Ibrutinib is the first clinically approved inhibitor of Bruton’s tyrosine kinase, an enzyme that is essential for survival and proliferation of B‑cells by activating the B‑cell receptor signalling pathway. Ibrutinib has been shown to be highly …
Autoren:
Markus C. Stühlinger, Ansgar Weltermann, Philipp Staber, Daniel Heintel, Thomas Nösslinger, Michael Steurer
Erratum zu: Wien Klin Wochenschr 2018 https://doi.org/10.1007/s00508-018-1423-z Die Originalversion des Beitrags enthielt leider einen Fehler in Tab. 3. In der publizierten Version war in der 1. Spalte PO4 im Plasma mit 0 und Mg mit 1,25 …
Autoren:
Susanne Kaser, Harald Sourij, Martin Clodi, Bruno Schneeweiß, Anton N. Laggner, Anton Luger
The main focus of emergency medicine is the identification and stabilization of patients’ acute conditions, with the emphasis on rapid interventions as well as initiation of necessary procedures and treatment [ 1 ]. The emergency department (ED) …
Autoren:
MD Markus Köstenberger, MD Stefan Neuwersch, MD Dietmar Weixler, Dr. Wolfgang Pipam, MD Michael Zink, MD PhD Rudolf Likar
A representative and useful real-life data source for further biomedical research
In the Austrian biodatabase for chronic myelomonocytic leukemia (ABCMML) clinicolaboratory real-life data have been captured from 606 CMML patients from 14 different hospitals over the last 30 years. It is the only large biodatabase worldwide in …
Autoren:
Univ. Prof. Dr. Klaus Geissler, Eva Jäger, Agnes Barna, Michael Gurbisz, Renate Marschon, Temeida Graf, Elmir Graf, Bojana Borjan, Ruth Jilch, Christoph Geissler, Gregor Hoermann, Harald Esterbauer, Ilse Schwarzinger, Thomas Nösslinger, Michael Pfeilstöcker, Heinz Tüchler, Regina Reisner, Thamer Sliwa, Felix Keil, Peter Bettelheim, Sigrid Machherndl-Spandl, Bernhard Doleschal, Otto Zach, Ansgar Weltermann, Sonja Heibl, Josef Thaler, Armin Zebisch, Heinz Sill, Reinhard Stauder, Gerald Webersinke, Andreas Petzer, Rajko Kusec, Ernst Ulsperger, Bruno Schneeweiss, Jörg Berger, Leopold Öhler, Ulrich Germing, Wolfgang R. Sperr, Paul Knöbl, Ulrich Jäger, Peter Valent
Preterm birth is a major issue worldwide and is associated with a massive morbidity and mortality for mother and child [ 1 ]. Risk factors are multifactorial and predominantly include infections, smoking, vaginal bleeding, lower socioeconomic …
Autoren:
MD György Léhner, MD Philipp Reif, PhD Alexander Avian, MD Martina Kollmann, MD Ioana-Claudia Lakovschek, MD Uwe Lang, MD, PhD Daniela Ulrich
The incidence of cancer-associated non-traumatic spinal cord dysfunction is rising due to population aging and better cancer treatment. The overall benefit of rehabilitation in specialized facilities for traumatic spinal cord dysfunction has been …
Modern cancer and hemato-oncological treatment results in improvement of survival of patients suffering from metastatic cancer or multiple myeloma [ 1 – 6 ]. As patients survive longer, health-related quality of life (HRQOL), social and …
Autoren:
Mohammad Keilani, Franz Kainberger, Anna Pataraia, Timothy Hasenöhrl, Barbara Wagner, Stefano Palma, Fadime Cenik, MBA, MMSc Univ. Prof. Dr. Richard Crevenna
Healthy human blood contains only a trace amount of methemoglobin (Hb M), less than 1%. In Hb M iron is present in the oxidized ferric state (Fe3+) not in the reduced ferrous form (Fe2+) and this reduces the ability of hemoglobin to bind oxygen.
