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Wiener klinische Wochenschrift OnlineFirst articles

23.09.2020 | original article

Association between psoriasis, psoriatic arthritis and gastrointestinal disease

An exploratory nationwide inpatient sample analysis

Psoriasis is a chronic, recurrent, immune-mediated inflammatory disorder with an estimated prevalence of 2–4% in western countries [ 1 – 3 ]. First presentation of psoriasis follows a bimodal distribution, peaking at ages 15–20 years and ages 55–60 …

BA Ahmed Yousaf, BS Rahul Raiker, PhD Stephen M. Davis, MD Swapna Gayam, MD Zachary Zinn

22.09.2020 | original article Open Access

Effects of a structured exercise program on physical performance and function, quality of life and work ability of physically active breast cancer survivors

A retrospective data analysis

In the early years of research on the effects of exercise in breast cancer survivors (BCS), the first resistance exercise stimulus which was investigated was dragon boat paddling [ 1 ]. Back then, it was feared that vigorous and repetitive loading …

Timothy Hasenöhrl, Stefano Palma, Dominikus F. -X. Huber, Andrej Zdravkovic, Richard Crevenna

18.09.2020 | main topic

SARS-CoV-2: recommendations for treatment in intensive care medicine

Coronavirus disease 2019 (COVID-19) progresses mildly in most of the cases; however, about 5% of the patients develop a severe acute respiratory distress syndrome (ARDS). Of all COVID-19 patients 3% need intensive care treatment, which becomes a …

Dr. Markus Köstenberger, Prim. Univ.-Prof. Dr. Walter Hasibeder, Dr. Daniel Dankl, Prim. Univ.-Doz. Dr. Reinhard Germann, Prim. Assoc. Prof. Dr. Christoph Hörmann, Univ.-Prof. Dr. Michael Joannidis, Univ.-Prof. Dr. Klaus Markstaller, Dr. Steve-Oliver Müller-Muttonen, Dr. Stefan Neuwersch-Sommeregger, Assoc. Prof. PD Dr. Eva Schaden, Univ.-Prof. Dr. Thomas Staudinger, Ao. Univ.-Prof. Dr. Roman Ullrich, MBA Prim. Univ.-Prof. Dr. Andreas Valentin, Prim. Univ.-Prof. Dr. Rudolf Likar

18.09.2020 | original article Open Access

Morphometric parameters of muscle and bone in critically ill patients

Post hoc analysis of the VITdAL-ICU trial

Sarcopenia, characterized as reduction in skeletal muscle mass and strength, can compromise physical function and quality of life. In the literature there are heterogenous definitions of sarcopenia: however, a worldwide widely used definition was …

Autoren: Oliver Malle, Dietmar Maurer, PD Doris Wagner, et Christian Schnedl, Steven Amrein, Univ.-Prof. Thomas Pieber, Univ. Doz. Astrid Fahrleitner-Pammer, Univ.-Prof. Hans Peter Dimai, Assoz. Prof. PD Dr. med.univ. Karin Amrein

18.09.2020 | original article

A data-driven framework for introducing predictive analytics into expanded program on immunization in Pakistan

A global vaccination program, also known as Expanded Program on Immunization (EPI), was started by the World Health Organization (WHO) in 1974 to make vaccines available to all children to protect them from 10 deadly childhood diseases: …

Sadaf Qazi, Muhammad Usman, Azhar Mahmood

18.09.2020 | short report

CDC25c expression in patients with myelofibrosis is associated with stronger myeloproliferation and shorter overall survival

Myelofibrosis is a malignant myeloproliferative neoplasm characterized by excess production of myeloid cells, development of bone marrow (BM) fibrosis and high risk of transformation to acute leukemia. Most of patients bear either of Janus kinase 2 … (

MD Davor Galusic, MD, PhD Marko Lucijanic, PhD Ana Livun, MD, PhD Prof. Maja Radman, MD Jelena Lucijanic, PhD Prof. Irena Drmic Hofman, MD, PhD Prof. Rajko Kusec

15.09.2020 | original article Open Access

Open-label phase II study evaluating safety and efficacy of the non-steroidal farnesoid X receptor agonist PX-104 in non-alcoholic fatty liver disease

Non-alcoholic fatty liver disease (NAFLD) and especially non-alcoholic steatohepatitis (NASH) are associated with a higher risk of progression to liver fibrosis, cirrhosis and hepatocellular carcinoma [ 1 – 3 ]. So far, no drug has been approved …

Stefan Traussnigg, Emina Halilbasic, Harald Hofer, Petra Munda, Tatjana Stojakovic, Günter Fauler, Karl Kashofer, Martin Krssak, Michael Wolzt, Michael Trauner

14.09.2020 | original article

Serum rheumatoid factor is correlated with liver fibrosis in patients with chronic hepatitis B

Hepatitis B virus (HBV) infections remain a serious public health problem despite the advances in prevention, diagnosis, and management [ 1 ]. Chronic hepatitis B (CHB) is a slowly progressive disease and characterized by liver fibrosis, and may …

M.D. Yusuf Coskun, Ilhami Yuksel

10.09.2020 | original article

Risk factors for development of vancomycin-resistant enterococcal bacteremia among VRE colonizers

A retrospective case control study

Enterococci are gram-positive and facultative anaerobic bacteria forming short chains. These microorganisms are natural members of intestinal flora in humans and animals. They cause a wide range of infections in humans: Enterococcus faecalis and E.

