nach oben

Tipp

Hidradenitis suppurativa

verfasst von: Dr. Antonia Wiala, Theresa Stockinger, Christian Posch, Klemens Rappersberger

Erschienen in: hautnah | Ausgabe 3/2022

Einloggen, um Zugang zu erhalten

Zusammenfassung

Die Hidradenitis suppurativa (HS, Acne inversa) ist eine chronisch entzündliche Hauterkrankung, gekennzeichnet durch das rezidivierende Auftreten von entzündlichen Knoten, Abszessen und Fisteln in den intertriginösen Arealen. Schmerzen und putride übelriechende Sekretion führen zu massiven Einschränkungen der Lebensqualität. Die follikuläre Okklusion scheint in der multifaktoriellen Pathogenese der Erkrankung eine wichtige Rolle zu spielen. Zudem sind genetische Prädispositionen und zahlreiche Triggerfaktoren wie Übergewicht und Tabakkonsum bekannt. Die Diagnose der HS wird klinisch anhand der charakteristischen Hautveränderungen gestellt. Zur Einteilung der Schweregrade dient unter anderem das Hurley-Staging. Therapeutische Optionen bei milder HS umfassen eine antiseptische sowie antibiotische Lokaltherapie. Bei milder bis moderater Erkrankung kann durch systemische antibiotische Therapien (Kombination Clindamycin-Rifampicin; Tetracycline) eine vorrübergehende Remission erreicht werden. Zur Behandlung der moderaten bis schweren HS ist Adalimumab, ein TNF-α-Antagonist, zugelassen. Operative Techniken spielen eine wichtige Rolle bei der Behandlung von Fistelgängen und Narbensträngen. Mittels En-bloc-Resektion, also der großzügigen Exzision erkrankter Hautareale, kann die Heilung eines umschriebenen Areals erreicht werden. Hauptziel aktueller Therapien bleibt eine verbesserte Lebensqualität.

Vorheriger Artikel Simpler Farbtest für extragenitalen Lichen sclerosus

Nächster Artikel Mastozytose

Saunte DML, Jemec GBE (2017) Hidradenitis suppurativa: advances in diagnosis and treatment. JAMA 318:2019–2032 PubMedCrossRef

Revuz JE, Canoui-Poitrine F, Wolkenstein P, Viallette C, Gabison G, Pouget F, Poli F, Faye O, Roujeau JC, Bonnelye G, Grob JJ, Bastuji-Garin S (2008) Prevalence and factors associated with hidradenitis suppurativa: results from two case-control studies. J Am Acad Dermatol 59:596–601 PubMedCrossRef

Jemec GB, Heidenheim M, Nielsen NH (1996) The prevalence of hidradenitis suppurativa and its potential precursor lesions. J Am Acad Dermatol 35:191–194 PubMedCrossRef

Vaiopoulos AG, Nikolakis G, Zouboulis CC (2020) Hidradenitis suppurativa in paediatric patients: a retrospective monocentric study in Germany and review of the literature. J Eur Acad Dermatol Venereol 34:2140–2146 PubMedCrossRef

Tilles G (2006) Verneuil and Verneuil’s disease: an historical overview. In: Jemec GBE, Revuz J, Leyden JJ (Hrsg) Hidradenitis suppurativa. Springer, Berlin, Heidelberg, S 4–10 CrossRef

Pink A, Anzengruber F, Navarini AA (2018) Acne and hidradenitis suppurativa. Br J Dermatol 178:619–631 PubMedCrossRef

Yu CC, Cook MG (1990) Hidradenitis suppurativa: a disease of follicular epithelium, rather than apocrine glands. Br J Dermatol 122:763–769 PubMedCrossRef

van der Zee HH, de Ruiter L, van den Broecke DG, Dik WA, Laman JD, Prens EP (2011) Elevated levels of tumour necrosis factor (TNF)-alpha, interleukin (IL)-1beta and IL-10 in hidradenitis suppurativa skin: a rationale for targeting TNF-alpha and IL-1beta. Br J Dermatol 164:1292–1298 PubMedCrossRef

Sabat R, Grutz G, Warszawska K, Kirsch S, Witte E, Wolk K, Geginat J (2010) Biology of interleukin-10. Cytokine Growth Factor Rev 21:331–344 PubMedCrossRef

10.

