Skip to main content
Erschienen in: Wiener klinisches Magazin 5/2018

06.09.2018 | Pathologie

Klinische und pathologische Charakteristika intravaskulärer Lymphome

verfasst von: Lara Abraham, Prof. Dr. Hans H. Kreipe, Dr. Peter Raab, Prof. Dr. Kais Hussein

Erschienen in: Wiener klinisches Magazin | Ausgabe 5/2018

Einloggen, um Zugang zu erhalten

Zusammenfassung

Intravaskuläre B‑Zell-Lymphome (IVL) sind seltene Neoplasien, die in jedem Alter auftreten können (Durchschnittsalter ca. 62–63 Jahre). Etwa die Hälfte der Fälle ist mit dem Epstein-Barr-Virus assoziiert. Die häufigsten Manifestationen finden sich im Gehirn, in der Haut und im Knochenmark. Die Diagnostik wird dadurch erschwert, dass die klinische Präsentation und die Laborwerte unspezifisch sind und die FACS(fluorescence-activated cell sorting)- und Klonalitätsanalysen aus dem peripheren Blut sowie die radiologischen Befunde nicht diagnostisch sein können. Die sensitivste und spezifischste diagnostische Methode ist die histopathologische und immunhistochemische Evaluation einer Gewebebiopsie. Wegen der Seltenheit dieser Krankheit gibt es nur wenige Erkenntnisse zu Therapie und Prognose, wobei die Therapie sich weitgehend an aggressiven Nicht-IVL-Lymphomen orientiert. Die Prognose ist schlecht (medianes Überleben nach Diagnose etwa ein Jahr).
Literatur
1.
Zurück zum Zitat Au WY, Shek WH, Nicholls J, Tse KM, Todd D, Kwong YL (1997) T‑cell intravascular lymphomatosis (angiotropic large cell lymphoma): association with Epstein-Barr viral infection. Histopathology 31:563–567CrossRef Au WY, Shek WH, Nicholls J, Tse KM, Todd D, Kwong YL (1997) T‑cell intravascular lymphomatosis (angiotropic large cell lymphoma): association with Epstein-Barr viral infection. Histopathology 31:563–567CrossRef
3.
Zurück zum Zitat Bi Y, Huo Z, Liang Z, Meng Y, Jia C, Shi X, Song L, Luo Y, Ling Q, Liu T (2015) Intravascular NK-cell lymphoma: a case report and review of the literature. Diagn Pathol 10:84CrossRef Bi Y, Huo Z, Liang Z, Meng Y, Jia C, Shi X, Song L, Luo Y, Ling Q, Liu T (2015) Intravascular NK-cell lymphoma: a case report and review of the literature. Diagn Pathol 10:84CrossRef
5.
Zurück zum Zitat Calvalope C, Ebbo M, Trousse D, Khibri H, Franques J, Chetaille B, Coso D, Ouvrier MJ, Gastaud L, Guedj E, Schleinitz N (2015) FDG-PET/CT is a pivotal imaging modality to diagnose rare intravascular large B‑cell lymphoma: case report and review of literature. Hematol Oncol 33:99–109CrossRef Calvalope C, Ebbo M, Trousse D, Khibri H, Franques J, Chetaille B, Coso D, Ouvrier MJ, Gastaud L, Guedj E, Schleinitz N (2015) FDG-PET/CT is a pivotal imaging modality to diagnose rare intravascular large B‑cell lymphoma: case report and review of literature. Hematol Oncol 33:99–109CrossRef
6.
Zurück zum Zitat Cerroni L, Massone C, Kutzner H, Mentzel T, Umbert P, Kerl H (2008) Intravascular large T‑cell or NK-cell lymphoma: a rare variant of intravascular large cell lymphoma with frequent cytotoxic phenotype and association with Epstein-Barr virus infection. Am J Surg Pathol 32:891–898CrossRef Cerroni L, Massone C, Kutzner H, Mentzel T, Umbert P, Kerl H (2008) Intravascular large T‑cell or NK-cell lymphoma: a rare variant of intravascular large cell lymphoma with frequent cytotoxic phenotype and association with Epstein-Barr virus infection. Am J Surg Pathol 32:891–898CrossRef
