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Erschienen in: Wiener klinische Wochenschrift 3-4/2021

28.11.2019 | original article

Impact of hemodialysis on liver stiffness measured with real-time two-dimensional shear wave elastography

verfasst von: Danijela Zjacic Puljiz, Antonio Mestrovic, Ivan Zaja, MD, PhD Ante Tonkic, Ivica Grgurevic, Darko Duplancic, Ivana Kristina Delic Jukic, Dragan Ljutic, Zeljko Puljiz

Erschienen in: Wiener klinische Wochenschrift | Ausgabe 3-4/2021

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Summary

Background and aims

The impact of hemodialysis on liver stiffness is still unclear. The aim of the study was to assess liver fibrosis by real-time two-dimensional shear wave elastography (RT 2D-SWE) and to quantify the influence of net fluid withdrawal on liver stiffness during one hemodialysis session. The second aim was to investigate the influence of systolic blood pressure and time spent on dialysis (in years) on liver stiffness measurements.

Methods

This before/after hemodialysis (HD) study in a group of end stage renal disease (ESRD) patients was carried out with patients on regular HD. Measurements of liver stiffness were done using RT 2D-SWE directly before and after a hemodialysis session.

Results

In this study 27 patients with mean age 69.4 ± 14.75 years were included. Mean net fluid withdrawal volume per session was 2874.07 ± 778.35 ml. Mean pre-HD and post-HD liver stiffness measurements were 8.15 kPa (95% confidence interval, CI 7.61–8.68) and 6.70 kPa (95% CI 6.10–7.30 kPa), respectively. Mean liver stiffness reduction was 1.448 ± 1.14 kPa. The amount of fluid removed correlated with the decline in liver stiffness values after HD (ρ = 0.523, P = 0.003). There was a positive but statistically not significant correlation between time spent in HD and liver stiffness (ρ = 0.151, P = 0.623)

Conclusion

Liver stiffness significantly declined after one session of HD. The change in liver stiffness was strongly correlated with the amount of net fluid withdrawal. Random liver stiffness measurements (LSM) by RT 2D-SWE does not precisely show the degree of fibrosis, Furthermore, it is presumed that postdialysis liver stiffness values likely reflect the real degree of liver fibrosis.

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Metadaten
Titel
Impact of hemodialysis on liver stiffness measured with real-time two-dimensional shear wave elastography
verfasst von
Danijela Zjacic Puljiz
Antonio Mestrovic
Ivan Zaja
MD, PhD Ante Tonkic
Ivica Grgurevic
Darko Duplancic
Ivana Kristina Delic Jukic
Dragan Ljutic
Zeljko Puljiz
Publikationsdatum
28.11.2019
Verlag
Springer Vienna
Erschienen in
Wiener klinische Wochenschrift / Ausgabe 3-4/2021
Print ISSN: 0043-5325
Elektronische ISSN: 1613-7671
DOI
https://doi.org/10.1007/s00508-019-01577-w