Wolk K, Warszawska K, Hoeflich C, Witte E, Schneider-Burrus S, Witte K, Kunz S, Buss A, Roewert HJ, Krause M, Lukowsky A, Volk HD, Sterry W, Sabat R (2011) Deficiency of IL-22 contributes to a chronic inflammatory disease: pathogenetic mechanisms in acne inversa. J Immunol 186:1228–1239 PubMedCrossRef

11.

Jimenez-Gallo D, de la Varga-Martinez R, Ossorio-Garcia L, Albarran-Planelles C, Rodriguez C, Linares-Barrios M (2017) The clinical significance of increased serum proinflammatory cytokines, C‑reactive protein, and erythrocyte sedimentation rate in patients with hidradenitis suppurativa. Mediators Inflamm 2017:2450401 PubMedPubMedCentralCrossRef

12.

Ingram JR (2016) The genetics of hidradenitis suppurativa. Dermatol Clin 34:23–28 PubMedCrossRef

13.

von der Werth JM, Williams HC (2000) The natural history of hidradenitis suppurativa. J Eur Acad Dermatol Venereol 14:389–392 PubMedCrossRef

14.

Wang B, Yang W, Wen W, Sun J, Su B, Liu B, Ma D, Lv D, Wen Y, Qu T, Chen M, Sun M, Shen Y, Zhang X (2010) Gamma-secretase gene mutations in familial acne inversa. Science 330:1065 PubMedCrossRef

15.

Frew JW, Vekic DA, Woods J, Cains GD (2017) A systematic review and critical evaluation of reported pathogenic sequence variants in hidradenitis suppurativa. Br J Dermatol 177:987–998 PubMedCrossRef

16.

Wang Z, Yan Y, Wang B (2021) Gamma-secretase genetics of hidradenitis suppurativa: a systematic literature review. Dermatology 237:698–704 PubMedCrossRef

17.

Canoui-Poitrine F, Le Thuaut A, Revuz JE, Viallette C, Gabison G, Poli F, Pouget F, Wolkenstein P, Bastuji-Garin S (2013) Identification of three hidradenitis suppurativa phenotypes: latent class analysis of a cross-sectional study. J Invest Dermatol 133:1506–1511 PubMedCrossRef

18.

Ingram JR, Wood M, John B, Butler R, Anstey AV (2013) Absence of pathogenic gamma-secretase mutations in a South Wales cohort of familial and sporadic hidradenitis suppurativa (acne inversa). Br J Dermatol 168:874–876 PubMedCrossRef

19.

Nikolakis G, Kaleta KP, Vaiopoulos AG, Wolter K, Baroud S, Wojas-Pelc A, Zouboulis CC (2021) Phenotypes and pathophysiology of syndromic hidradenitis suppurativa: different faces of the same disease? A systematic review. Dermatology 237:673–697 PubMedCrossRef

20.

Guet-Revillet H, Jais JP, Ungeheuer MN, Coignard-Biehler H, Duchatelet S, Delage M, Lam T, Hovnanian A, Lortholary O, Nassif X, Nassif A, Join-Lambert O (2017) The microbiological landscape of anaerobic infections in hidradenitis suppurativa: a prospective metagenomic study. Clin Infect Dis 65:282–291 PubMedCrossRef

21.

Nikolakis G, Join-Lambert O, Karagiannidis I, Guet-Revillet H, Zouboulis CC, Nassif A (2015) Bacteriology of hidradenitis suppurativa/acne inversa: a review. J Am Acad Dermatol 73:S12–8 PubMedCrossRef

22.

Ring HC, Bay L, Nilsson M, Kallenbach K, Miller IM, Saunte DM, Bjarnsholt T, Tolker-Nielsen T, Jemec GB (2017) Bacterial biofilm in chronic lesions of hidradenitis suppurativa. Br J Dermatol 176:993–1000 PubMedCrossRef

23.

Konig A, Lehmann C, Rompel R, Happle R (1999) Cigarette smoking as a triggering factor of hidradenitis suppurativa. Dermatology 198:261–264 PubMedCrossRef

24.