7.
Zurück zum Zitat Crane GM, Ambinder RF, Shirley CM, Fishman EK, Kasamon YL, Taube JM, Borowitz MJ, Duffield AS (2014) HHV-8-positive and EBV-positive intravascular lymphoma: an unusual presentation of extracavitary primary effusion lymphoma. Am J Surg Pathol 38:426–432CrossRef Crane GM, Ambinder RF, Shirley CM, Fishman EK, Kasamon YL, Taube JM, Borowitz MJ, Duffield AS (2014) HHV-8-positive and EBV-positive intravascular lymphoma: an unusual presentation of extracavitary primary effusion lymphoma. Am J Surg Pathol 38:426–432CrossRef
8.
Zurück zum Zitat Ferreri AJ, Campo E, Ambrosetti A, Ilariucci F, Seymour JF, Willemze R, Arrigoni G, Rossi G, López-Guillermo A, Berti E, Eriksson M, Federico M, Cortelazzo S, Govi S, Frungillo N, Dell’Oro S, Lestani M, Asioli S, Pedrinis E, Ungari M, Motta T, Rossi R, Artusi T, Iuzzolino P, Zucca E, Cavalli F, Ponzoni M (2004) Anthracycline-based chemotherapy as primary treatment for intravascular lymphoma. Ann Oncol 15:1215–1221CrossRef Ferreri AJ, Campo E, Ambrosetti A, Ilariucci F, Seymour JF, Willemze R, Arrigoni G, Rossi G, López-Guillermo A, Berti E, Eriksson M, Federico M, Cortelazzo S, Govi S, Frungillo N, Dell’Oro S, Lestani M, Asioli S, Pedrinis E, Ungari M, Motta T, Rossi R, Artusi T, Iuzzolino P, Zucca E, Cavalli F, Ponzoni M (2004) Anthracycline-based chemotherapy as primary treatment for intravascular lymphoma. Ann Oncol 15:1215–1221CrossRef
9.
Zurück zum Zitat Ferreri AJ, Campo E, Seymour JF, Willemze R, Ilariucci F, Ambrosetti A, Zucca E, Rossi G, López-Guillermo A, Pavlovsky MA, Geerts ML, Candoni A, Lestani M, Asioli S, Milani M, Piris MA, Pileri S, Facchetti F, Cavalli F, Ponzoni M, International Extranodal Lymphoma Study Group (IELSG) (2004) Intravascular lymphoma: clinical presentation, natural history, management and prognostic factors in a series of 38 cases, with special emphasis on the ‘cutaneous variant’. Br J Haematol 127:173–183CrossRef Ferreri AJ, Campo E, Seymour JF, Willemze R, Ilariucci F, Ambrosetti A, Zucca E, Rossi G, López-Guillermo A, Pavlovsky MA, Geerts ML, Candoni A, Lestani M, Asioli S, Milani M, Piris MA, Pileri S, Facchetti F, Cavalli F, Ponzoni M, International Extranodal Lymphoma Study Group (IELSG) (2004) Intravascular lymphoma: clinical presentation, natural history, management and prognostic factors in a series of 38 cases, with special emphasis on the ‘cutaneous variant’. Br J Haematol 127:173–183CrossRef
10.
Zurück zum Zitat Ferry JA, Sohani AR, Longtine JA, Schwartz RA, Harris NL (2009) HHV8-positive, EBV-positive Hodgkin lymphoma-like large B‑cell lymphoma and HHV8-positive intravascular large B‑cell lymphoma. Mod Pathol 34:1608 Ferry JA, Sohani AR, Longtine JA, Schwartz RA, Harris NL (2009) HHV8-positive, EBV-positive Hodgkin lymphoma-like large B‑cell lymphoma and HHV8-positive intravascular large B‑cell lymphoma. Mod Pathol 34:1608
11.
