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01.11.2016 | original article

Killer-cell immunoglobulin-like receptor and human leukocyte antigen-C genes in common variable immunodeficiency

verfasst von: Dr. Ozgur Kartal, MD, Prof. Ugur Musabak, Sait Yesillik, MD, Rahsan I. Sagkan, Aysel Pekel, Fevzi Demirel, MD, Abdullah Baysan, MD, Ali Selçuk, MD, Assoc. Prof. Mustafa Güleç, Prof. Osman Şener

Erschienen in: Wiener klinische Wochenschrift | Ausgabe 21-22/2016

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Summary

Background

We aimed herein to investigate the killer-cell immunoglobulin-like receptor (KIR) genes and human leukocyte antigen (HLA)-C alleles in patients with common variable immunodeficiency (CVID), and to reveal their differences from those in healthy population.

Methods

In all, 18 patients who have been diagnosed with CVID and 15 living donors of kidney transplant recipients were enrolled in the study. Polymerase chain reaction-sequence-specific primer (PCR-SSP) typing method was used in molecular genetic analysis. The frequencies of the genes in the study groups were statistically compared with each other using chi-square or Fisher exact tests, whichever were appropriate.

Results

Although there was no significant difference between both study groups with respect to distribution of KIR and HLA-C2 group genes, HLA-Cw7 allele frequency in patients with CVID was significantly lower than that in healthy population (P = 0.008).

Conclusion

This present study results support that HLA-Cw7 allele, an inhibitor of KIR ligand, may play a role in the pathogenesis of CVID.

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Titel: Killer-cell immunoglobulin-like receptor and human leukocyte antigen-C genes in common variable immunodeficiency
verfasst von: Dr. Ozgur Kartal, MD
Prof. Ugur Musabak
Sait Yesillik, MD
Rahsan I. Sagkan
Aysel Pekel
Fevzi Demirel, MD
Abdullah Baysan, MD
Ali Selçuk, MD
Assoc. Prof. Mustafa Güleç
Prof. Osman Şener
Publikationsdatum: 01.11.2016
Verlag: Springer Vienna
Erschienen in: Wiener klinische Wochenschrift / Ausgabe 21-22/2016
Print ISSN: 0043-5325
Elektronische ISSN: 1613-7671
DOI: https://doi.org/10.1007/s00508-015-0769-8

Springer Medizin Österreich

Summary

Background

Methods

Results

Conclusion

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