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Erschienen in: Wiener klinische Wochenschrift 15-16/2019

18.06.2019 | original article

Is there a clinical difference between influenza A and B virus infections in hospitalized patients?

Results after routine polymerase chain reaction point-of-care testing in the emergency room from 2017/2018

verfasst von: Mario Karolyi, Dr. Erich Pawelka, Simon Daller, Caroline Kaczmarek, Hermann Laferl, Iulia Niculescu, Birte Schrader, Christian Stütz, Alexander Zoufaly, Christoph Wenisch

Erschienen in: Wiener klinische Wochenschrift | Ausgabe 15-16/2019

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Summary

Purpose

The clinical presentation, complications and mortality in molecularly confirmed influenza A and B infections were analyzed.

Methods

This retrospective observational single-centre study included all influenza positive patients older than 18 years who were hospitalized and treated at the flu isolation ward during 2017/2018. The diagnosis was based on point-of-care tests with the AlereTM.

Results

Of the 396 patients tested positive for influenza, 24.2% had influenza A and 75.8% influenza B. Influenza A patients were younger (median age 67.5 years vs. 77 years, p < 0.001), were more often smokers (27.7% vs. 16.8%, p = 0.021), had chronic pulmonary diseases more frequently (39.6% vs. 26.3%, p = 0.013), presented with a higher body temperature (38.6 °C vs. 38.3 °C, p = 0.004), leucocyte count (8 G/L vs. 6.8 G/L, p = 0.002), C‑reactive protein (CRP) level (41 mg/l vs. 23 mg/l, p < 0.001) and had dyspnea more often (41.7% vs. 28%, p = 0.012). Influenza B patients had an underlying chronic kidney disease in 37% vs. 18.8% (p < 0.001) and presented with vomiting on admission more frequently (21.7% vs. 11.5%, p = 0.027). Influenza A patients were admitted for 8 days vs. 7 days (p = 0.023). There were no differences in the rate of complications; however, 22 (5.6%) patients died during the hospital stay. The in-hospital mortality was higher in influenza A patients (8.3% vs 4.7%, p = 0.172).

Conclusion

Some differences were found between influenza A and B virus infections but symptoms were overlapping, which necessitates polymerase chain reaction point-of-care testing for accurate diagnosis. Influenza A was a more severe disease than influenza B during the period 2017/2018.

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Metadaten
Titel
Is there a clinical difference between influenza A and B virus infections in hospitalized patients?
Results after routine polymerase chain reaction point-of-care testing in the emergency room from 2017/2018
verfasst von
Mario Karolyi
Dr. Erich Pawelka
Simon Daller
Caroline Kaczmarek
Hermann Laferl
Iulia Niculescu
Birte Schrader
Christian Stütz
Alexander Zoufaly
Christoph Wenisch
Publikationsdatum
18.06.2019
Verlag
Springer Vienna
Erschienen in
Wiener klinische Wochenschrift / Ausgabe 15-16/2019
Print ISSN: 0043-5325
Elektronische ISSN: 1613-7671
DOI
https://doi.org/10.1007/s00508-019-1519-0