Skip to main content
main-content

Tipp

Weitere Artikel dieser Ausgabe durch Wischen aufrufen

01.11.2014 | Review | Ausgabe 21-22/2014

Wiener Medizinische Wochenschrift 21-22/2014

Interplay of drug metabolizing enzymes with cellular transporters

Zeitschrift:
Wiener Medizinische Wochenschrift > Ausgabe 21-22/2014
Autoren:
PhD Michaela Böhmdorfer, PhD Alexandra Maier-Salamon, Mpharm Juliane Riha, Mpharm Stefan Brenner, PhD Martina Höferl, Univ.-Prof. Dr. Walter Jäger

Summary

Many endogenous and xenobiotic substances and their metabolites are substrates for drug metabolizing enzymes and cellular transporters. These proteins may not only contribute to bioavailability of molecules but also to uptake into organs and, consequently, to overall elimination. The coordinated action of uptake transporters, metabolizing enzymes, and efflux pumps, therefore, is a precondition for detoxification and elimination of drugs. As the understanding of the underlying mechanisms is important to predict alterations in drug disposal, adverse drug reactions and, finally, drug–drug interactions, this review illustrates the interplay between selected uptake/efflux transporters and phase I/II metabolizing enzymes.

Bitte loggen Sie sich ein, um Zugang zu diesem Inhalt zu erhalten

Literatur
Über diesen Artikel

Weitere Artikel der Ausgabe 21-22/2014

Wiener Medizinische Wochenschrift 21-22/2014 Zur Ausgabe