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Wiener klinische Wochenschrift OnlineFirst articles

03.08.2023 | original article

Prospective use of molecular minimal residual disease for risk stratification in children and adolescents with acute lymphoblastic leukemia

Long-term results of the AIEOP-BFM ALL 2000 trial in Austria

Since 1979 Austrian children and adolescents with acute lymphoblastic leukemia (ALL) have been treated according to protocols of the Berlin-Frankfurt-Münster (BFM) study group. The Associazione Italiana di Ematologia e Oncologia Pediatrica and BFM …

verfasst von:
Leila Ronceray, Michael Dworzak, Karin Dieckmann, Georg Ebetsberger-Dachs, Evgenia Glogova, Oskar A. Haas, Neil Jones, Karin Nebral, Reinhard Moser, Thomas Lion, Bernhard Meister, Renate Panzer-Grümayer, Sabine Strehl, Christina Peters, Ulrike Pötschger, Christian Urban, Georg Mann, Prof. Andishe Attarbaschi, MD, the Austrian Berlin-Frankfurt-Münster (BFM) Study Group

Open Access 02.08.2023 | original article

Effect of repeatedly applied cold water immersion on subclinical atherosclerosis, inflammation, fat accumulation and lipid profile parameters of volunteers

Significant acute cardiovascular, metabolic, and endocrine changes have been traced to short-lasting cold water immersion (CWI); however, the long-term impact of recurrent CWI on atherogenesis, lipid parameters, and fat distribution has not yet …

verfasst von:
Assoc. prof. Dr. Štefan Tóth, PhD, Dr. Marianna Barbierik Vachalcová, PhD, Mgr. Dávid Kaško, PhD, Martin Turek, RNDr. Zuzana Guľašová, PhD, RNDr. Zdenka Hertelyová, PhD

Open Access 31.07.2023 | original article

Evolocumab effectiveness in the real-world setting: Austrian data from the pan-European observational HEYMANS study

Cardiovascular disease (CVD) is the most frequent cause of death in Austria, claiming 31,403 lives in 2021 [ 1 ]. One of the main risk factors for CVD is high low-density lipoprotein cholesterol (LDL-C), which is associated with increased …

verfasst von:
Ao. Univ.-Prof. Dr. Christoph Ebenbichler, Heinz Drexel, Ursula Hanusch, Hermann Toplak, Nafeesa N. Dhalwani, Ian Bridges, Robert Hoelzl, Margit Hemetsberger, Kausik K. Ray

Open Access 05.07.2023 | original article

Seasonality of benign paroxysmal positional vertigo

A retrospective study from Central Europe

Benign paroxysmal positional vertigo (BPPV) is the most common cause of vertigo seen in balance clinics, with a lifetime prevalence of up to 2.4% [ 1 ]. Although BPPV can occur at any age, the peak age is around 60–70 years. Women are generally …

verfasst von:
Ap. Prof., PD Heidemarie Zach, MD, PHD, BSc, David Retter, MD, Michaela Schmoeger, MD, Assoc. Prof., PD Mag.rer.nat. Paulus Rommer, Assoc. Prof. Dr. Ulrike Willinger, Felix K. Schwarz, MD, Assoc. Prof. Gerald Wiest, MD

04.07.2023 | original article

High-density lipoprotein (HDL) has an impact on myeloma outcome: Lower HDL associates with worse progression-free survival

Multiple myeloma (MM) is a malignant disease of the elderly. In the era of novel therapeutic approaches, these patients survive longer than in the past. To predict the disease’s outcome and manage the optimal treatment, International Staging …

verfasst von:
Işıl Erdoğan Özünal, MD, Emrah Kılıçaslan, Tayfun Elibol, Erman Öztürk

30.06.2023 | case report

Neuronal intranuclear inclusion disease with cortical involvement in left hemisphere: a case report

Neuronal intranuclear inclusion disease (NIID) is a neurodegenerative condition characterized by the loss of neurons and the presence of eosinophilic nuclear inclusions in the central, peripheral, and autonomic nervous systems. The common clinical …

verfasst von:
Xiao-ju Wu, Yi-ying Jiang, Li-jie Chen, Guo-qiu Zhou, Dong-can Mo, Liu-yu Liu, Jian-li Li, Xiao-ling Li, Yu-lan Tang, Man Luo, M.D., Ph.D.

