nach oben

Erschienen in:

18.01.2022 | original article

Interleukin 10 rs1800896 and interleukin 1B rs16944 polymorphisms and the risk of cervical cancer

verfasst von: Jasenka Wagner, Sanela Štibi, Nikica Selak, Ilija Alvir, Ivica Mamić, Luka Marcelić, Lucija Šušnjar, Mario Puljiz, Marija Heffer, Damir Danolić

Erschienen in: Wiener Medizinische Wochenschrift | Ausgabe 3-4/2023

Einloggen, um Zugang zu erhalten

Summary

Background

The purpose of this study was to evaluate the relationships between interleukin 10 (IL10) (rs1800896) and interleukin 1B (IL1B) (rs16944) genetic polymorphisms and the risk for cervical cancer in a cohort of women from Croatia.

Methods

A case–control study of 81 patients with cervical cancer and 80 age-matched healthy controls was performed. We collected peripheral blood samples, extracted deoxiribonucleic acid (DNA), and analyzed two single-nucleotide polymorphisms (SNPs) rs1800896 and rs16944 using TaqMan assays (Fa. Thermo Fisher Scientific, Waltham, MA, USA) and real-time polymerase chain reaction (PCR). We investigated a possible association between two cytokine genetic polymorphisms and the occurrence of cervical cancer.

Results

Our results showed no significant difference in the frequency of IL10 (rs1800896) and IL1B (rs16944) genotypes between the patients and the controls (χ2 test, P < 0.05).

Conclusion

In this study, no association was found between IL10 rs1800896 and IL1B rs16944 polymorphisms and cervical cancer development.

Nächster Artikel Interleukin 10 rs1800896 and interleukin 1B rs16944 polymorphisms and cervical cancer: Correspondence

Walboomers JM, Jacobs MV, Manos MM, et al. Human papillomavirus is a necessary cause of invasive cervical cancer worldwide. J Pathol. 1999;189:12.CrossRefPubMed

Palefsky J. Human papillomavirus infection in HIV-infected persons. Top HIV Med. 2007;15:130–3.PubMed

Osiagwu DD, Azenabor AE, Osijirin AA, et al. Evaluation of interleukin 8 and interleukin 10 cytokines in liquid based cervical cytology samples. Pan Afr Med J. 2019;32:148.CrossRefPubMedPubMedCentral

Li B, Zhang L, Zhao J, et al. The value of cytokine levels in triage and risk prediction for women with persistent high-risk human papilloma virus infection of the cervix. Infect Agent Cancer. 2019;14:16.CrossRefPubMedPubMedCentral

Kabel AM. Relationship between cancer and cytokines. J Cancer Res Treat. 2014;2:41–3.

Xu Y, Zhu KJ, Zhu N, et al. Expression of Foxp3+CD4+CD25+ regulatory T cells and Th1/Th2, Tc1/Tc2 profiles in the peripheral blood of patients with condyloma acuminatum. Clin Exp Dermatol. 2009;34:229–35.CrossRefPubMed

Su D‑L, Lu Z‑M, Shen M‑N, et al. Roles of pro- and anti-inflammatory cytokines in the pathogenesis of SLE. Biomed Res Int. 2012; https://doi.org/10.1155/2012/347141.CrossRefPubMedPubMedCentral

Munoz N, Bosch FX, de Sanjose S, et al. Epidemiologic classification of human papillomavirus types associated with cervical cancer. N Engl J Med. 2003;348:518–27.CrossRefPubMed

Wang SS, Bratti MC, Rodriguez AC, et al. Common variants in immune and DNA repair genes and risk for human papillomavirus persistence and progression to cervical cancer. J Infect Dis. 2009;199:20–30.CrossRefPubMed

10.

Duan HX, Chen YY, Shi JZ, Ren NN, Li XJ. Association of IL‑6 -174G>C (rs1800795) polymorphism with cervical cancer susceptibility. Biosci Rep. 2018;38(5):BSR20181071.CrossRefPubMedPubMedCentral

11.

