Skip to main content
Erschienen in:

17.05.2022 | case report

Giant pedunculated liposarcoma of the esophagus

verfasst von: Mehmet Faik Ozcelik, MD, Sinan Carkman, MD, Ergin Erginoz, MD, BS, MSc, PhD, Gokce Hande Cavus, MD, Haktan Ovul Bozkir, MD

Erschienen in: European Surgery | Ausgabe 4/2022

Einloggen, um Zugang zu erhalten

Summary

Background

Liposarcoma is a common soft tissue neoplasm but its presence within the gastrointestinal system, especially the esophagus, is quite rare. It usually presents as an intraluminal or an intramural mass, with symptoms such as dysphagia and throat discomfort. Liposarcoma must be differentiated from benign tumors of the esophagus and managed appropriately.

Case presentation

In this report, we present the case of a 26-year-old woman who complained of dysphagia to liquids and solids and vague abdominal discomfort. The radiological modalities and endoscopic examination revealed a near-obstructing esophageal polypoid mass of 15 × 7.5 cm in size in the thoracal esophagus. A diagnosis of atypical lipomatous tumor/well-differentiated liposarcoma was made with morphological and immunohistochemical findings.

Discussion

Esophageal liposarcomas originate from primitive mesenchymal cells and are divided into several subtypes, with well-differentiated liposarcoma being the most common subtype. Various diagnostic tests are available, such as barium swallow, computerized tomography, magnetic resonance imaging, and esophagogastroduodenoscopy. Depending on the size and location of the tumor, minimally invasive endoscopic resection or more radical surgery such as esophagectomy can be performed.

