Wiener klinische Wochenschrift OnlineFirst articles

22.11.2023 | original article

Construction of a prognostic risk model for Stomach adenocarcinoma based on endoplasmic reticulum stress genes

Characterized by the fast progression and high invasiveness [ 1 ], stomach adenocarcinoma (STAD), the most common gastric cancer (GC) subtype, stands at fifth and third in incidence rate and mortality rate among other cancers, respectively [ 2 ].

verfasst von:: Xi Li, Yuehua Lei

10.11.2023 | original article

Does cannabis elevate cancer risk?

Evidence from Mendelian randomization

Cannabis is one of the commonly used psychotropic substances and is often used for medical and recreational purposes. Cannabis use and dependence is thought to be associated with an increased risk of mental disorders, reduced cognitive function …

verfasst von:: Dong Niu, Chenchen Li, Haoran Qu, Yuling Zheng

Open Access 10.11.2023 | original article

Outcome of COVID-19 patients treated with VV-ECMO in Tyrol during the pandemic

During the years 2020–2022 intensive care units (ICU) were faced with the challenge of treating critically ill patients infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). These patients were mostly admitted to ICUs due to …

verfasst von:: Andreas Peer, Fabian Perschinka, Georg Lehner, Timo Mayerhöfer, Peter Mair, Juliane Kilo, Robert Breitkopf, Dietmar Fries, Prof. Michael Joannidis, M.D.

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30.10.2023 | original article

Predictors of static and dynamic balance control in kidney transplant recipients

Kidney transplantation, the most frequently performed organ transplantation worldwide, is the primary therapeutic option for end-stage renal disease [ 1 ]. Despite improved graft and patient survival based on the advancements in surgical procedures …

verfasst von:: Hatice Nihan Bozkurt, Meriç Yıldırım, Ali Çelik, Serkan Yıldız

24.10.2023 | original article

FOXP3 expression in esophageal squamous cell carcinoma

Implications for cetuximab sensitivity and therapeutic strategies

Esophageal cancer is known to be a highly lethal form of cancer, with a 5-year survival rate of less than 25% for patients diagnosed at advanced stages. Esophageal squamous cell carcinoma (ESCC), which is the predominant histological type …

verfasst von:: Shenghong Wu, Yu Wang, Zhijun Xiao, Jinfeng Zhang, Zhonghui He, Ming Ye

Open Access 12.10.2023 | original article

Efficacy of cx601 (darvadstrocel) for the treatment of perianal fistulizing Crohn’s disease—A prospective nationwide multicenter cohort study

Perianal fistulas are common and occur in up to 40% of Crohn’s disease (CD) patients [ 1 , 2 ]. In the first two decades after initial CD diagnosis, about 28% suffer from this complication [ 1 ], causing substantial morbidity and reduced the …

verfasst von:: Christopher Dawoud, Kerstin Melanie Widmann, Sascha Czipin, Michael Pramhas, Martina Scharitzer, Anton Stift, Felix Harpain, Assoc. Prof. PD Stefan Riss, FRCS

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10.10.2023 | original article

Clinical results of acetabular fracture treatment with hybrid fixation by anterior and posterior approach

A minimally invasive technique

Acetabular fractures with a prevalence of 3 in 10,000 people are among the most serious injuries treated by orthopedic surgeons [ 1 ]. They are often associated with many complications and long-term physical disability [ 2 – 4 ]. The incidence of …

verfasst von:: associated professor Mohammad Qoreishy, Abdoreza Sajedi, Morteza Gholipour, Mona Gorji, associated professor Arash Maleki

Open Access 29.09.2023 | original article

ELIMINATE: a PCR record-based macroelimination project for systematic recall of HCV-RNA-positive persons in Austria

Despite the declaration of global hepatitis C virus (HCV) elimination by 2030 as a WHO public health goal and the availability of directly acting antivirals (DAA) facilitating sustained virologic response (SVR) rates of > 95%, HCV remains a major …

verfasst von:: Caroline Schwarz, MD, David Bauer, MD, Livia Dorn, MD, MPH, Mathias Jachs, MD, Lukas Hartl, MD, David Chromy, MD, Assoc. Prof. Lukas Weseslindtner, MD, Nikolaus Pfisterer, MD, Barbara Hennlich, MD, Annika Stückler, MD, Robert Strassl, MD, Priv. Doz. Astrid Voill-Glaninger, MD, Prof. Wolfgang Hübl, MD, Univ. Doz. Martin Willheim, MD, Karin Köhrer, MSc, MBA, MD, Sonja Jansen-Skoupy, MD, Sabine Tomez, MD, Univ. Doz. Walter Krugluger, MD, Prof. Christian Madl, MD, Michael Schwarz, MD, Lorenz Balcar, MD, Georg Semmler, MD, Leonard Brinkmann, MD, Lukas Burghart, MD, Lukas Antonitsch, MD, Gerhard Weidinger, MD, Florian Riedl, MD, Hermann Laferl, MD, Vesselina Kurteva, MD, Marianna Traugott, MD, Julian Hind, MD, Univ. Doz. Christoph Wenisch, MD, Abdelrahman Aburaia, Prof. Christian Sebesta, MD, Priv. Doz. Daniela Schmid, MD, Sonja Rothweiler, PhD, Jelena Remetic, PhD, Prof. Michael Gschwantler, MD, Prof. Andreas Maieron, MD, Prof. Thomas Reiberger, MD

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Open Access 08.09.2023 | consensus report

Updated Austrian treatment algorithm for metastatic triple-negative breast cancer

