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Erschienen in: Wiener klinische Wochenschrift 19-20/2015

01.10.2015 | original article

Impact of elevated serum estradiol/free testosterone ratio on male varicose veins in a prospective study

verfasst von: Ass. Prof. Sedat Özcan, MD, Dolunay Odabasi, Tolga Kurt, Ali Kemal Gür, Aysegul Kunt, Yavuz Balaharoglu, Alper Sami Kunt

Erschienen in: Wiener klinische Wochenschrift | Ausgabe 19-20/2015

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Summary

Objective

Although some studies indicate an association between increased levels of estradiol and varicose veins in women, the role of sex hormones on varicose veins have a question mark in men.

Methods

We investigated estradiol-2/free testosterone (E2/fT) ratio relationship on varicosity in 100 male patients dividing them into two groups. Group A (n = 46) had varicose veins with endocrinological problems, especially infertility, whereas group B (n = 54) also had varicose veins but no endocrinological problems. Venous blood samples were drawn from both groups in the morning to detect the levels of serum estradiol (E2), androstenedione, dehydroepiandrostenedione sulphate and free testosterone (fT). Patient history, physical examination, colour duplex ultrasound of both limbs and classification of CEAP were performed in both groups. Serum E2/fT ratio was calculated in correspondence with CEAP classification. CEAP classification is the varicosity classification, and it is concerned about the clinical class (C), etiology (E), anatomical distribution (A) and underlying pathophysiology (P).

Results

E2/fT ratio was significantly higher in group A (4.18 ± 0.54) compared with group B (2.98 ± 0.36). Moreover, there is a high correlation between serum E2/fT ratio and CEAP clinical classification in group A (4) compared with group B (2).

Conclusion

Serum E2/fT ratio is associated with varicose veins in male patients.
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Metadaten
Titel
Impact of elevated serum estradiol/free testosterone ratio on male varicose veins in a prospective study
verfasst von
Ass. Prof. Sedat Özcan, MD
Dolunay Odabasi
Tolga Kurt
Ali Kemal Gür
Aysegul Kunt
Yavuz Balaharoglu
Alper Sami Kunt
Publikationsdatum
01.10.2015
Verlag
Springer Vienna
Erschienen in
Wiener klinische Wochenschrift / Ausgabe 19-20/2015
Print ISSN: 0043-5325
Elektronische ISSN: 1613-7671
DOI
https://doi.org/10.1007/s00508-014-0652-z

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