01.11.2016 | original article | Ausgabe 21-22/2016
Killer-cell immunoglobulin-like receptor and human leukocyte antigen-C genes in common variable immunodeficiency
- Zeitschrift:
- Wiener klinische Wochenschrift > Ausgabe 21-22/2016
Wichtige Hinweise
An erratum to this article is available at http://dx.doi.org/10.1007/s00508-015-0894-4.
Summary
Background
We aimed herein to investigate the killer-cell immunoglobulin-like receptor (KIR) genes and human leukocyte antigen (HLA)-C alleles in patients with common variable immunodeficiency (CVID), and to reveal their differences from those in healthy population.
Methods
In all, 18 patients who have been diagnosed with CVID and 15 living donors of kidney transplant recipients were enrolled in the study. Polymerase chain reaction-sequence-specific primer (PCR-SSP) typing method was used in molecular genetic analysis. The frequencies of the genes in the study groups were statistically compared with each other using chi-square or Fisher exact tests, whichever were appropriate.
Results
Although there was no significant difference between both study groups with respect to distribution of KIR and HLA-C2 group genes, HLA-Cw7 allele frequency in patients with CVID was significantly lower than that in healthy population (P = 0.008).
Conclusion
This present study results support that HLA-Cw7 allele, an inhibitor of KIR ligand, may play a role in the pathogenesis of CVID.