Hana A, Booken D, Henrich C, Gratchev A, Maas-Szabowski N, Goerdt S, Kurzen H (2007) Functional significance of non-neuronal acetylcholine in skin epithelia. Life Sci 80:2214–2220 PubMedCrossRef

25.

Wittebole X, Hahm S, Coyle SM, Kumar A, Calvano SE, Lowry SF (2007) Nicotine exposure alters in vivo human responses to endotoxin. Clin Exp Immunol 147:28–34 PubMedPubMedCentralCrossRef

26.

Wolk K, Join-Lambert O, Sabat R (2020) Aetiology and pathogenesis of hidradenitis suppurativa. Br J Dermatol 183:999–1010 PubMedCrossRef

27.

Karagiannidis I, Nikolakis G, Zouboulis CC (2016) Endocrinologic aspects of hidradenitis suppurativa. Dermatol Clin 34:45–49 PubMedCrossRef

28.

Vossen AR, van Straalen KR, Prens EP, van der Zee HH (2017) Menses and pregnancy affect symptoms in hidradenitis suppurativa: a cross-sectional study. J Am Acad Dermatol 76:155–156 PubMedCrossRef

29.

Lyons AB, Peacock A, McKenzie SA, Jacobsen G, Naik HB, Shi VY, Hamzavi IH, Hsiao JL (2020) Evaluation of hidradenitis suppurativa disease course during pregnancy and postpartum. JAMA Dermatol 156:681–685 PubMedCrossRef

30.

Garg A, Neuren E, Strunk A (2018) Hidradenitis suppurativa is associated with polycystic ovary syndrome: a population-based analysis in the United States. J Invest Dermatol 138:1288–1292 PubMedCrossRef

31.

Schrader AM, Deckers IE, van der Zee HH, Boer J, Prens EP (2014) Hidradenitis suppurativa: a retrospective study of 846 Dutch patients to identify factors associated with disease severity. J Am Acad Dermatol 71:460–467 PubMedCrossRef

32.

Boer J (2017) Should hidradenitis suppurativa be included in dermatoses showing koebnerization? Is it friction or fiction? Dermatology 233:47–52 PubMedCrossRef

33.

Attanoos RL, Appleton MA, Douglas-Jones AG (1995) The pathogenesis of hidradenitis suppurativa: a closer look at apocrine and apoeccrine glands. Br J Dermatol 133:254–258 PubMedCrossRef

34.

Jemec GB, Kimball AB (2015) Hidradenitis suppurativa: epidemiology and scope of the problem. J Am Acad Dermatol 73:S4–7 PubMedCrossRef

35.

Ovadja ZN, Schuit MM, van der Horst C, Lapid O (2019) Inter- and intrarater reliability of Hurley staging for hidradenitis suppurativa. Br J Dermatol 181:344–349 PubMedPubMedCentralCrossRef

36.

Sartorius K, Emtestam L, Jemec GB, Lapins J (2009) Objective scoring of hidradenitis suppurativa reflecting the role of tobacco smoking and obesity. Br J Dermatol 161:831–839 PubMedCrossRef

37.

Kimball AB, Kerdel F, Adams D, Mrowietz U, Gelfand JM, Gniadecki R, Prens EP, Schlessinger J, Zouboulis CC, van der Zee HH, Rosenfeld M, Mulani P, Gu Y, Paulson S, Okun M, Jemec GB (2012) Adalimumab for the treatment of moderate to severe hidradenitis suppurativa: a parallel randomized trial. Ann Intern Med 157:846–855 PubMedCrossRef

38.

Zouboulis CC, Tzellos T, Kyrgidis A, Jemec GBE, Bechara FG, Giamarellos-Bourboulis EJ, Ingram JR, Kanni T, Karagiannidis I, Martorell A, Matusiak L, Pinter A, Prens EP, Presser D, Schneider-Burrus S, von Stebut E, Szepietowski JC, van der Zee HH, Wilden SM, Sabat R, European Hidradenitis Suppurativa Foundation Investigator Group (2017) Development and validation of the international hidradenitis suppurativa severity score system (IHS4), a novel dynamic scoring system to assess HS severity. Br J Dermatol 177:1401–1409 PubMedCrossRef

39.