Autoren:
Dr. Wolfgang J. Schnedl, Robert Queissner, Michael Schenk, Dietmar Enko, Harald Mangge
Due to the increased longevity of the population in industrialized countries, global priorities in healthcare have been shifting from communicable to non-communicable diseases [ 1 ]. Musculoskeletal conditions are the main burden of …
Autoren:
PhD, MSc, MBA Univ. Prof. Mag. Dr. Tanja A. Stamm, Anna Boesendorfer, Maisa Omara, Valentin Ritschl, Siniša Štefanac, Erika Mosor
Results after routine polymerase chain reaction point-of-care testing in the emergency room from 2017/2018
Influenza infections occur in seasonal outbreaks during the winter period related to cold or humid weather conditions and are associated with an excess hospitalization and an increase in overall mortality [ 1 , 9 ]. Due to a lack of accurate …
Autoren:
Mario Karolyi, Dr. Erich Pawelka, Simon Daller, Caroline Kaczmarek, Hermann Laferl, Iulia Niculescu, Birte Schrader, Christian Stütz, Alexander Zoufaly, Christoph Wenisch
Restoration of extremity function with osseointegrated and mind-controlled prostheses
The human upper extremity and especially its most distal part, the hand, is essential for interacting with otheur environment. Due to its rich sensorimotor innervation and the resulting fine motor control, multiple degrees of freedom and …
Autoren:
M.D. Martin Aman, Christopher Festin, M.D. Matthias E. Sporer, M.D. Clemens Gstoettner, M.Sc. Cosima Prahm, M.D. Ph.D Konstantin D. Bergmeister, M.D. Oskar C. Aszmann
Multidetector computed tomography study with new variations
Variant anatomy of pulmonary vasculature has been a popular research topic in the fields of cardiology, thoracic surgery and radiology, as ectopic atrial beats may originate from pulmonary veins and variant veins are the potential cause of …
Mass concentrations of particulate matter (PM10, PM2.5, PM1), lung deposited surface area and particle number concentrations were measured for the first time in all Viennese subway lines inside cabins and in two subway stations, one aboveground …
Autoren:
Klaus-Peter Posselt, M.D. Prof. Manfred Neuberger, David Köhler
Tuberculosis (TB) is an infectious disease caused by bacteria of the Mycobacterium tuberculosis complex. It is still one of the top ten causes of death worldwide and the leading cause of death from a single infectious agent [ 1 ]. Although …
Autoren:
Max Unterweger, Florian Götzinger, Matthias Bogyi, Angela Zacharasiewicz, Clemens Mädel, Kerstin Tiringer, Matthias Reinweber, Prim. Univ.-Prof. Mag. Dr. Thomas Frischer
Iron deficiency anemia is the most common form of anemia in pregnancy and is usually hypochromic and microcytic [ 1 ] and associated with a low level of ferritin. According to the World Health Organization (WHO), its prevalence during pregnancy is …
Autoren:
Ulrike Spary-Kainz, Thomas Semlitsch, Sophie Rundel, Alexander Avian, Sereina Herzog, Heidelinde Jakse, Andrea Siebenhofer
Tick bites can cause the alpha-gal syndrome, which is characterized by delayed anaphylactic reactions mainly to red meat and offal due to IgE antibodies against mammalian galactose-alpha-1.3-galactose carbohydrate (alpha-gal). Ixodes ricinus bites …
Autoren:
Veronika Pisazka, Georg Duscher, Adnan Hodžić, Norbert Reider, MD Univ. Prof. Dr. Franz Allerberger
Modern cancer care with increasing survival rates puts the focus on return to work in the cancer survivorship. Cancer rehabilitation has a key role in improving patients’ quality of life, functional performance and participation. These factors …
Autoren:
Fadime Cenik, Bruno Mähr, Stefano Palma, Mohammad Keilani, Thomas Nowotny, MBA, MSc Univ. Prof. Dr. Richard Crevenna
With reference to a decision of the European Court of Human Rights (ECHR) from 2012, legal experts state that compulsory vaccination enforced by the state would not represent a violation of human rights. From a legal perspective, its introduction …
Vancomycin is active in vitro and in vivo in mouse systems against Lyme disease borrelia; however, there are no published data on the efficacy of vancomycin in patients with Lyme disease and no convincing theoretical advantages of vancomycin over …
Autoren:
M.D. Dr. Gary P. Wormser, M.D. Dr. Alan G. Barbour
Tick saliva is a complex mixture of peptidic and non-peptidic molecules that aid engorgement. The composition of tick saliva changes as feeding progresses and the tick counters the dynamic host response. Ixodid ticks such as Ixodes ricinus, the …