Approximately 15% of newly diagnosed breast cancer patients have neither hormone receptors expression nor HER2 overexpression and/or HER2/neu gene amplification. This subtype of breast cancer is known as Triple Negative Breast Cancer (TNBC), and …

verfasst von:: Assoz. Prof. PD Dr. Rupert Bartsch, PD Dr. Gabriel Rinnerthaler, Univ. Prof. Dr. Edgar Petru, OA Dr. Daniel Egle, Univ. Prof. Dr. Michael Gnant, Assoz. Prof. PD Dr. Marija Balic, OA Dr. Thamer Sliwa, Univ. Prof. Dr. Christian Singer

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Open Access 31.08.2023 | original article

Open surgical treatment of unicameral bone cysts

A retrospective data analysis

Surgical management of symptomatic unicameral bone cysts (UBC) warrants an ongoing discussion. As high intraosseous pressure by venous obstruction and enzymatic lysis are mostly considered responsible for UBC pathogenesis, modern approaches aim …

verfasst von:: Kevin Döring, MD, Géraldine D. Sturz, MD, Gerhard Hobusch, MD, Stephan Puchner, MD, Reinhard Windhager, MD, Catharina Chiari, MD

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03.08.2023 | original article

Prospective use of molecular minimal residual disease for risk stratification in children and adolescents with acute lymphoblastic leukemia

Long-term results of the AIEOP-BFM ALL 2000 trial in Austria

Since 1979 Austrian children and adolescents with acute lymphoblastic leukemia (ALL) have been treated according to protocols of the Berlin-Frankfurt-Münster (BFM) study group. The Associazione Italiana di Ematologia e Oncologia Pediatrica and BFM …

verfasst von:: Leila Ronceray, Michael Dworzak, Karin Dieckmann, Georg Ebetsberger-Dachs, Evgenia Glogova, Oskar A. Haas, Neil Jones, Karin Nebral, Reinhard Moser, Thomas Lion, Bernhard Meister, Renate Panzer-Grümayer, Sabine Strehl, Christina Peters, Ulrike Pötschger, Christian Urban, Georg Mann, Prof. Andishe Attarbaschi, MD, the Austrian Berlin-Frankfurt-Münster (BFM) Study Group

04.07.2023 | original article

High-density lipoprotein (HDL) has an impact on myeloma outcome: Lower HDL associates with worse progression-free survival

Multiple myeloma (MM) is a malignant disease of the elderly. In the era of novel therapeutic approaches, these patients survive longer than in the past. To predict the disease’s outcome and manage the optimal treatment, International Staging …

verfasst von:: Işıl Erdoğan Özünal, MD, Emrah Kılıçaslan, Tayfun Elibol, Erman Öztürk

Open Access 28.06.2023 | original article

Clinical course of congestive hepatopathy pre/post heart transplantation

Congestive liver disease represents a type of liver pathology which is caused by impaired blood outflow from the liver [ 1 ]. This pathology is mostly caused by heart failure (HF) [ 2 ]. Chronic hepatic congestion is a term used to describe long …

verfasst von:: Lorenz Balcar, M.D., Georg Semmler, M.D., Bernhard Scheiner, M.D. Ph.D., Albert Friedrich Stättermayer, M.D., Stefan Ćosić, Philipp Schwabl, M.D. Ph.D., Niema Kazem, M.D. Ph.D., Mattias Mandorfer, M.D. Ph.D., Martin Hülsmann, M.D., Andreas Zuckermann, M.D., Thomas Reiberger, M.D.

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05.06.2023 | original article

Revisiting the Epworth sleepiness scale

Is excessive daytime sleepiness still a valid screening tool for obstructive sleep apnea in a population at risk?

Excessive daytime sleepiness (EDS), defined as sleepiness that occurs unintentionally during daily situations when an individual is expected to be awake and alert [ 1 ], is responsible for daytime working inefficiency and work-related and …

verfasst von:: Hrvoje Puretić, MD, Assist. Prof. Marijana Bosnar Puretić, MD, PhD, Assoc. Prof. Gordana Pavliša, MD, PhD, Prof. Marko Jakopović, MD, PhD

27.04.2023 | original article

No association of NAFLD-related polymorphisms in PNPLA3 and TM6SF2 with all-cause and cardiovascular mortality in an Austrian population study

Genotyping is increasingly performed to understand the individual risk for non-alcoholic fatty liver disease (NAFLD)[ 1 ]. Most prominently, the PNPLA3 rs738409 G -allele has shown clear associations with the presence and severity of (fatty) liver …

verfasst von:: Georg Semmler, Lorenz Balcar, Sarah Wernly, Leonora Datz, Marie Semmler, Lea Rosenstatter, Felix Stickel, Elmar Aigner, Bernhard Wernly, Christian Datz, M.D.

Open Access 09.03.2023 | original article

Statements of Austrian hospices and palliative care units after the implementation of the law on assisted suicide

A qualitative study of web-based publications

In Austria, assisted suicide (AS) is regulated by the recently adopted federal Assisted Dying Act (Sterbeverfügungsgesetz, StVfG) Federal Law Gazette (Bundesgesetzblatt) BGBl. I Nr. 242/2021, which allows terminally ill people access to medically …

verfasst von:: Anna Kitta, MD, M.Sc., Franziska Ecker, MD, Elisabeth Lucia Zeilinger, M.Sc., PhD, Lea Kum, MD, Feroniki Adamidis, MD, Eva Katharina Masel, MD, Ph.D., MSc

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