Shlyankevich J, Chen AJ, Kim GE, Kimball AB (2014) Hidradenitis suppurativa is a systemic disease with substantial comorbidity burden: a chart-verified case-control analysis. J Am Acad Dermatol 71:1144–1150 PubMedCrossRef

40.

Sabat R, Chanwangpong A, Schneider-Burrus S, Metternich D, Kokolakis G, Kurek A, Philipp S, Uribe D, Wolk K, Sterry W (2012) Increased prevalence of metabolic syndrome in patients with acne inversa. PLoS One 7:e31810 PubMedPubMedCentralCrossRef

41.

Gold DA, Reeder VJ, Mahan MG, Hamzavi IH (2014) The prevalence of metabolic syndrome in patients with hidradenitis suppurativa. J Am Acad Dermatol 70:699–703 PubMedCrossRef

42.

Egeberg A, Gislason GH, Hansen PR (2016) Risk of major adverse cardiovascular events and all-cause mortality in patients with hidradenitis suppurativa. JAMA Dermatol 152:429–434 PubMedCrossRef

43.

Schneider-Burrus S, Witte-Haendel E, Christou D, Rigoni B, Sabat R, Diederichs G (2016) High prevalence of back pain and axial spondyloarthropathy in patients with hidradenitis suppurativa. Dermatology 232:606–612 PubMedCrossRef

44.

Richette P, Molto A, Viguier M, Dawidowicz K, Hayem G, Nassif A, Wendling D, Aubin F, Liote F, Bachelez H (2014) Hidradenitis suppurativa associated with spondyloarthritis—results from a multicenter national prospective study. J Rheumatol 41:490–494 PubMedCrossRef

45.

Deckers IE, Benhadou F, Koldijk MJ, Del Marmol V, Horvath B, Boer J, van der Zee HH, Prens EP (2017) Inflammatory bowel disease is associated with hidradenitis suppurativa: results from a multicenter cross-sectional study. J Am Acad Dermatol 76:49–53 PubMedCrossRef

46.

van der Zee HH, de Winter K, van der Woude CJ, Prens EP (2014) The prevalence of hidradenitis suppurativa in 1093 patients with inflammatory bowel disease. Br J Dermatol 171:673–675 PubMedCrossRef

47.

Frings VG, Bauer B, Gloditzsch M, Goebeler M, Presser D (2019) Assessing the psychological burden of patients with hidradenitis suppurativa. Eur J Dermatol 29:294–301 PubMed

48.

Sampogna F, Fania L, Mastroeni S, Fusari R, Napolitano M, Ciccone D, Mazzanti C, Pallotta S, Panebianco A, Abeni D (2020) Correlation between depression, quality of life and clinical severity in patients with hidradenitis suppurativa. Acta Derm Venereol 100:adv319 PubMedCrossRef

49.

Patel KR, Lee HH, Rastogi S, Vakharia PP, Hua T, Chhiba K, Singam V, Silverberg JI (2020) Association between hidradenitis suppurativa, depression, anxiety, and suicidality: a systematic review and meta-analysis. J Am Acad Dermatol 83:737–744 PubMedCrossRef

50.

Cugno M, Borghi A, Marzano AV (2017) PAPA, PASH and PAPASH syndromes: pathophysiology, presentation and treatment. Am J Clin Dermatol 18:555–562 PubMedCrossRef

51.

Hessam S, Sand M, Gambichler T, Bechara FG (2015) Correlation of inflammatory serum markers with disease severity in patients with hidradenitis suppurativa (HS). J Am Acad Dermatol 73:998–1005 PubMedCrossRef

52.

Wortsman X, Moreno C, Soto R, Arellano J, Pezo C, Wortsman J (2013) Ultrasound in-depth characterization and staging of hidradenitis suppurativa. Dermatol Surg 39:1835–1842 PubMedCrossRef

53.

Virgilio E, Bocchetti T, Balducci G (2015) Utility of MRI in the diagnosis and post-treatment evaluation of anogenital hidradenitis suppurativa. Dermatol Surg 41:865–866 PubMedCrossRef

54.

von der Werth JM, Jemec GB (2001) Morbidity in patients with hidradenitis suppurativa. Br J Dermatol 144:809–813 PubMedCrossRef

55.

