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Erschienen in: Wiener klinisches Magazin 1/2023

11.01.2023 | Hämatologie

Klonale Hämatopoese und solide Neoplasien

verfasst von: Dr. Christopher Maximilian Arends, Prof. Dr. Frederik Damm

Erschienen in: Wiener klinisches Magazin | Ausgabe 1/2023

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Zusammenfassung

Hintergrund

Klonale Hämatopoese (CH) ist ein im Alter häufig auftretender prämaligner Zustand des hämatopoetischen Systems, der mit einem erhöhten kardiovaskulären Risiko und einer erhöhten Gesamtsterblichkeit einhergeht.

Fragestellung

Prävalenz und klinische Implikationen der CH bei PatientInnen mit soliden Neoplasien.

Material und Methoden

Sichtung, Zusammenfassung und Diskussion der Literatur.

Ergebnisse

CH tritt bei etwa 20–30 % der PatientInnen mit soliden Neoplasien auf. CH-Mutationen können bei der molekulargenetischen Analyse von Tumormaterial oder zellfreier DNA aus Plasma als Tumormutationen missinterpretiert werden. CH und insbesondere Mutationen in Genen der DNA-Reparatur-Maschinerie sind unter Chemo‑, Strahlen- und Poly-(Adenosindiphosphat-Ribose)-Polymerase-Inhibitor-Therapie mit einem erhöhten Risiko therapieassoziierter myeloischer Neoplasien (t-MN) assoziiert.

Schlussfolgerung

CH ist ein häufiges Phänomen bei PatientInnen mit soliden Neoplasien und hat aufgrund des t‑MN-Risikos eine hohe klinische Relevanz. Weitere Studien sind notwendig, um die Rolle der CH in diesem Patientenkollektiv besser zu verstehen und um evidenzbasierte Handlungsempfehlungen ableiten zu können.
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Metadaten
Titel
Klonale Hämatopoese und solide Neoplasien
verfasst von
Dr. Christopher Maximilian Arends
Prof. Dr. Frederik Damm
Publikationsdatum
11.01.2023
Verlag
Springer Vienna
Erschienen in
Wiener klinisches Magazin / Ausgabe 1/2023
Print ISSN: 1869-1757
Elektronische ISSN: 1613-7817
DOI
https://doi.org/10.1007/s00740-022-00472-x

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