Zurück zum Zitat Fonkem E, Dayawansa S, Stroberg E, Lok E, Bricker PC, Kirmani B, Wong ET, Huang JH (2016) Neurological presentations of intravascular lymphoma (IVL): meta-analysis of 654 patients. Bmc Neurol 16:9CrossRef Fonkem E, Dayawansa S, Stroberg E, Lok E, Bricker PC, Kirmani B, Wong ET, Huang JH (2016) Neurological presentations of intravascular lymphoma (IVL): meta-analysis of 654 patients. Bmc Neurol 16:9CrossRef
12.
Zurück zum Zitat Fonkem E, Lok E, Robinson D, Gautam S, Wong ET (2014) The natural history of intravascular lymphomatosis. Cancer Med 3:1010–1024CrossRef Fonkem E, Lok E, Robinson D, Gautam S, Wong ET (2014) The natural history of intravascular lymphomatosis. Cancer Med 3:1010–1024CrossRef
13.
Zurück zum Zitat Glass J, Hochberg FH, Miller DC (1993) Intravascular lymphomatosis. A systemic disease with neurologic manifestations. Cancer 71:3156–3164CrossRef Glass J, Hochberg FH, Miller DC (1993) Intravascular lymphomatosis. A systemic disease with neurologic manifestations. Cancer 71:3156–3164CrossRef
14.
Zurück zum Zitat Ha JM, Kim E, Lee WJ, Hwang JW, Yune S, Ko YH, Choi JY, Kim SJ, Kim WS (2014) Unusual manifestation of intravascular large B‑cell lymphoma: severe hypercalcemia with parathyroid hormone-related protein. Cancer Res Treat 46:307–311CrossRef Ha JM, Kim E, Lee WJ, Hwang JW, Yune S, Ko YH, Choi JY, Kim SJ, Kim WS (2014) Unusual manifestation of intravascular large B‑cell lymphoma: severe hypercalcemia with parathyroid hormone-related protein. Cancer Res Treat 46:307–311CrossRef
15.
Zurück zum Zitat Heinrich A, Vogelgesang S, Kirsch M, Khaw AV (2005) Intravascular lymphomatosis presenting as rapidly progressive dementia. Eur Neurol 54:55–58CrossRef Heinrich A, Vogelgesang S, Kirsch M, Khaw AV (2005) Intravascular lymphomatosis presenting as rapidly progressive dementia. Eur Neurol 54:55–58CrossRef
16.
Zurück zum Zitat Hsiao CH, Su IJ, Hsieh SW, Huang SF, Tsai TF, Chen MY, How SW (1999) Epstein-Barr virus-associated intravascular lymphomatosis within Kaposi’s sarcoma in an AIDS patient. Am J Surg Pathol 23:482–487CrossRef Hsiao CH, Su IJ, Hsieh SW, Huang SF, Tsai TF, Chen MY, How SW (1999) Epstein-Barr virus-associated intravascular lymphomatosis within Kaposi’s sarcoma in an AIDS patient. Am J Surg Pathol 23:482–487CrossRef
17.
Zurück zum Zitat Kambara R, Horii A, Osak Y, Inohara H (2015) A case of intravascular lymphoma mimicking acute sinusitis in which the outcome was unfortunate. Nippon Jibiinkoka Gakkai Kaiho 118:770–775CrossRef Kambara R, Horii A, Osak Y, Inohara H (2015) A case of intravascular lymphoma mimicking acute sinusitis in which the outcome was unfortunate. Nippon Jibiinkoka Gakkai Kaiho 118:770–775CrossRef
18.
Zurück zum Zitat Kato M, Ohshima K, Mizuno M, Kyogoku M, Hashikawa K, Tokura Y, Miyachi Y, Kabashima K (2009) Analysis of CXCL9 and CXCR3 expression in a case of intravascular large B‑cell lymphoma. J Am Acad Dermatol 61:888–891CrossRef Kato M, Ohshima K, Mizuno M, Kyogoku M, Hashikawa K, Tokura Y, Miyachi Y, Kabashima K (2009) Analysis of CXCL9 and CXCR3 expression in a case of intravascular large B‑cell lymphoma. J Am Acad Dermatol 61:888–891CrossRef
20.