Wang L, Zhao W, Hong J, et al. Association between IL1B gene and cervical cancer susceptibility in Chinese Uygur population: a case-control study. Mol Genet Genomic Med. 2019;7:e779.CrossRefPubMedPubMedCentral

12.

Kwaśniak K, Czarnik-Kwaśniak J, Maziarz A, et al. Scientific reports concerning the impact of interleukin 4, interleukin 10 and transforming growth factor β on cancer cells. Cent Eur J Immunol. 2019;44:190–200.CrossRefPubMedPubMedCentral

13.

Berti FCB, Pereira APL, Cebinelli GCM, et al. The role of interleukin 10 in human papilloma virus infection and progression to cervical carcinoma. Cytokine Growth Factor Rev. 2017;34:1–13.CrossRefPubMed

14.

Du GH, Wang JK, Richards JR, et al. Genetic polymorphisms in tumor necrosis factor alpha and interleukin-10 are associated with an increased risk of cervical cancer. Int Immunopharmacol. 2019;66:154–61.CrossRefPubMed

15.

Wang B, Wang H, Li P, et al. Relationships of interleukin-10 with the regulatory T cell ratio and prognosis of cervical cancer patients. Clinics (Sao Paulo). 2018;73:e679.CrossRefPubMed

16.

Guo C, Wen L, Song JK, et al. Significant association between interleukin-10 gene polymorphisms and cervical cancer risk: a meta-analysis. Oncotarget. 2018;9:12365–75.CrossRefPubMedPubMedCentral

17.

Georgescu SR, Mitran CI, Mitran MI, et al. New insights in the pathogenesis of HPV infection and the associated carcinogenic processes: the role of chronic inflammation and oxidative stress. J Immunol Res. 2018; https://doi.org/10.1155/2018/5315816.CrossRefPubMedPubMedCentral

18.

Kemp TJ, Hildesheim A, Garcia-Pineres A, et al. Elevated systemic levels of inflammatory cytokines in older women with persistent cervical human papillomavirus infection. Cancer Epidemiol Biomarkers Prev. 2010;1:1954–9.CrossRef

19.

Kamangar F, Cheng C, Abnet CC, et al. Interleukin-1B polymorphisms and gastric cancer risk—a meta-analysis. Cancer Epidemiol Biomarkers Prev. 2006;15:1920–8.CrossRefPubMed

20.

El Omar EM, Carrington M, Chow WH, et al. Interleukin‑1 polymorphisms associated with increased risk of gastric cancer. Nature. 2000;404:398–402.CrossRefPubMed

21.

Xu H, Ding Q, Jiang HW. Genetic polymorphism of interleukin-1A (IL-1A), IL-1B, and IL‑1 receptor antagonist (IL-1RN) and prostate cancer risk. Asian Pac J Cancer Prev. 2014;15:8741–7.CrossRefPubMed

22.

Al-tahhan MA, Etewa RL, et al. Association between circulating interleukin‑1 beta (IL-1β) levels and IL-1β C‑511T polymorphism with cervical cancer risk in Egyptian women. Mol Cell Biochem. 2011;353:159–65.CrossRefPubMed

23.

Shi YY, He L. SHEsis, a powerful software platform for analyses of linkage disequilibrium, haplotype construction, and genetic association at polymorphism loci. Cell Res. 2005;15:97–8.CrossRefPubMed

24.

Solé X, Guinó E, Valls J, et al. SNPStats: a web tool for the analysis of association studies. Bioinformatics. 2006;22:1928–9.CrossRefPubMed

25.

Cruz-Gregorio A, Manzo-Merino J, Lizano M. Cellular redox, cancer and human papillomavirus. Virus Res. 2018;246:35–45.CrossRefPubMed

26.

Zoodsma M, Nolte IM, Schipper M, et al. Interleukin-10 and Fas polymorphisms and susceptibility for (pre) neoplastic cervical disease. Int J Gynecol Cancer. 2005;15(3):282–90.CrossRefPubMed

27.

