvement of respiratory symptoms following laparoscopic Nissen fundoplication. ANZ J Surg. 2003;73(4):189–93. PubMedCrossRef Brouwer R, Kiroff GK. Improvement of respiratory symptoms following laparoscopic Nissen fundoplication. ANZ J Surg. 2003;73(4):189–93. PubMedCrossRef
169.
Zurück zum Zitat Spivak H, Smith CD, Phichith A, Galloway K, Waring JP, Hunter JG. Asthma and gastroesophageal reflux: fundoplication decreases need for systemic corticosteroids. J Gastrointest Surg. 1999;3(5):477–82. PubMedCrossRef Spivak H, Smith CD, Phichith A, Galloway K, Waring JP, Hunter JG. Asthma and gastroesophageal reflux: fundoplication decreases need for systemic corticosteroids. J Gastrointest Surg. 1999;3(5):477–82. PubMedCrossRef
Metadaten
Titel
Laryngopharyngeal reflux: diagnosis, treatment and latest research
verfasst von
MBBS, FRACS G. L. Falk
BA S. J. Vivian
Publikationsdatum
01.04.2016
Verlag
Springer Vienna
Erschienen in
European Surgery / Ausgabe 2/2016
Print ISSN: 1682-8631
Elektronische ISSN: 1682-4016
DOI
https://doi.org/10.1007/s10353-016-0385-5

Weitere Artikel der Ausgabe 2/2016

European Surgery 2/2016 Zur Ausgabe