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04.10.2021 | review

Is thymus and activation-regulated chemokine a forgotten diagnostic and minimal residual disease marker in classical Hodgkin lymphoma?

A chronological narrative literature review

verfasst von: Wael Khair, MD

Erschienen in: memo - Magazine of European Medical Oncology | Ausgabe 4/2021

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Summary

Objective

The objective of this paper is to elucidate the role of thymus and activation-regulated chemokine (TARC) as a marker of treatment response in classical Hodgkin lymphoma (cHL).

Background

Most patients diagnosed with cHL can be cured today but about 20–30% still experience refractoriness/relapse. Positron emission tomography (PET) has been shown to not be the optimal tool, since 15–20% of patients relapse despite negative PET. There is an unmet need for new markers to predict response to treatment as early as possible and for surveillance of patients after completion of treatment to allow prompt intervention in case of signs of evolving relapse.

Methods

Literature regarding the role of thymus and activation-regulated chemokine (TARC) in cHL was searched and 13 studies between 2005 and 2020 with a total of 1433 patients were identified and reviewed.

Conclusion

Reviewed studies suggest that TARC is one of the most promising markers, which can be used to improve treatment outcome in cHL.

Vorheriger Artikel Ponatinib and palbociclib combination in TKI-resistant CML—A case report

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Titel: Is thymus and activation-regulated chemokine a forgotten diagnostic and minimal residual disease marker in classical Hodgkin lymphoma?
A chronological narrative literature review
verfasst von: Wael Khair, MD
Publikationsdatum: 04.10.2021
Verlag: Springer Vienna
Erschienen in: memo - Magazine of European Medical Oncology / Ausgabe 4/2021
Print ISSN: 1865-5041
Elektronische ISSN: 1865-5076
DOI: https://doi.org/10.1007/s12254-021-00753-x

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Is thymus and activation-regulated chemokine a forgotten diagnostic and minimal residual disease marker in classical Hodgkin lymphoma?

A chronological narrative literature review

Summary

Objective

Background

Methods

Conclusion

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ASCO 2021—selection of personal highlights in early stage non-small cell lung cancer

Best of ASCO 2021: new data from triple-negative breast cancer

ASCO 2021–Gastroesophageal tumor highlights

Detection of acquired resistance mutation ALK G1202R after treatment with alectinib and response of lorlatinib

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