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Wiener klinische Wochenschrift OnlineFirst articles

14.08.2019 | consensus report Open Access

Recommendations for ibrutinib treatment in patients with atrial fibrillation and/or elevated cardiovascular risk

Ibrutinib is the first clinically approved inhibitor of Bruton’s tyrosine kinase, an enzyme that is essential for survival and proliferation of B‑cells by activating the B‑cell receptor signalling pathway. Ibrutinib has been shown to be highly …

Markus C. Stühlinger, Ansgar Weltermann, Philipp Staber, Daniel Heintel, Thomas Nösslinger, Michael Steurer

06.08.2019 | Correction

Erratum zu: Therapie der akuten diabetischen Stoffwechselentgleisungen bei Erwachsenen (Update 2019)

Erratum zu: Wien Klin Wochenschr 2018 Die Originalversion des Beitrags enthielt leider einen Fehler in Tab. 3. In der publizierten Version war in der 1. Spalte PO4 im Plasma mit 0 und Mg mit 1,25 …

Susanne Kaser, Harald Sourij, Martin Clodi, Bruno Schneeweiß, Anton N. Laggner, Anton Luger

02.08.2019 | original article

Prevalence of palliative care patients in emergency departments

The main focus of emergency medicine is the identification and stabilization of patients’ acute conditions, with the emphasis on rapid interventions as well as initiation of necessary procedures and treatment [ 1 ]. The emergency department (ED) …

MD Markus Köstenberger, MD Stefan Neuwersch, MD Dietmar Weixler, Dr. Wolfgang Pipam, MD Michael Zink, MD PhD Rudolf Likar

18.07.2019 | original article Open Access

The Austrian biodatabase for chronic myelomonocytic leukemia (ABCMML)

A representative and useful real-life data source for further biomedical research

In the Austrian biodatabase for chronic myelomonocytic leukemia (ABCMML) clinicolaboratory real-life data have been captured from 606 CMML patients from 14 different hospitals over the last 30 years. It is the only large biodatabase worldwide in …

Univ. Prof. Dr. Klaus Geissler, Eva Jäger, Agnes Barna, Michael Gurbisz, Renate Marschon, Temeida Graf, Elmir Graf, Bojana Borjan, Ruth Jilch, Christoph Geissler, Gregor Hoermann, Harald Esterbauer, Ilse Schwarzinger, Thomas Nösslinger, Michael Pfeilstöcker, Heinz Tüchler, Regina Reisner, Thamer Sliwa, Felix Keil, Peter Bettelheim, Sigrid Machherndl-Spandl, Bernhard Doleschal, Otto Zach, Ansgar Weltermann, Sonja Heibl, Josef Thaler, Armin Zebisch, Heinz Sill, Reinhard Stauder, Gerald Webersinke, Andreas Petzer, Rajko Kusec, Ernst Ulsperger, Bruno Schneeweiss, Jörg Berger, Leopold Öhler, Ulrich Germing, Wolfgang R. Sperr, Paul Knöbl, Ulrich Jäger, Peter Valent

16.07.2019 | original article

Does third trimester cervical length predict duration of first stage of labor?

Preterm birth is a major issue worldwide and is associated with a massive morbidity and mortality for mother and child [ 1 ]. Risk factors are multifactorial and predominantly include infections, smoking, vaginal bleeding, lower socioeconomic …

MD György Léhner, MD Philipp Reif, PhD Alexander Avian, MD Martina Kollmann, MD Ioana-Claudia Lakovschek, MD Uwe Lang, MD, PhD Daniela Ulrich

16.07.2019 | main topic Open Access

Challenges in rehabilitation of patients with nontraumatic spinal cord dysfunction due to tumors

A narrative review

The incidence of cancer-associated non-traumatic spinal cord dysfunction is rising due to population aging and better cancer treatment. The overall benefit of rehabilitation in specialized facilities for traumatic spinal cord dysfunction has been …

Anna Pataraia, Richard Crevenna

02.07.2019 | main topic Open Access

Typical aspects in the rehabilitation of cancer patients suffering from metastatic bone disease or multiple myeloma

Modern cancer and hemato-oncological treatment results in improvement of survival of patients suffering from metastatic cancer or multiple myeloma [ 1 – 6 ]. As patients survive longer, health-related quality of life (HRQOL), social and …

Mohammad Keilani, Franz Kainberger, Anna Pataraia, Timothy Hasenöhrl, Barbara Wagner, Stefano Palma, Fadime Cenik, MBA, MMSc Univ. Prof. Dr. Richard Crevenna

02.07.2019 | short report

Hereditary methemoglobinemia caused by Hb M-Hyde Park (Hb M-Akita) (HBB:c.277C > T; p.His93Tyr)

Healthy human blood contains only a trace amount of methemoglobin (Hb M), less than 1%. In Hb M iron is present in the oxidized ferric state (Fe3+) not in the reduced ferrous form (Fe2+) and this reduces the ability of hemoglobin to bind oxygen.

Dr. Wolfgang J. Schnedl, Robert Queissner, Michael Schenk, Dietmar Enko, Harald Mangge

24.06.2019 | main topic Open Access

Outcomes research in non-specific low back pain

Knowledge transfer in clinical practice

Due to the increased longevity of the population in industrialized countries, global priorities in healthcare have been shifting from communicable to non-communicable diseases [ 1 ]. Musculoskeletal conditions are the main burden of …

PhD, MSc, MBA Univ. Prof. Mag. Dr. Tanja A. Stamm, Anna Boesendorfer, Maisa Omara, Valentin Ritschl, Siniša Štefanac, Erika Mosor

18.06.2019 | original article

Is there a clinical difference between influenza A and B virus infections in hospitalized patients?