Zurück zum Zitat Khalidi HS, Brynes RK, Browne P, Koo CH, Battifora H, Medeiros LJ (1998) Intravascular large B‑cell lymphoma: the CD5 antigen is expressed by a subset of cases. Mod Pathol 11:983–988PubMed Khalidi HS, Brynes RK, Browne P, Koo CH, Battifora H, Medeiros LJ (1998) Intravascular large B‑cell lymphoma: the CD5 antigen is expressed by a subset of cases. Mod Pathol 11:983–988PubMed
22.
Zurück zum Zitat Momota H, Narita Y, Miyakita Y, Shibui S (2012) Intravascular lymphoma of the central nervous system presenting as multiple cerebral infarctions. Nagoya J Med Sci 74:353–358PubMedPubMedCentral Momota H, Narita Y, Miyakita Y, Shibui S (2012) Intravascular lymphoma of the central nervous system presenting as multiple cerebral infarctions. Nagoya J Med Sci 74:353–358PubMedPubMedCentral
23.
Zurück zum Zitat Moreno MJ, Bosch R, Dieguez-Gonzalez R, Novelli S, Mozos A, Gallardo A, Pavón MÁ, Céspedes MV, Grañena A, Alcoceba M, Blanco O, Gonzalez-Diaz M, Sierra J, Mangues R, Casanova I (2015) CXCR4 expression enhances diffuse large B cell lymphoma dissemination and decreases patient survival. J Pathol 235:445–455CrossRef Moreno MJ, Bosch R, Dieguez-Gonzalez R, Novelli S, Mozos A, Gallardo A, Pavón MÁ, Céspedes MV, Grañena A, Alcoceba M, Blanco O, Gonzalez-Diaz M, Sierra J, Mangues R, Casanova I (2015) CXCR4 expression enhances diffuse large B cell lymphoma dissemination and decreases patient survival. J Pathol 235:445–455CrossRef
24.
Zurück zum Zitat Murase T, Nakamura S, Kawauchi K, Matsuzaki H, Sakai C, Inaba T, Nasu K, Tashiro K, Suchi T, Saito H (2000) An Asian variant of intravascular large B‑cell lymphoma: clinical, pathological and cytogenetic approaches to diffuse large B‑cell lymphoma associated with haemophagocytic syndrome. Br J Haematol 111:826–834PubMed Murase T, Nakamura S, Kawauchi K, Matsuzaki H, Sakai C, Inaba T, Nasu K, Tashiro K, Suchi T, Saito H (2000) An Asian variant of intravascular large B‑cell lymphoma: clinical, pathological and cytogenetic approaches to diffuse large B‑cell lymphoma associated with haemophagocytic syndrome. Br J Haematol 111:826–834PubMed
25.
Zurück zum Zitat Murase T, Yamaguchi M, Suzuki R, Okamoto M, Sato Y, Tamaru J, Kojima M, Miura I, Mori N, Yoshino T, Nakamura S (2007) Intravascular large B‑cell lymphoma (IVLBCL): a clinicopathologic study of 96 cases with special reference to the immunophenotypic heterogeneity of CD5. Blood 109:478–485CrossRef Murase T, Yamaguchi M, Suzuki R, Okamoto M, Sato Y, Tamaru J, Kojima M, Miura I, Mori N, Yoshino T, Nakamura S (2007) Intravascular large B‑cell lymphoma (IVLBCL): a clinicopathologic study of 96 cases with special reference to the immunophenotypic heterogeneity of CD5. Blood 109:478–485CrossRef
26.
Zurück zum Zitat Nakajima S, Ohshima K, Kyogoku M, Miyachi Y, Kabashima K (2010) A case of intravascular large B‑cell lymphoma with atypical clinical manifestations and analysis of CXCL12 and CXCR4 expression. Arch Dermatol 146:686–687CrossRef Nakajima S, Ohshima K, Kyogoku M, Miyachi Y, Kabashima K (2010) A case of intravascular large B‑cell lymphoma with atypical clinical manifestations and analysis of CXCL12 and CXCR4 expression. Arch Dermatol 146:686–687CrossRef
27.
