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Erschienen in: memo - Magazine of European Medical Oncology 2/2012

01.06.2012 | case report

Is distinct EGFR mutation status proof of second simultaneous primary non-small cell lung cancer?

verfasst von: Ulf Petrausch, Verena Tischler, Walter Weder, Rolf Stahel, Alex Soltermann

Erschienen in: memo - Magazine of European Medical Oncology | Ausgabe 2/2012

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Abstract

We present the case of a 54-year-old woman diagnosed with two simultaneous adenocarcinomas in the right and left upper lobe of the lungs. The patient was treated with two curative intended resections and chemotherapy. The molecular analysis showed distinct EGFR mutation pattern in both adenocarcinomas of the lung. During the clinical course, the adenocarcinoma without EGFR mutation relapsed multiple times in the right lung resulting finally in pneumonectomy in 2009. Since then, the patient had no indication of relapse. The case demonstrates the difficulty to clinically discriminate a palliative metastatic situation from a potential curable situation with two simultaneous primary adenocarcinomas of the lung. We propose that a different molecular pattern between lesions could be used as an argument for the presence of two simultaneous primary tumors. In the case of distinct EGFR mutation pattern, therapy could be performed with curative intent.
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Metadaten
Titel
Is distinct EGFR mutation status proof of second simultaneous primary non-small cell lung cancer?
verfasst von
Ulf Petrausch
Verena Tischler
Walter Weder
Rolf Stahel
Alex Soltermann
Publikationsdatum
01.06.2012
Verlag
Springer Vienna
Erschienen in
memo - Magazine of European Medical Oncology / Ausgabe 2/2012
Print ISSN: 1865-5041
Elektronische ISSN: 1865-5076
DOI
https://doi.org/10.1007/s12254-012-0026-z

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