MD Abdurrahman Kaya, MD Sibel Yıldız Kaya, MD Assoc Prof Ilker Inanç Balkan, MD Osman Faruk Bayramlar, MD Assoc Prof Bilgül Mete, MD Prof Neşe Saltoglu, MD Prof Gökhan Aygün, MD Prof Ömer Fehmi Tabak

03.09.2020 | original article Open Access

Patient satisfaction after breast cancer surgery

A prospective clinical trial

The female breast plays an important role in society and in the lives of individual women. Besides its physiological role in breastfeeding, it is culturally associated with womanhood and fertility and represents a prominent secondary sex …

MD, PhD Carmen Leser, Yen Y. Tan, Christian Singer, Robert Zeillinger, Florian Fitzal, Johann Lehrner, Daniel König, Christine Deutschmann, Daphne Gschwantler-Kaulich

02.09.2020 | review article

Determinants of health and well-being in adolescents

Review of sex differences with a focus on boys

A wide variety of variables determine health and well-being in adolescence. How these variables may differ in relation to gender or sex is often not clear. In addition, research on sex differences often focuses on females rather than males. This …

Gloria Mittmann, Beate Schrank

02.09.2020 | original article

HS-173, a selective PI3K inhibitor, induces cell death in head and neck squamous cell carcinoma cell lines

Head and neck squamous cell carcinoma (HNSCC) refers to a group of tumors derived from the squamous epithelium of the oral cavity, pharynx and larynx. A limited range of important therapeutic advances have been achieved during the last years …

MD Elisabeth Foki, MD Isabella Stanisz, MD Lorenz Kadletz, MD Ulana Kotowski, MD, DMD, MSc, MBA Rudolf Seemann, MD Rainer Schmid, MD, PD Gregor Heiduschka

20.08.2020 | main topic Open Access

Emergence of coronavirus disease 2019 (COVID-19) in Austria

This is a report on the first identified cases of coronavirus disease 2019 (COVID-19) in Austria. The first documented case was a person who stayed in Kühtai, Tyrol, from 24 to 26 January 2020, and had been infected by a Chinese instructor in …

Peter Kreidl, Daniela Schmid, Sabine Maritschnik, Lukas Richter, Wegene Borena, Jakob-Wendelin Genger, Alexandra Popa, Thomas Penz, Christoph Bock, Andreas Bergthaler, Univ. Prof. Dr. Franz Allerberger

10.08.2020 | main topic

Hydroxychloroquine versus lopinavir/ritonavir in severe COVID-19 patients

Results from a real-life patient cohort

As of 30 June 2020 the SARS-CoV‑2 pandemic has caused over 10 million infections and over 500,000 deaths worldwide [ 1 ]. The clinical manifestation of COVID-19 ranges from mild respiratory symptoms to acute respiratory distress syndrome and death.

Mario Karolyi, Erich Pawelka, Theresa Mader, Sara Omid, Hasan Kelani, Sarah Ely, Bernd Jilma, Sebastian Baumgartner, Hermann Laferl, Clemens Ott, Marianna Traugott, Michael Turner, Tamara Seitz, Christoph Wenisch, Alexander Zoufaly

06.08.2020 | original article

Retinal pigment epithelial characteristics in eyes with neovascular age-related macular degeneration

Long-term retinal changes under anti-vascular endothelial growth factor treatment

Age-related macular degeneration (AMD) is the leading cause of irreversible central vision loss in adults over 50 years of age in the western world [ 1 , 2 ]. Intravitreally applied vascular endothelial growth factor (VEGF) inhibitors are presently …

MD Christian Ebner, MD Clara Wernigg, MD, PhD, PD Christopher Schütze, MD, PD Birgit Weingessel, MD, MBA Prof. Pia-Veronika Vécsei-Marlovits

04.08.2020 | original article

Epidemiological characteristics, clinical and laboratory findings supporting preliminary diagnosis of Crimean-Congo hemorrhagic fever in an endemic region in Turkey

Crimean-Congo hemorrhagic fever (CCHF) is a tick-borne zoonotic disease caused by the CCHF virus belonging to the genus Nairovirus of the Bunyaviridae family [ 1 – 4 ]. The disease is acquired by an infected tick bite or transmitted from blood/body …

Zuhal Yeşilbağ, Aslı Karadeniz, Safiye Koçulu, Cahit Bekir Kayhan

30.07.2020 | main topic

Partially ionized medical oxygen as a supplementary treatment for COVID-19

Dear Editors …

Slavomír Perečinský, Viliam Donič, Ľubomír Legáth

24.07.2020 | main topic

COVID-19: frequently asked questions to the cardiologist

MD, PhD Andreas A. Kammerlander, ao. Univ. Prof. Dr. Julia Mascherbauer

22.07.2020 | original article

Psoriasis and IgE-mediated allergy: correlation or mutual inhibition?

A prospective cohort study in patients with mild or moderate to severe psoriasis

Psoriasis vulgaris is a chronic autoimmune skin disease characterized by keratinocyte hyperproliferation and chronic inflammation [ 1 ], which affects 1–3% of the world population [ 2 ]. Although the etiology is not completely understood, the …

Anna Essl, Dagmara Loader, Robert Feldmann, Andreas Steiner, Dr. Paul Sator

20.07.2020 | review article Open Access

Health effects of electronic cigarette (e‑cigarette) use on organ systems and its implications for public health

Electronic nicotine delivery systems, known commonly as electronic cigarettes or e‑cigarettes, are hand-held battery-powered devices simulating the structural, behavioral and arguably physiological aspects of traditional smoking [ 1 ]. In each of …

M. A., M.Sc. Radhika Seiler-Ramadas, Isabell Sandner, Mag.rer.nat., PhD Sandra Haider, Igor Grabovac, Dr. MPH Assoc. Prof. Thomas Ernst Dorner