Matusiak L, Bieniek A, Szepietowski JC (2010) Psychophysical aspects of hidradenitis suppurativa. Acta Derm Venereol 90:264–268 PubMedCrossRef

56.

Matusiak L, Szczech J, Kaaz K, Lelonek E, Szepietowski JC (2018) Clinical characteristics of pruritus and pain in patients with hidradenitis suppurativa. Acta Derm Venereol 98:191–194 PubMedCrossRef

57.

Cuenca-Barrales C, Montero-Vilchez T, Szepietowski JC, Matusiak L, Molina-Leyva A (2021) Sexual impairment in patients with hidradenitis suppurativa: a systematic review. J Eur Acad Dermatol Venereol 35:345–352 PubMedCrossRef

58.

Janse IC, Deckers IE, van der Maten AD, Evers AWM, Boer J, van der Zee HH, Prens EP, Horvath B (2017) Sexual health and quality of life are impaired in hidradenitis suppurativa: a multicentre cross-sectional study. Br J Dermatol 176:1042–1047 PubMedCrossRef

59.

Theut Riis P, Thorlacius L, Knudsen List E, Jemec GBE (2017) A pilot study of unemployment in patients with hidradenitis suppurativa in Denmark. Br J Dermatol 176:1083–1085 PubMedCrossRef

60.

Matusiak L, Bieniek A, Szepietowski JC (2010) Hidradenitis suppurativa markedly decreases quality of life and professional activity. J Am Acad Dermatol 62:706–708 PubMedCrossRef

61.

Wortsman X (2016) Imaging of hidradenitis suppurativa. Dermatol Clin 34:59–68 PubMedCrossRef

62.

Micieli R, Alavi A (2018) Lymphedema in patients with hidradenitis suppurativa: a systematic review of published literature. Int J Dermatol 57:1471–1480 PubMedCrossRef

63.

Deckers IE, van der Zee HH, Prens EP (2016) Severe fatigue based on anaemia in patients with hidradenitis suppurativa: report of two cases and a review of the literature. J Eur Acad Dermatol Venereol 30:174–175 PubMedCrossRef

64.

Tannenbaum R, Strunk A, Garg A (2019) Association between hidradenitis suppurativa and lymphoma. JAMA Dermatol 155:624–625 PubMedPubMedCentralCrossRef

65.

Chapman S, Delgadillo D III, Barber C, Khachemoune A (2018) Cutaneous squamous cell carcinoma complicating hidradenitis suppurativa: a review of the prevalence, pathogenesis, and treatment of this dreaded complication. Acta Dermatovenerol Alp Pannonica Adriat 27:25–28 PubMed

66.

Zouboulis CC, Desai N, Emtestam L, Hunger RE, Ioannides D, Juhasz I, Lapins J, Matusiak L, Prens EP, Revuz J, Schneider-Burrus S, Szepietowski JC, van der Zee HH, Jemec GB (2015) European S1 guideline for the treatment of hidradenitis suppurativa/acne inversa. J Eur Acad Dermatol Venereol 29:619–644 PubMedCrossRef

67.

Ingram JR, Collier F, Brown D, Burton T, Burton J, Chin MF, Desai N, Goodacre TEE, Piguet V, Pink AE, Exton LS, Mohd Mustapa MF (2019) British association of dermatologists guidelines for the management of hidradenitis suppurativa (acne inversa) 2018. Br J Dermatol 180:1009–1017 PubMedCrossRef

68.

Alikhan A, Sayed C, Alavi A, Alhusayen R, Brassard A, Burkhart C, Crowell K, Eisen DB, Gottlieb AB, Hamzavi I, Hazen PG, Jaleel T, Kimball AB, Kirby J, Lowes MA, Micheletti R, Miller A, Naik HB, Orgill D, Poulin Y (2019) North American clinical management guidelines for hidradenitis suppurativa: a publication from the United States and Canadian hidradenitis suppurativa foundations: part I: diagnosis, evaluation, and the use of complementary and procedural management. J Am Acad Dermatol 81:76–90 PubMedPubMedCentralCrossRef

69.