Results after routine polymerase chain reaction point-of-care testing in the emergency room from 2017/2018

Influenza infections occur in seasonal outbreaks during the winter period related to cold or humid weather conditions and are associated with an excess hospitalization and an increase in overall mortality [ 1 , 9 ]. Due to a lack of accurate …

Mario Karolyi, Dr. Erich Pawelka, Simon Daller, Caroline Kaczmarek, Hermann Laferl, Iulia Niculescu, Birte Schrader, Christian Stütz, Alexander Zoufaly, Christoph Wenisch

14.06.2019 | main topic Open Access

Bionic reconstruction

Restoration of extremity function with osseointegrated and mind-controlled prostheses

The human upper extremity and especially its most distal part, the hand, is essential for interacting with otheur environment. Due to its rich sensorimotor innervation and the resulting fine motor control, multiple degrees of freedom and …

M.D. Martin Aman, Christopher Festin, M.D. Matthias E. Sporer, M.D. Clemens Gstoettner, M.Sc. Cosima Prahm, M.D. Ph.D Konstantin D. Bergmeister, M.D. Oskar C. Aszmann

12.06.2019 | original article

Evaluation of pulmonary venous variations in a large cohort

Multidetector computed tomography study with new variations

Variant anatomy of pulmonary vasculature has been a popular research topic in the fields of cardiology, thoracic surgery and radiology, as ectopic atrial beats may originate from pulmonary veins and variant veins are the potential cause of …

MD Derya Altinkaynak, MD Asli Koktener

07.06.2019 | original article Open Access

Fine and ultrafine particle exposure during commuting by subway in Vienna

Mass concentrations of particulate matter (PM10, PM2.5, PM1), lung deposited surface area and particle number concentrations were measured for the first time in all Viennese subway lines inside cabins and in two subway stations, one aboveground …

Klaus-Peter Posselt, M.D. Prof. Manfred Neuberger, David Köhler

23.05.2019 | original article

Childhood tuberculosis in Vienna between 2010 and 2016

Tuberculosis (TB) is an infectious disease caused by bacteria of the Mycobacterium tuberculosis complex. It is still one of the top ten causes of death worldwide and the leading cause of death from a single infectious agent [ 1 ]. Although …

Max Unterweger, Florian Götzinger, Matthias Bogyi, Angela Zacharasiewicz, Clemens Mädel, Kerstin Tiringer, Matthias Reinweber, Prim. Univ.-Prof. Mag. Dr. Thomas Frischer

16.05.2019 | original article Open Access

How many women take oral supplementation in pregnancy in Austria?

Who recommended it? A cross-sectional study

Iron deficiency anemia is the most common form of anemia in pregnancy and is usually hypochromic and microcytic [ 1 ] and associated with a low level of ferritin. According to the World Health Organization (WHO), its prevalence during pregnancy is …

Ulrike Spary-Kainz, Thomas Semlitsch, Sophie Rundel, Alexander Avian, Sereina Herzog, Heidelinde Jakse, Andrea Siebenhofer

13.05.2019 | short report Open Access

Alpha-gal allergy after a tick bite in Austria

Tick bites can cause the alpha-gal syndrome, which is characterized by delayed anaphylactic reactions mainly to red meat and offal due to IgE antibodies against mammalian galactose-alpha-1.3-galactose carbohydrate (alpha-gal). Ixodes ricinus bites …

Veronika Pisazka, Georg Duscher, Adnan Hodžić, Norbert Reider, MD Univ. Prof. Dr. Franz Allerberger

13.05.2019 | main topic Open Access

Role of physical medicine for cancer rehabilitation and return to work under the premise of the “Wiedereingliederungsteilzeitgesetz”

Modern cancer care with increasing survival rates puts the focus on return to work in the cancer survivorship. Cancer rehabilitation has a key role in improving patients’ quality of life, functional performance and participation. These factors …

Fadime Cenik, Bruno Mähr, Stefano Palma, Mohammad Keilani, Thomas Nowotny, MBA, MSc Univ. Prof. Dr. Richard Crevenna

13.05.2019 | comment

Parental obligation to vaccinate children under Austrian civil law?

With reference to a decision of the European Court of Human Rights (ECHR) from 2012, legal experts state that compulsory vaccination enforced by the state would not represent a violation of human rights. From a legal perspective, its introduction …

Hannah Groman

10.05.2019 | Lyme Borreliosis

Evaluation of the clinical relevance of vancomycin for the treatment of Lyme disease

Vancomycin is active in vitro and in vivo in mouse systems against Lyme disease borrelia; however, there are no published data on the efficacy of vancomycin in patients with Lyme disease and no convincing theoretical advantages of vancomycin over …

M.D. Dr. Gary P. Wormser, M.D. Dr. Alan G. Barbour

06.05.2019 | Lyme Borreliosis Open Access

Tick saliva and its role in pathogen transmission

Tick saliva is a complex mixture of peptidic and non-peptidic molecules that aid engorgement. The composition of tick saliva changes as feeding progresses and the tick counters the dynamic host response. Ixodid ticks such as Ixodes ricinus, the …

Patricia A. Nuttall