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08.08.2017 | original article | Ausgabe 4/2017

neuropsychiatrie 4/2017

Influence of intravenous administration of the antipsychotic drug benperidol on the QT interval

Zeitschrift:
neuropsychiatrie > Ausgabe 4/2017
Autoren:
Alexander Schmidt, Peter Fischer, Beate Wally, Joachim Scharfetter

Summary

A group effect is generally assumed regarding the prolongation of the QT interval through butyrophenone antipsychotics like haloperidol. Consequently intravenous administration of benperidol is seen critically notwithstanding sparse evidence; thus benperidol and haloperidol were compared regarding their cardiac risk of prolonging the QT interval when administered intravenously for acute sedation of psychotic patients. The QT interval was measured by a 12-lead ECG. For the correction of QT values Bazett’s formula was used. The resulting QTc intervals of the benperidol and the haloperidol group were compared using Mann–Whitney U-test. Our data provide statistical evidence for benperidol being less prone to cause QTc prolongation than haloperidol (p = 0.049). The results of our study indicate a more favourable risk profile of benperidol compared to haloperidol regarding QTc prolongation when administered intravenously.

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