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Killer-cell immunoglobulin-like receptor and human leukocyte antigen-C genes in common variable immunodeficiency

Zeitschrift:: Wiener klinische Wochenschrift > Ausgabe 21-22/2016

Autoren:: MD Dr. Ozgur Kartal, Prof. Ugur Musabak, MD Sait Yesillik, Rahsan I. Sagkan, Aysel Pekel, MD Fevzi Demirel, MD Abdullah Baysan, MD Ali Selçuk, Assoc. Prof. Mustafa Güleç, Prof. Osman Şener

Wichtige Hinweise

An erratum to this article is available at http://dx.doi.org/10.1007/s00508-015-0894-4.

Summary

Background

We aimed herein to investigate the killer-cell immunoglobulin-like receptor (KIR) genes and human leukocyte antigen (HLA)-C alleles in patients with common variable immunodeficiency (CVID), and to reveal their differences from those in healthy population.

Methods

In all, 18 patients who have been diagnosed with CVID and 15 living donors of kidney transplant recipients were enrolled in the study. Polymerase chain reaction-sequence-specific primer (PCR-SSP) typing method was used in molecular genetic analysis. The frequencies of the genes in the study groups were statistically compared with each other using chi-square or Fisher exact tests, whichever were appropriate.

Results

Although there was no significant difference between both study groups with respect to distribution of KIR and HLA-C2 group genes, HLA-Cw7 allele frequency in patients with CVID was significantly lower than that in healthy population (P = 0.008).

Conclusion

This present study results support that HLA-Cw7 allele, an inhibitor of KIR ligand, may play a role in the pathogenesis of CVID.

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Titel: Killer-cell immunoglobulin-like receptor and human leukocyte antigen-C genes in common variable immunodeficiency
Autoren:: MD Dr. Ozgur Kartal
Prof. Ugur Musabak
MD Sait Yesillik
Rahsan I. Sagkan
Aysel Pekel
MD Fevzi Demirel
MD Abdullah Baysan
MD Ali Selçuk
Assoc. Prof. Mustafa Güleç
Prof. Osman Şener
Publikationsdatum: 01.11.2016
DOI: https://doi.org/10.1007/s00508-015-0769-8
Verlag: Springer Vienna
Zeitschrift: Wiener klinische Wochenschrift The Central European Journal of Medicine
Ausgabe 21-22/2016
Print ISSN: 0043-5325
Elektronische ISSN: 1613-7671

Springer Medizin Österreich

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Summary

Background

Methods

Results

Conclusion

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