Alikhan A, Sayed C, Alavi A, Alhusayen R, Brassard A, Burkhart C, Crowell K, Eisen DB, Gottlieb AB, Hamzavi I, Hazen PG, Jaleel T, Kimball AB, Kirby J, Lowes MA, Micheletti R, Miller A, Naik HB, Orgill D, Poulin Y (2019) North American clinical management guidelines for hidradenitis suppurativa: a publication from the United States and Canadian hidradenitis suppurativa foundations: part II: topical, intralesional, and systemic medical management. J Am Acad Dermatol 81:91–101 PubMedPubMedCentralCrossRef

70.

Dauden E, Lazaro P, Aguilar MD, Blasco AJ, Suarez C, Marin I, Queiro R, Bassas-Vila J, Martorell A, Garcia-Campayo J (2018) Recommendations for the management of comorbidity in hidradenitis suppurativa. J Eur Acad Dermatol Venereol 32:129–144 PubMedCrossRef

71.

Clemmensen OJ (1983) Topical treatment of hidradenitis suppurativa with clindamycin. Int J Dermatol 22:325–328 PubMedCrossRef

72.

Fischer AH, Haskin A, Okoye GA (2017) Patterns of antimicrobial resistance in lesions of hidradenitis suppurativa. J Am Acad Dermatol 76:309–13.e2 PubMedCrossRef

73.

Riis PT, Boer J, Prens EP, Saunte DM, Deckers IE, Emtestam L, Sartorius K, Jemec GB (2016) Intralesional triamcinolone for flares of hidradenitis suppurativa (HS): a case series. J Am Acad Dermatol 75:1151–1155 PubMedCrossRef

74.

Mendonca CO, Griffiths CE (2006) Clindamycin and rifampicin combination therapy for hidradenitis suppurativa. Br J Dermatol 154:977–978 PubMedCrossRef

75.

van Straalen KR, Tzellos T, Guillem P, Benhadou F, Cuenca-Barrales C, Daxhelet M, Daoud M, Efthymiou O, Giamarellos-Bourboulis EJ, Jemec GBE, Katoulis AC, Koenig A, Lazaridou E, Marzano AV, Matusiak L, Molina-Leyva A, Moltrasio C, Pinter A, Potenza C, Romani J, Saunte DM, Skroza N, Stergianou D, Szepietowski J, Trigoni A, Vilarrasa E, van der Zee HH (2021) The efficacy and tolerability of tetracyclines and clindamycin plus rifampicin for the treatment of hidradenitis suppurativa: results of a prospective European cohort study. J Am Acad Dermatol 85:369–378 PubMedCrossRef

76.

Join-Lambert O, Coignard H, Jais JP, Guet-Revillet H, Poiree S, Fraitag S, Jullien V, Ribadeau-Dumas F, Theze J, Le Guern AS, Behillil S, Lefleche A, Berche P, Consigny PH, Lortholary O, Nassif X, Nassif A (2011) Efficacy of rifampin-moxifloxacin-metronidazole combination therapy in hidradenitis suppurativa. Dermatology 222:49–58 PubMedCrossRef

77.

Join-Lambert O, Coignard-Biehler H, Jais JP, Delage M, Guet-Revillet H, Poiree S, Duchatelet S, Jullien V, Hovnanian A, Lortholary O, Nassif X, Nassif A (2016) Efficacy of ertapenem in severe hidradenitis suppurativa: a pilot study in a cohort of 30 consecutive patients. J Antimicrob Chemother 71:513–520 PubMedCrossRef

78.

Yazdanyar S, Boer J, Ingvarsson G, Szepietowski JC, Jemec GB (2011) Dapsone therapy for hidradenitis suppurativa: a series of 24 patients. Dermatology 222:342–346 PubMedCrossRef

79.

