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08.09.2017 | main topic | Ausgabe 3-4/2018 Open Access

Wiener Medizinische Wochenschrift 3-4/2018

Intestinal microbiome-gut-brain axis and irritable bowel syndrome

Wiener Medizinische Wochenschrift > Ausgabe 3-4/2018
MD Univ. Prof. Dr. Gabriele Moser, MD Camille Fournier, M.Sc. Johannes Peter


Psychological comorbidity is highly present in irritable bowel syndrome (IBS). Recent research points to a role of intestinal microbiota in visceral hypersensitivity, anxiety, and depression. Increased disease reactivity to psychological stress has been described too. A few clinical studies have attempted to identify features of dysbiosis in IBS. While animal studies revealed strong associations between stress and gut microbiota, studies in humans are rare. This review covers the most important studies on intestinal microbial correlates of psychological and clinical features in IBS, including stress, anxiety, and depression.

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