Open Access 30.06.2023 | historical article

Development of a highly purified tick-borne encephalitis vaccine

A personal historical account

Before the advent of a vaccine, infections with tick-borne encephalitis (TBE) virus in Austria led to the hospitalization of several hundred and, due to underreporting, possibly more than thousand patients with severe neurological disease every …

verfasst von:
Franz X. Heinz

Open Access 28.06.2023 | original article

Clinical course of congestive hepatopathy pre/post heart transplantation

Congestive liver disease represents a type of liver pathology which is caused by impaired blood outflow from the liver [ 1 ]. This pathology is mostly caused by heart failure (HF) [ 2 ]. Chronic hepatic congestion is a term used to describe long …

verfasst von:
Lorenz Balcar, M.D., Georg Semmler, M.D., Bernhard Scheiner, M.D. Ph.D., Albert Friedrich Stättermayer, M.D., Stefan Ćosić, Philipp Schwabl, M.D. Ph.D., Niema Kazem, M.D. Ph.D., Mattias Mandorfer, M.D. Ph.D., Martin Hülsmann, M.D., Andreas Zuckermann, M.D., Thomas Reiberger, M.D.

Open Access 23.06.2023 | review article

Ultrasound utilization for implantation of cardiac implantable electronic devices

Ultrasound (US) guidance for implantation of cardiac implantable electronic devices (CIED) is currently not routine practice. This article sought to review published data on the use of ultrasound in each of the major surgical steps involved in …

verfasst von:
Muhtashim Mian, MD, MSc, Habib Rehman Khan, MBBS, PhD

Open Access 07.06.2023 | short report

The positive effect of spermidine in older adults suffering from dementia after 1 year

Based on our promising results, according to which the oral intake of spermidine has already shown a positive effect on memory performance after 3 months [ 1 ], the nursing home group participating in the study decided to change the meals of all …

verfasst von:
Thomas Pekar, Aribert Wendzel, Reinhart Jarisch

Open Access 06.06.2023 | review article

The three pillars in treating antibody-mediated encephalitis

The rapid initiation of immunotherapy has a decisive impact on the course of the disease in patients with antibody-mediated encephalitis (AE). The importance of treating AE with antiseizure medication and antipsychotics is discussed …

verfasst von:
S. Macher, G. Bsteh, E. Pataraia, T. Berger, R. Höftberger, P. S. Rommer

06.06.2023 | original article

Sex differences in vision and hearing impairments across age and European regions

Findings from SHARE

Sensory impairments such as vision impairment and hearing impairment are common conditions among the middle-aged and older populations, and the prevalence of these conditions increases with age [ 1 – 3 ]. Vision and hearing impairments are some of …

verfasst von:
Rikke Syrak Hansen, MScPH, Lasse Lybecker Scheel-Hincke, MScPH, Bernard Jeune, PhD, Linda Juel Ahrenfeldt, PhD

06.06.2023 | original article

Psychometric properties of the Turkish version of the fear avoidance components scale in patients with chronic pain related to musculoskeletal disorders

In the recent past, pain was addressed and evaluated independently of nonphysical conditions, including past sensory experience, sensory dimension, genetic difference, and anxiety. Over time, there have been many developments in resolving pain …

verfasst von:
Kadir Turan, PT, MSc, Zübeyir Sarı, PT, PhD, Fatih Özden, PT, PhD

05.06.2023 | original article

Revisiting the Epworth sleepiness scale

Is excessive daytime sleepiness still a valid screening tool for obstructive sleep apnea in a population at risk?