Eskdale J, Kube D, Tesch H, et al. Mapping of the human IL10 gene and further characterization of the 5’ flanking sequence. Immunogenetics. 1997;46:120–8.CrossRefPubMed

28.

Kingo K, Ratsep R, Koks S, et al. Influence of genetic polymorphisms on interleukin-10 mRNA expression and psoriasis susceptibility. J Dermatol Sci. 2005;37:111–3.CrossRefPubMed

29.

Zhou H, Liu A, Zhou B, et al. Interleukin-10 gene rs1800896 polymorphism increases risk of acute pancreatitis. Medicine. 2017;96:e9006.CrossRefPubMedPubMedCentral

30.

Chen H, Tang J, Shen N, et al. Interleukin 10 gene rs1800896 polymorphism is associated with the risk of prostate cancer. Oncotarget. 2017;8(39):66204–14.CrossRefPubMedPubMedCentral

31.

Cao LN, Cheng SL, Liu W. IL10 rs1800896 polymorphism is associated with liver cirrhosis and chronic hepatitis B. Genet Mol Res. 2016;22:15.

32.

Singhal P, Kumar A, Bharadwaj S, et al. Association of IL-10 GTC haplotype with serum level and HPV infection in the development of cervical carcinoma. Tumour Biol. 2015;36:2287–98.CrossRefPubMed

33.

Bai CY, Shi XY, He J, et al. Association between IL-10 genetic variations and cervical cancer susceptibility in a Chinese population. Genet Mol Res. 2016;5:15.

34.

Torres-Poveda K, Burguete-García AI, Cruz M, et al. The SNP at −592 of human IL-10 gene is associated with serum IL-10 levels and increased risk for human papillomavirus cervical lesion development. Infect Agent Cancer. 2012;7:32.CrossRefPubMedPubMedCentral

35.

Zidi S, Gazouani E, Stayoussef M, et al. IL-10 gene promoter and intron polymorphisms as genetic biomarkers of cervical cancer susceptibility among Tunisians. Cytokine. 2015;76:343–7.CrossRefPubMed

36.

Xu J, Yin Z, Cao S, et al. Systematic review and meta-analysis on the association between IL-1B polymorphisms and cancer risk. PLoS One. 2013;8:e63654.CrossRefPubMedPubMedCentral

37.

Kang S, Kim JW, Park NH, et al. Interleukin‑1 beta-511 polymorphism and risk of cervical cancer. J Korean Med Sci. 2007;22:110–3.CrossRefPubMedPubMedCentral

38.

Qian N, Chen X, Han S, et al. Circulating IL-1beta levels, polymorphisms of IL-1B, and risk of cervical cancer in Chinese women. J Cancer Res Clin Oncol. 2010;136:709–16.CrossRefPubMed

Titel: Interleukin 10 rs1800896 and interleukin 1B rs16944 polymorphisms and the risk of cervical cancer
verfasst von: Jasenka Wagner
Sanela Štibi
Nikica Selak
Ilija Alvir
Ivica Mamić
Luka Marcelić
Lucija Šušnjar
Mario Puljiz
Marija Heffer
Damir Danolić
Publikationsdatum: 18.01.2022
Verlag: Springer Vienna
Erschienen in: Wiener Medizinische Wochenschrift / Ausgabe 3-4/2023
Print ISSN: 0043-5341
Elektronische ISSN: 1563-258X
DOI: https://doi.org/10.1007/s10354-021-00907-w

Springer Medizin Österreich

Summary

Background

Methods

Results

Conclusion

Bitte loggen Sie sich ein, um Zugang zu diesem Inhalt zu erhalten

Weitere Artikel der Ausgabe 3-4/2023

Ovarian yolk sac tumor in a premenarchal girl

Aktuelle Aspekte zur Ernährung bei Hypercholesterinämie

Sudden death of a pregnant woman because of massive aspiration—case report and review of literature

Perimortem Caesarean section because of a live fetus: case report and literature review

Interleukin 10 rs1800896 and interleukin 1B rs16944 polymorphisms and cervical cancer: Correspondence

Sarcopenia—a geriatric pandemic