Zurück zum Zitat Nakamura S, Ponzoni M, Campo E (2017) Intravascular large B‑cell lymphoma. In: Swerdlow SH, Campo E, Harris LN, Jaffe ES, Pileri SA, Stein H, Thiele J, Arber DA, Hasserjian RP, Le Beau MM, Orazi A, Siebert R (Hrsg) WHO classification of tumours of haematopoietic and lymphoid tissues. World Health Organization, Genf, S 317–318 Nakamura S, Ponzoni M, Campo E (2017) Intravascular large B‑cell lymphoma. In: Swerdlow SH, Campo E, Harris LN, Jaffe ES, Pileri SA, Stein H, Thiele J, Arber DA, Hasserjian RP, Le Beau MM, Orazi A, Siebert R (Hrsg) WHO classification of tumours of haematopoietic and lymphoid tissues. World Health Organization, Genf, S 317–318
28.
Zurück zum Zitat Özsan N, Sarsık B, Yılmaz AF, Şimşir A, Dönmez A (2014) Intravascular large B‑cell lymphoma diagnosed on prostate biopsy: a case report. Turk J Haematol 31:403–407CrossRef Özsan N, Sarsık B, Yılmaz AF, Şimşir A, Dönmez A (2014) Intravascular large B‑cell lymphoma diagnosed on prostate biopsy: a case report. Turk J Haematol 31:403–407CrossRef
29.
Zurück zum Zitat Patel SS, Aasen GA, Dolan MM, Linden MA, McKenna RW, Rudrapatna VK, Trottier BJ, Drawz SM (2014) Early diagnosis of intravascular large B‑cell lymphoma: clues from routine blood smear morphologic findings. Lab Med 45:248–252CrossRef Patel SS, Aasen GA, Dolan MM, Linden MA, McKenna RW, Rudrapatna VK, Trottier BJ, Drawz SM (2014) Early diagnosis of intravascular large B‑cell lymphoma: clues from routine blood smear morphologic findings. Lab Med 45:248–252CrossRef
30.
Zurück zum Zitat Pfleger L, Tappeiner J (1959) On the recognition of systematized endotheliomatosis of the cutaneous blood vessels (reticuloendotheliosis?). Hautarzt 10:359–363PubMed Pfleger L, Tappeiner J (1959) On the recognition of systematized endotheliomatosis of the cutaneous blood vessels (reticuloendotheliosis?). Hautarzt 10:359–363PubMed
31.
Zurück zum Zitat Ponzoni M, Ferreri AJ, Campo E, Facchetti F, Mazzucchelli L, Yoshino T, Murase T, Pileri SA, Doglioni C, Zucca E, Cavalli F, Nakamura S (2007) Definition, diagnosis, and management of intravascular large B‑cell lymphoma: proposals and perspectives from an international consensus meeting. J Clin Oncol 25:3168–3173CrossRef Ponzoni M, Ferreri AJ, Campo E, Facchetti F, Mazzucchelli L, Yoshino T, Murase T, Pileri SA, Doglioni C, Zucca E, Cavalli F, Nakamura S (2007) Definition, diagnosis, and management of intravascular large B‑cell lymphoma: proposals and perspectives from an international consensus meeting. J Clin Oncol 25:3168–3173CrossRef
32.
Zurück zum Zitat Ponzoni M, Ferreri AJ (2006) Intravascular lymphoma: a neoplasm of ‘homeless’ lymphocytes? Hematol Oncol 24:105–112CrossRef Ponzoni M, Ferreri AJ (2006) Intravascular lymphoma: a neoplasm of ‘homeless’ lymphocytes? Hematol Oncol 24:105–112CrossRef
33.
Zurück zum Zitat Ponzoni M, Arrigoni G, Gould VE, Del Curto B, Maggioni M, Scapinello A, Paolino S, Cassisa A, Patriarca C (2000) Lack of CD 29 (beta1 integrin) and CD 54 (ICAM-1) adhesion molecules in intravascular lymphomatosis. Hum Pathol 31:220–226CrossRef Ponzoni M, Arrigoni G, Gould VE, Del Curto B, Maggioni M, Scapinello A, Paolino S, Cassisa A, Patriarca C (2000) Lack of CD 29 (beta1 integrin) and CD 54 (ICAM-1) adhesion molecules in intravascular lymphomatosis. Hum Pathol 31:220–226CrossRef
34.