Excessive daytime sleepiness (EDS), defined as sleepiness that occurs unintentionally during daily situations when an individual is expected to be awake and alert [ 1 ], is responsible for daytime working inefficiency and work-related and …

verfasst von:
Hrvoje Puretić, MD, Assist. Prof. Marijana Bosnar Puretić, MD, PhD, Assoc. Prof. Gordana Pavliša, MD, PhD, Prof. Marko Jakopović, MD, PhD

01.06.2023 | original article

Effect of a protein kinase B (Akt) inhibitor on the angiogenesis of HUVECs and corneal neovascularization

Abnormal new vessels can invade the corneal stroma from pre-existing pericorneal structures due to a disruption in the balance of angiogenic and antiangiogenic factors, subsequently leading to corneal neovascularization (CNV). These two types of …

verfasst von:
Dr. Xing Wang, M.D., Pro. Peng Wang, M.D.

Open Access 31.05.2023 | historical article

The history of circadian rhythm research in Austria

In view of the recent revival of interest in circadian biology and circadian epidemiology at the Medical University of Vienna, it seems appropriate to highlight the rich and pioneering history of circadian research in Austria. Among the …

verfasst von:
Eva S. Schernhammer, MD, DrPH, Gerhard Klösch, MPH, Isabella Ellinger, PhD, Dietmar Winkler, MD, Edda Winkler-Pjrek, MD, Galateja Jordakieva, MD, PhD, Kyriaki Papantoniou, MD, PhD, Susanne Strohmaier, DI, PhD, Bertrand Lell, MD, MPH, MSc, Franz Waldhauser, MD

31.05.2023 | original article

Downregulation of lncRNA LINC01465 predicts ovarian endometriosis and its prognosis

The well-known impact of ovarian endometriosis on female quality of life and the established role of lncRNA LINC01465 in ovarian cancer pathogenesis have been extensively documented; however, the relationship between LINC01465 and ovarian …

verfasst von:
Yuying Song, Rui Huang, Xiangmei Hu, Shanshan Wu, Sihe Chen, Guangshen Liu, Mingzhi Ou, Haichun Guo

27.04.2023 | original article

No association of NAFLD-related polymorphisms in PNPLA3 and TM6SF2 with all-cause and cardiovascular mortality in an Austrian population study

Genotyping is increasingly performed to understand the individual risk for non-alcoholic fatty liver disease (NAFLD)[ 1 ]. Most prominently, the PNPLA3 rs738409 G -allele has shown clear associations with the presence and severity of (fatty) liver …

verfasst von:
Georg Semmler, Lorenz Balcar, Sarah Wernly, Leonora Datz, Marie Semmler, Lea Rosenstatter, Felix Stickel, Elmar Aigner, Bernhard Wernly, Christian Datz, M.D.

Open Access 17.04.2023 | review article

Hypertensive response to exercise, hypertension and heart failure with preserved ejection fraction (HFpEF)—a continuum of disease?

The global prevalence of heart failure (HF) ranges between 1–2% in developed countries and, despite outcome improvement over the past 30 years, HF still entails overall a poor prognosis, comparable to cancer [ 1 – 3 ]. The latest European data on …

verfasst von:
Patrick Wiech, Laura Würzburger, Valentina A. Rossi, MD, Stefano Caselli, MD, PhD, Christian M. Schmied, MD, David Niederseer, MD, PhD, BSc, FESC

Open Access 24.03.2023 | perspective

Homeopathy—A lively relic of the prescientific era

Homeopathy was first postulated by the German physician Samuel Hahnemann in 1796 and 220 years later homeopathy is the most popular and widespread alternative medicine. Partly, it is also part of the national healthcare and insurance systems but …

verfasst von:
Yannick Borkens, Udo Endruscheit, Christian W. Lübbers