Kimball AB, Okun MM, Williams DA, Gottlieb AB, Papp KA, Zouboulis CC, Armstrong AW, Kerdel F, Gold MH, Forman SB, Korman NJ, Giamarellos-Bourboulis EJ, Crowley JJ, Lynde C, Reguiai Z, Prens EP, Alwawi E, Mostafa NM, Pinsky B, Sundaram M, Gu Y, Carlson DM, Jemec GB (2016) Two phase 3 trials of adalimumab for hidradenitis suppurativa. N Engl J Med 375:422–434 PubMedCrossRef

80.

Zouboulis CC, Okun MM, Prens EP, Gniadecki R, Foley PA, Lynde C, Weisman J, Gu Y, Williams DA, Jemec GBE (2019) Long-term adalimumab efficacy in patients with moderate-to-severe hidradenitis suppurativa/acne inversa: 3‑year results of a phase 3 open-label extension study. J Am Acad Dermatol 80:60–69.e2 PubMedCrossRef

81.

Grant A, Gonzalez T, Montgomery MO, Cardenas V, Kerdel FA (2010) Infliximab therapy for patients with moderate to severe hidradenitis suppurativa: a randomized, double-blind, placebo-controlled crossover trial. J Am Acad Dermatol 62:205–217 PubMedCrossRef

82.

Ghias MH, Johnston AD, Kutner AJ, Micheletti RG, Hosgood HD, Cohen SR (2020) High-dose, high-frequency infliximab: a novel treatment paradigm for hidradenitis suppurativa. J Am Acad Dermatol 82:1094–1101 PubMedCrossRef

83.

Janse I, Bieniek A, Horvath B, Matusiak L (2016) Surgical procedures in hidradenitis suppurativa. Dermatol Clin 34:97–109 PubMedCrossRef

84.

Posch C, Monshi B, Quint T, Vujic I, Lilgenau N, Rappersberger K (2017) The role of wide local excision for the treatment of severe hidradenitis suppurativa (Hurley grade III): retrospective analysis of 74 patients. J Am Acad Dermatol 77:123–29.e5 PubMedCrossRef

85.

Harrison BJ, Mudge M, Hughes LE (1987) Recurrence after surgical treatment of hidradenitis suppurativa. Br Med J (Clin Res Ed) 294:487–489 CrossRef

86.

Morgan WP, Harding KG, Hughes LE (1983) A comparison of skin grafting and healing by granulation, following axillary excision for hidradenitis suppurativa. Ann R Coll Surg Engl 65:235–236 PubMedPubMedCentral

87.

van der Zee HH, Prens EP, Boer J (2010) Deroofing: a tissue-saving surgical technique for the treatment of mild to moderate hidradenitis suppurativa lesions. J Am Acad Dermatol 63:475–480 PubMedCrossRef

88.

Tierney E, Mahmoud BH, Hexsel C, Ozog D, Hamzavi I (2009) Randomized control trial for the treatment of hidradenitis suppurativa with a neodymium-doped yttrium aluminium garnet laser. Dermatol Surg 35:1188–1198 PubMedCrossRef

Titel: Hidradenitis suppurativa
verfasst von: Dr. Antonia Wiala
Theresa Stockinger
Christian Posch
Klemens Rappersberger
Publikationsdatum: 15.07.2022
Verlag: Springer Vienna
Erschienen in: hautnah / Ausgabe 3/2022
Print ISSN: 1866-2250
Elektronische ISSN: 2192-6484
DOI: https://doi.org/10.1007/s12326-022-00518-1

Springer Medizin Österreich

Tipp

Weitere Artikel dieser Ausgabe durch Wischen aufrufen

Hidradenitis suppurativa

Zusammenfassung

Springer Medizin Österreich

Tipp

Weitere Artikel dieser Ausgabe durch Wischen aufrufen

Zusammenfassung

Bitte loggen Sie sich ein, um Zugang zu diesem Inhalt zu erhalten

Weitere Artikel der Ausgabe 3/2022

Was bringt die adjuvante Therapie des Melanoms?

Bei Spaltnägeln vor allem an Tumoren denken!

Psoriasis: Wo juckt es am häufigsten?

Mastozytose

JAK-​Inhibitor Abrocitinib zeigt schnelle Wirksamkeit

Sind es Affenpocken? So klären Sie Verdachtsfälle ab

JAK-Inhibitor Abrocitinib zeigt schnelle Wirksamkeit