Zurück zum Zitat Sawahara H, Iwamuro M, Ito M, Nose S, Nishimura M, Okada H (2017) Intravascular lymphoma with a gastric submucosal tumor. Nihon Shokakibyo Gakkai Zasshi 114:1446–1453PubMed Sawahara H, Iwamuro M, Ito M, Nose S, Nishimura M, Okada H (2017) Intravascular lymphoma with a gastric submucosal tumor. Nihon Shokakibyo Gakkai Zasshi 114:1446–1453PubMed
35.
Zurück zum Zitat Sharma TL, Yeaney GA, Soltanzadeh P, Li Y, Cotta CV (2017) Intravascular T‑cell lymphoma: a rare, poorly characterized entity with cytotoxic phenotype. Neuropathology 37:365–370CrossRef Sharma TL, Yeaney GA, Soltanzadeh P, Li Y, Cotta CV (2017) Intravascular T‑cell lymphoma: a rare, poorly characterized entity with cytotoxic phenotype. Neuropathology 37:365–370CrossRef
36.
Zurück zum Zitat Sheibani K, Battifora H, Winberg CD, Burke JS, Ben-Ezra J, Ellinger GM, Quigley NJ, Fernandez BB, Morrow D, Rappaport H (1986) Further evidence that “malignant angioendotheliomatosis” is an angiotropic large-cell lymphoma. N Engl J Med 314:943–948CrossRef Sheibani K, Battifora H, Winberg CD, Burke JS, Ben-Ezra J, Ellinger GM, Quigley NJ, Fernandez BB, Morrow D, Rappaport H (1986) Further evidence that “malignant angioendotheliomatosis” is an angiotropic large-cell lymphoma. N Engl J Med 314:943–948CrossRef
37.
Zurück zum Zitat Shimada K, Matsue K, Yamamoto K, Murase T, Ichikawa N, Okamoto M, Niitsu N, Kosugi H, Tsukamoto N, Miwa H, Asaoku H, Kikuchi A, Matsumoto M, Saburi Y, Masaki Y, Yamaguchi M, Nakamura S, Naoe T, Kinoshita T (2008) Retrospective analysis of intravascular large B‑cell lymphoma treated with rituximab-containing chemotherapy as reported by the IVL study group in Japan. J Clin Oncol 26:3189–3195CrossRef Shimada K, Matsue K, Yamamoto K, Murase T, Ichikawa N, Okamoto M, Niitsu N, Kosugi H, Tsukamoto N, Miwa H, Asaoku H, Kikuchi A, Matsumoto M, Saburi Y, Masaki Y, Yamaguchi M, Nakamura S, Naoe T, Kinoshita T (2008) Retrospective analysis of intravascular large B‑cell lymphoma treated with rituximab-containing chemotherapy as reported by the IVL study group in Japan. J Clin Oncol 26:3189–3195CrossRef
38.
Zurück zum Zitat Shinkawa Y, Hatachi S, Yagita M (2016) Intravascular large B‑cell lymphoma with a high titer of proteinase-3-anti-neutrophil cytoplasmic antibody mimicking granulomatosis with polyangiitis. Mod Rheumatol 11:1–3CrossRef Shinkawa Y, Hatachi S, Yagita M (2016) Intravascular large B‑cell lymphoma with a high titer of proteinase-3-anti-neutrophil cytoplasmic antibody mimicking granulomatosis with polyangiitis. Mod Rheumatol 11:1–3CrossRef
39.
Zurück zum Zitat Shimokawa I, Higami Y, Sakai H, Moriuchi Y, Murase K, Ikeda T (1991) Intravascular malignant lymphomatosis: a case of T‑cell lymphoma probably associated with human T‑cell lymphotropic virus. Hum Pathol 22:200–202CrossRef Shimokawa I, Higami Y, Sakai H, Moriuchi Y, Murase K, Ikeda T (1991) Intravascular malignant lymphomatosis: a case of T‑cell lymphoma probably associated with human T‑cell lymphotropic virus. Hum Pathol 22:200–202CrossRef
40.
Zurück zum Zitat Souza CA, Quan K, Seely J, Kravcik S, Burns B (2009) Pulmonary intravascular lymphoma. J Thorac Imaging 24:231–233CrossRef Souza CA, Quan K, Seely J, Kravcik S, Burns B (2009) Pulmonary intravascular lymphoma. J Thorac Imaging 24:231–233CrossRef
