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Wiener klinische Wochenschrift OnlineFirst articles

16.10.2019 | original article

Olaratumab plus anthracyline in advanced/metastatic soft tissue sarcoma

Data of real-world utilization in Austria

Soft tissue sarcomas (STS) are a rare and heterogeneous group of solid tumors originating from mesenchymal precursors and comprise less than 1% of all newly diagnosed adult malignancies [ 1 ]. The STS present as a wide histopathological spectrum …

Autoren:
MD PhD Andreas Seeber, Lukas Weiss, Franz Romeder, Joanna Szkandera, Thomas Kuehr, Susanne Kostner, Petra Pichler, Thomas Jaeger, Florian Kocher, Richard Greil, Thomas Brodowicz

14.10.2019 | original article

Medical radiation exposure from radiological and interventional procedures in Austria

Since 1988 the number of diagnostic (plain radiography, fluoroscopy, computed tomography [CT]) and interventional procedures involving X‑rays and the associated collective dose has risen sharply internationally. One of the factors that contributed …

Autoren:
David Wachabauer, Stefan Mathis-Edenhofer, Hanns Moshammer

01.10.2019 | original article Open Access

Retrospective qualitative pilot study incorporating patients’ personal life aspects on admission to palliative care

What should we know about patients to give them the best possible care?

Taking a medical history mostly focuses on physical and health-related aspects of patients. Medical professionals ask about current symptoms, about former illnesses and record current medications, physical function, mental health, and family …

Autoren:
MD Anna Kitta, MD Feroniki Adamidis, MD, Ph.D. Matthias Unseld, MD Herbert H. Watzke, MD, Ph.D., MSc Eva Katharina Masel

23.09.2019 | review article Open Access

What is new in the 2018 ESC guidelines for the management of cardiovascular diseases during pregnancy?

Cardiovascular diseases during pregnancy are the most common causes of pregnancy-associated mortality.Vaginal delivery is the preferred mode of birth in the majority of pregnancies.It is recommended that patients with modified World Health …

Autor:
MD Irene M. Lang

18.09.2019 | main topic Open Access

Establishing an online physical exercise program for people with hemophilia

Autoren:
Dr. Barbara Wagner, Dr. Axel Seuser, Dr. Steffen Krüger, M.A. Marie Luca Herzig, Univ.-Prof. Dr. Dr. Thomas Hilberg, Assoc. Prof. Priv.-Doz. Dr. Cihan Ay, MSc, BSc Timothy Hasenöhrl, MBA, MSc Univ.-Prof. Dr. Richard Crevenna

09.09.2019 | main topic Open Access

Analysis and quantification of bone healing after open wedge high tibial osteotomy

An open wedge osteotomy of the high tibia is a surgical technique to correct varus alignment of the lower limb caused by varus deformity of the tibia [ 1 – 3 ]. Osteosynthesis is performed using a locking plate to stabilize the osteotomy. The …

Autoren:
Elena Nemecek, Catharina Chiari, Alexander Valentinitsch, Franz Kainberger, Gerhard Hobusch, Alexander Kolb, Lena Hirtler, Carmen Trost, Slobodan Vukicevic, Prof. Dr. Reinhard Windhager

06.09.2019 | main topic Open Access

Association between low back pain and various everyday performances

Activities of daily living, ability to work and sexual function

Low back pain (LBP) is a widely prevalent chronic pain disorder associated with a high burden on individuals and society. In the subjective perception of patients with LBP, probably the most important health outcomes associated with LBP are those …

Autoren:
Igor Grabovac, MD, MPH Assoc.-Prof. PD Dr. med. univ. Thomas Ernst Dorner

14.08.2019 | consensus report Open Access

Recommendations for ibrutinib treatment in patients with atrial fibrillation and/or elevated cardiovascular risk

Ibrutinib is the first clinically approved inhibitor of Bruton’s tyrosine kinase, an enzyme that is essential for survival and proliferation of B‑cells by activating the B‑cell receptor signalling pathway. Ibrutinib has been shown to be highly …

Autoren:
Markus C. Stühlinger, Ansgar Weltermann, Philipp Staber, Daniel Heintel, Thomas Nösslinger, Michael Steurer

16.07.2019 | main topic Open Access

Challenges in rehabilitation of patients with nontraumatic spinal cord dysfunction due to tumors

A narrative review

The incidence of cancer-associated non-traumatic spinal cord dysfunction is rising due to population aging and better cancer treatment. The overall benefit of rehabilitation in specialized facilities for traumatic spinal cord dysfunction has been …

Autoren:
Anna Pataraia, Richard Crevenna

02.07.2019 | main topic Open Access

Typical aspects in the rehabilitation of cancer patients suffering from metastatic bone disease or multiple myeloma

Modern cancer and hemato-oncological treatment results in improvement of survival of patients suffering from metastatic cancer or multiple myeloma [ 1 – 6 ]. As patients survive longer, health-related quality of life (HRQOL), social and …

Autoren:
Mohammad Keilani, Franz Kainberger, Anna Pataraia, Timothy Hasenöhrl, Barbara Wagner, Stefano Palma, Fadime Cenik, MBA, MMSc Univ. Prof. Dr. Richard Crevenna

24.06.2019 | main topic Open Access

Outcomes research in non-specific low back pain

Knowledge transfer in clinical practice

Due to the increased longevity of the population in industrialized countries, global priorities in healthcare have been shifting from communicable to non-communicable diseases [ 1 ]. Musculoskeletal conditions are the main burden of …

Autoren:
PhD, MSc, MBA Univ. Prof. Mag. Dr. Tanja A. Stamm, Anna Boesendorfer, Maisa Omara, Valentin Ritschl, Siniša Štefanac, Erika Mosor

14.06.2019 | main topic Open Access

Bionic reconstruction

Restoration of extremity function with osseointegrated and mind-controlled prostheses

The human upper extremity and especially its most distal part, the hand, is essential for interacting with otheur environment. Due to its rich sensorimotor innervation and the resulting fine motor control, multiple degrees of freedom and …

Autoren:
M.D. Martin Aman, Christopher Festin, M.D. Matthias E. Sporer, M.D. Clemens Gstoettner, M.Sc. Cosima Prahm, M.D. Ph.D Konstantin D. Bergmeister, M.D. Oskar C. Aszmann

10.05.2019 | Lyme Borreliosis

Evaluation of the clinical relevance of vancomycin for the treatment of Lyme disease

Vancomycin is active in vitro and in vivo in mouse systems against Lyme disease borrelia; however, there are no published data on the efficacy of vancomycin in patients with Lyme disease and no convincing theoretical advantages of vancomycin over …

Autoren:
M.D. Dr. Gary P. Wormser, M.D. Dr. Alan G. Barbour

06.05.2019 | Lyme Borreliosis Open Access

Tick saliva and its role in pathogen transmission

Tick saliva is a complex mixture of peptidic and non-peptidic molecules that aid engorgement. The composition of tick saliva changes as feeding progresses and the tick counters the dynamic host response. Ixodid ticks such as Ixodes ricinus, the …

Autor:
Patricia A. Nuttall