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Erschienen in: memo - Magazine of European Medical Oncology 3/2019

12.06.2019 | case report

Head and neck Langerhans cell histiocytosis: two case reports and review of the literature

verfasst von: Dr. Ilson Sepúlveda, Ignacio Mendoza, Romina Novoa, Geraldine Ayres, Nadia Inostroza, J Patricio Ulloa, Francisco Rivas-Rodriguez

Erschienen in: memo - Magazine of European Medical Oncology | Ausgabe 3/2019

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Summary

Langerhans cell histiocytosis (LCH) is an inflammatory neoplasia of myeloid precursor cells driven by mutations in the mitogen-activated protein kinase (MAPK) pathway. It can present as single or multisystem LCH. It occurs in 0.5–5.4 per million people. While it can occur at any age, it is more common in children, predominantly males, under the age of 4 years. The unifocal single system variety is the most prevalent and least aggressive presentation, making up to 70% of cases. It can affect bone (80%), lymph nodes (5–10%) or lungs (15%). The mandible and sphenoid are the least common locations; therefore, when present, it could be easily mistaken for a variety of pathologies. Depending on the clinical features, treatment can range from simple observation to chemotherapy and/or radiation. We present 2 cases of unifocal single system LCH located at the mandible and skull base, and describe the diagnostic work up and treatment.
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Metadaten
Titel
Head and neck Langerhans cell histiocytosis: two case reports and review of the literature
verfasst von
Dr. Ilson Sepúlveda
Ignacio Mendoza
Romina Novoa
Geraldine Ayres
Nadia Inostroza
J Patricio Ulloa
Francisco Rivas-Rodriguez
Publikationsdatum
12.06.2019
Verlag
Springer Vienna
Erschienen in
memo - Magazine of European Medical Oncology / Ausgabe 3/2019
Print ISSN: 1865-5041
Elektronische ISSN: 1865-5076
DOI
https://doi.org/10.1007/s12254-019-0500-y