41.
Zurück zum Zitat Stroup RM, Sheibani K, Moncada A, Purdy LJ, Battifora H (1990) Angiotropic (intravascular) large cell lymphoma. A clinicopathologic study of seven cases with unique clinical presentations. Cancer 66:1781–1788CrossRef Stroup RM, Sheibani K, Moncada A, Purdy LJ, Battifora H (1990) Angiotropic (intravascular) large cell lymphoma. A clinicopathologic study of seven cases with unique clinical presentations. Cancer 66:1781–1788CrossRef
42.
Zurück zum Zitat Teicher BA, Fricker SP (2010) CXCL12 (SDF-1)/CXCR4 pathway in cancer. Clin Cancer Res 16:2927–2931CrossRef Teicher BA, Fricker SP (2010) CXCL12 (SDF-1)/CXCR4 pathway in cancer. Clin Cancer Res 16:2927–2931CrossRef
43.
Zurück zum Zitat Wang J, Ding W, Gao L, Yao W, Chen M, Zhao S, Liu W, Zhang W (2017) High frequency of Bone marrow involvement in intravascular large B‑cell lymphoma. Int J Surg Pathol 25:118–126CrossRef Wang J, Ding W, Gao L, Yao W, Chen M, Zhao S, Liu W, Zhang W (2017) High frequency of Bone marrow involvement in intravascular large B‑cell lymphoma. Int J Surg Pathol 25:118–126CrossRef
44.
Zurück zum Zitat Williams RL, Meltzer CC, Smirniotopoulos JG, Fukui MB, Inman M (1998) Cerebral MR imaging in intravascular lymphomatosis. AJNR Am J Neuroradiol 19:427–431PubMed Williams RL, Meltzer CC, Smirniotopoulos JG, Fukui MB, Inman M (1998) Cerebral MR imaging in intravascular lymphomatosis. AJNR Am J Neuroradiol 19:427–431PubMed
45.
Zurück zum Zitat Wong S, Fulcher D (2004) Chemokine receptor expression in B‑cell lymphoproliferative disorders. Leuk Lymphoma 45:2491–2496CrossRef Wong S, Fulcher D (2004) Chemokine receptor expression in B‑cell lymphoproliferative disorders. Leuk Lymphoma 45:2491–2496CrossRef
46.
Zurück zum Zitat Yamamoto A, Kikuchi Y, Homma K, O’uchi T, Furui S (2012) Characteristics of intravascular large B‑cell lymphoma on cerebral MR imaging. AJNR Am J Neuroradiol 33:292–296CrossRef Yamamoto A, Kikuchi Y, Homma K, O’uchi T, Furui S (2012) Characteristics of intravascular large B‑cell lymphoma on cerebral MR imaging. AJNR Am J Neuroradiol 33:292–296CrossRef
47.
Zurück zum Zitat Yoshikawa S, Kobayashi H, Kanda S, Furihata K, Ueno M, Kaneki T, Kodaira H, Ichikawa N, Koyama S, Saito H (2002) An Asian variant of intravascular lymphoma diagnosed through splenectomy. Intern Med 41:1215–1216CrossRef Yoshikawa S, Kobayashi H, Kanda S, Furihata K, Ueno M, Kaneki T, Kodaira H, Ichikawa N, Koyama S, Saito H (2002) An Asian variant of intravascular lymphoma diagnosed through splenectomy. Intern Med 41:1215–1216CrossRef
Metadaten
Titel
Klinische und pathologische Charakteristika intravaskulärer Lymphome
verfasst von
Lara Abraham
Prof. Dr. Hans H. Kreipe
Dr. Peter Raab
Prof. Dr. Kais Hussein
Publikationsdatum
06.09.2018
Verlag
Springer Vienna
Erschienen in
Wiener klinisches Magazin / Ausgabe 5/2018
Print ISSN: 1869-1757
Elektronische ISSN: 1613-7817
DOI
https://doi.org/10.1007/s00740-018-0245-y

Weitere Artikel der Ausgabe 5/2018

Wiener klinisches Magazin 5/2018 Zur Ausgabe

Anästhesie & Intensivmedizin

Iatrogene Anämie: Zu viel abgezapft?

Panorama

Panorama