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Erschienen in: Wiener klinische Wochenschrift 11-12/2018

29.05.2018 | original article

Increased intermediate monocyte fraction in peripheral blood is associated with nonalcoholic fatty liver disease

verfasst von: Jianmei Zhang, Wenbin Chen, Li Fang, Qiu Li, Xu Zhang, Haiqing Zhang, Qingbo Guan, Rang Zhao, Chongbo Yang, Fei Jing

Erschienen in: Wiener klinische Wochenschrift | Ausgabe 11-12/2018

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Summary

Nonalcoholic fatty liver disease (NAFLD) currently represents the most common hepatic disease worldwide and is closely linked to cardiovascular disease, obesity and diabetes mellitus. This study aimed to investigate NAFLD and its influence on different monocyte subpopulations to determine the presence of significant associations. A total of 3 monocyte subpopulations were investigated, i.e. classical (CD14++CD16−), intermediate (CD14++CD16+) and non-classical (CD14+CD16++). Of the participants 261 were included in this study (n = 53 with NAFLD, n = 208 controls). Ultrasonography was used to diagnose NAFLD and exclude other morphologic causes of liver diseases and other tests (including medical history inquiries and detection of hepatitis virus) were performed to exclude other causes of parenchymal liver disease. Classical inflammatory and metabolic-related NAFLD biomarkers were also determined. In contrast to the healthy control group, the intermediate monocyte fraction was increased in NAFLD patients (p = 0.032), while the classical monocyte fraction was decreased (p = 0.025). Intermediate monocyte fraction, body mass index (BMI) and tumor necrosis factor alpha (TNF-α) were independent risk factors for NAFLD. Classical, non-classical and intermediate monocytes fraction were strongly associated with age, triglyceride, and waist circumference. This study suggests that the intermediate monocyte fraction in peripheral blood is likely related to the aggravation of NAFLD.
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Metadaten
Titel
Increased intermediate monocyte fraction in peripheral blood is associated with nonalcoholic fatty liver disease
verfasst von
Jianmei Zhang
Wenbin Chen
Li Fang
Qiu Li
Xu Zhang
Haiqing Zhang
Qingbo Guan
Rang Zhao
Chongbo Yang
Fei Jing
Publikationsdatum
29.05.2018
Verlag
Springer Vienna
Erschienen in
Wiener klinische Wochenschrift / Ausgabe 11-12/2018
Print ISSN: 0043-5325
Elektronische ISSN: 1613-7671
DOI
https://doi.org/10.1007/s00508-018-1348-6

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