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Erschienen in: Wiener klinische Wochenschrift 23-24/2020

20.07.2020 | original article

Impella in cardiogenic shock following acute myocardial infarction: a systematic review and meta-analysis

verfasst von: MD, MHSc, MSc Kris G. Vargas, MD Bernhard Jäger, MD Christoph C. Kaufmann, MD Andrea Biagioli, MD Stephan Watremez, MD Fernando Gatto, MD Cem Özbek, MD Amjad Razouk, MD Alexander Geppert, MD Prof. Dr. Kurt Huber

Erschienen in: Wiener klinische Wochenschrift | Ausgabe 23-24/2020

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Summary

Background and objective

Cardiogenic shock (CS) conveys a high mortality risk. A cardiac assist device may serve as bridge to patient recovery. We aimed to provide a pooled estimate on mortality and complications from studies evaluating the use of the left ventricular assist device Impella in CS following acute myocardial infarction. In addition, we evaluated whether mortality risk differed with device placement before or after percutaneous coronary intervention (PCI).

Methods

We searched Medline, Embase and Web of Science from 2005 until July 2019 for observational studies or clinical trials on this specific patient group. Studies were required to report on 30-day all-cause mortality and device-related complications. We calculated pooled proportions with 95% confidence intervals (CI) using random effects models and the inverse variance method.

Results

Overall, 671 patients from 11 studies (2 randomized and 9 observational) were included. Pooled proportions showed a 30-day mortality of 54.6% (95% CI 47.3–61.8; P = 0.22; I2 = 65.8%). Among complications, major bleeding was found in 19.9% (95% CI 14.2–27.3; P < 0.05; I2 = 69.1%), hemolysis in 10.5% (95% CI 7.2–15.0; P < 0.05; I2 = 52.1%), limb ischemia in 5.0% (95% CI 2.6–9.5; P < 0.05; I2 = 48.3%) and stroke in 3.8% of patients (95% CI 2.4–5.9; P < 0.05; I2 = 0%). Sensitivity analysis demonstrated a statistically significant risk reduction in 30-day mortality when Impella was implanted prior to PCI as compared to after PCI, risk ratio (RR): 0.71, CI 0.58–0.86, P = 0.001, I2 = 0%.

Conclusion

Pooled estimates of Impella use in myocardial infarction with CS revealed a high 30-day mortality; however, as compared to post-PCI, Impella initiation prior to PCI was associated with a survival benefit.
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Metadaten
Titel
Impella in cardiogenic shock following acute myocardial infarction: a systematic review and meta-analysis
verfasst von
MD, MHSc, MSc Kris G. Vargas
MD Bernhard Jäger
MD Christoph C. Kaufmann
MD Andrea Biagioli
MD Stephan Watremez
MD Fernando Gatto
MD Cem Özbek
MD Amjad Razouk
MD Alexander Geppert
MD Prof. Dr. Kurt Huber
Publikationsdatum
20.07.2020
Verlag
Springer Vienna
Erschienen in
Wiener klinische Wochenschrift / Ausgabe 23-24/2020
Print ISSN: 0043-5325
Elektronische ISSN: 1613-7671
DOI
https://doi.org/10.1007/s00508-020-01712-y