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29.04.2019 | original article | Ausgabe 1/2020

Spektrum der Augenheilkunde 1/2020

Influence of optic media of the human eye on the imaging of Argus® II retinal prosthesis with intraoperative spectral-domain optical coherence tomography

Spektrum der Augenheilkunde > Ausgabe 1/2020
MD, PhD Lyubomyr M. Lytvynchuk, MD Christiane I. Falkner-Radler, MD, PhD Andrzej Grzybowski, MD Carl G. Glittenberg, MD Farnusch Shams-Mafi, MD Siamak Ansari-Shahrezaei, MD Susanne Binder
Wichtige Hinweise

Electronic supplementary material

The online version of this article (https://​doi.​org/​10.​1007/​s00717-019-0429-x) contains a video in the supplementary material, which is available to authorized users.
LL and SB designed the study, carried out the data collection, participated in the surgery, did intraoperative and postoperative iSD-OCT data analysis, and drafted the manuscript. CG, CF, and FS carried out data collection and postoperative iSD-OCT data post-processing and analysis, and helped to draft the manuscript. SAS participated in study design and coordination, did preoperative iSD-OCT data analysis, and helped to draft the manuscript. LL, SAS, and SB generated the idea and aim of the study, performed the surgery and intraoperative iSD-OCT examination, corrected the manuscript. LL, AG and SB summarise the data and wrote the final version of the manuscript. All authors read and approved the final manuscript.

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This study aimed to evaluate the influence of the optic media of the human eye on intraoperative spectral-domain optical coherence tomography (iSD-OCT) of an Argus® II retinal prosthesis (AIIRP) during its implantation.


One AIIRP was implanted in a human eye with end-stage retinitis pigmentosa and another one in a test eye. Intraoperative imaging was performed using the Rescan™ 700, a microscope-integrated iSD-OCT system. The feasibility of iSD-OCT imaging for AIIRP implantation was assessed during different surgical steps. Data were post-processed postoperatively using the ImageJ graphic software.


The quality of imaging of the AIIRP during its implantation was good and almost the same in the human eye and in the training eye. The histograms showed that the optic media had no impact on the quality of iSD-OCT scans, as the difference between the pixel values was not statistically significant. Additionally, the quality of iSD-OCT imaging of the retina under the AIIRP array was not decreased by the array itself.


The iSD-OCT-assisted surgical approach facilitates imaging of the AIIRP during its implantation. Uncompromised human optic media do not reduce the quality of AIIRP array imaging throughout all the surgical steps. The influence of the opaque cornea in long-lasting surgeries on the iSD-OCT scan quality during AIIRP implantation has to be investigated.

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