Conclusion

Modern radiological imaging modalities have allowed better understanding and early diagnosis of lipomatous tumors of the esophagus. Optimal management varies, but minimally invasive techniques allow easy removal of the tumor stalk. However, more radical surgery such as esophagectomy is still performed. Due to its rarity, little is known about the prognosis of esophageal liposarcoma. Patients should be followed-up closely in the long term regarding recurrence.
Literatur
1.
Zurück zum Zitat Smith MA, Kluck E, Jagannath S, et al. Giant multi-polypoid liposarcoma of the esophagus: an atypical presentation. Ann Thorac Surg. 2010;89(2):610–2.CrossRef Smith MA, Kluck E, Jagannath S, et al. Giant multi-polypoid liposarcoma of the esophagus: an atypical presentation. Ann Thorac Surg. 2010;89(2):610–2.CrossRef
2.
Zurück zum Zitat Takiguchi G, Nakamura T, Otowa Y, et al. Successful resection of giant esophageal liposarcoma by endoscopic submucosal dissection combined with surgical retrieval: a case report and literature review. surg case rep. 2016;2(1):90.CrossRef Takiguchi G, Nakamura T, Otowa Y, et al. Successful resection of giant esophageal liposarcoma by endoscopic submucosal dissection combined with surgical retrieval: a case report and literature review. surg case rep. 2016;2(1):90.CrossRef
3.
Zurück zum Zitat Ye YW, Liao MY, Mou ZM, et al. Thoracoscopic resection of a huge esophageal dedifferentiated liposarcoma: a case report. World J Clin Cases. 2020;8(9):1698–704.CrossRef Ye YW, Liao MY, Mou ZM, et al. Thoracoscopic resection of a huge esophageal dedifferentiated liposarcoma: a case report. World J Clin Cases. 2020;8(9):1698–704.CrossRef
4.
Zurück zum Zitat Valiuddin HM, Barbetta A, Mungo B, et al. Esophageal liposarcoma: well-differentiated rhabdomyomatous type. World J Gastrointest Oncol. 2016;8(12):835–9.CrossRef Valiuddin HM, Barbetta A, Mungo B, et al. Esophageal liposarcoma: well-differentiated rhabdomyomatous type. World J Gastrointest Oncol. 2016;8(12):835–9.CrossRef
5.
Zurück zum Zitat Yang J, Ren Z, Du X, et al. The role of mesenchymal stem/progenitor cells in sarcoma: update and dispute. Stem Cell Investig. 2014;1:18.PubMedPubMedCentral Yang J, Ren Z, Du X, et al. The role of mesenchymal stem/progenitor cells in sarcoma: update and dispute. Stem Cell Investig. 2014;1:18.PubMedPubMedCentral
6.
Zurück zum Zitat Lin ZC, Chang XZ, Huang XF, et al. Giant liposarcoma of the esophagus: a case report. World J Gastroenterol. 2015;21(33):9827–32.CrossRef Lin ZC, Chang XZ, Huang XF, et al. Giant liposarcoma of the esophagus: a case report. World J Gastroenterol. 2015;21(33):9827–32.CrossRef
7.
Zurück zum Zitat Ortega P, Suster D, Falconieri G, Zambrano E, Moran CA, Morrison C, Suster S. Liposarcomas of the posterior mediastinum: clinicopathologic study of 18 cases. Mod Pathol. 2015;28(5):721–31.CrossRef Ortega P, Suster D, Falconieri G, Zambrano E, Moran CA, Morrison C, Suster S. Liposarcomas of the posterior mediastinum: clinicopathologic study of 18 cases. Mod Pathol. 2015;28(5):721–31.CrossRef
8.
Zurück zum Zitat Beaudoin A, Journet C, Watier A, et al. Giant liposarcoma of the esophagus. Can J Gastroenterol. 2002;16(6):377–9.CrossRef Beaudoin A, Journet C, Watier A, et al. Giant liposarcoma of the esophagus. Can J Gastroenterol. 2002;16(6):377–9.CrossRef
9.
Zurück zum Zitat Jakowski JD, Wakely PE Jr.. Rhabdomyomatous well-differentiated liposarcoma arising in giant fibrovascular polyp of the esophagus. Ann Diagn Pathol. 2009;13(4):263–8.CrossRef Jakowski JD, Wakely PE Jr.. Rhabdomyomatous well-differentiated liposarcoma arising in giant fibrovascular polyp of the esophagus. Ann Diagn Pathol. 2009;13(4):263–8.CrossRef
10.
Zurück zum Zitat Parikh MP, Chandran A, Satiya J, et al. Dedifferentiated liposarcoma in a giant esophageal polyp: a case report and review of the literature. Cureus. 2019;11(4):e4480.PubMedPubMedCentral Parikh MP, Chandran A, Satiya J, et al. Dedifferentiated liposarcoma in a giant esophageal polyp: a case report and review of the literature. Cureus. 2019;11(4):e4480.PubMedPubMedCentral
11.
Zurück zum Zitat Graham RP, Yasir S, Fritchie KJ, et al. Polypoid fibro adipose tumors of the esophagus: ‘giant fibrovascular polyp’ or liposarcoma? A clinicopathological and molecular cytogenetic study of 13 cases. Mod Pathol. 2018;31(2):337–42.CrossRef Graham RP, Yasir S, Fritchie KJ, et al. Polypoid fibro adipose tumors of the esophagus: ‘giant fibrovascular polyp’ or liposarcoma? A clinicopathological and molecular cytogenetic study of 13 cases. Mod Pathol. 2018;31(2):337–42.CrossRef
12.
Zurück zum Zitat Sirvent N, Coindre JM, Maire G, et al. Detection of MDM2-CDK4 amplification by fluorescence in situ hybridization in 200 paraffin-embedded tumor samples: utility in diagnosing adipocytic lesions and comparison with immunohistochemistry and real-time PCR. Am J Surg Pathol. 2007;31(10):1476–89.CrossRef Sirvent N, Coindre JM, Maire G, et al. Detection of MDM2-CDK4 amplification by fluorescence in situ hybridization in 200 paraffin-embedded tumor samples: utility in diagnosing adipocytic lesions and comparison with immunohistochemistry and real-time PCR. Am J Surg Pathol. 2007;31(10):1476–89.CrossRef
13.
Zurück zum Zitat Myung JK, Jeong JB, Han D, et al. Well-differentiated liposarcoma of the oesophagus: clinicopathological, immunohistochemical and array CGH analysis. Pathol Oncol Res. 2011;17(2):415–20.CrossRef Myung JK, Jeong JB, Han D, et al. Well-differentiated liposarcoma of the oesophagus: clinicopathological, immunohistochemical and array CGH analysis. Pathol Oncol Res. 2011;17(2):415–20.CrossRef
14.
Zurück zum Zitat Yang B, Shi PZ, Li X, et al. Well-differentiated liposarcoma of esophagus. Chin Med J. 2006;119(5):438–40.CrossRef Yang B, Shi PZ, Li X, et al. Well-differentiated liposarcoma of esophagus. Chin Med J. 2006;119(5):438–40.CrossRef
15.
Zurück zum Zitat Liakakos TD, Troupis TG, Tzathas C, et al. Primary liposarcoma of esophagus: a case report. World J Gastroenterol. 2006;12:114952.CrossRef Liakakos TD, Troupis TG, Tzathas C, et al. Primary liposarcoma of esophagus: a case report. World J Gastroenterol. 2006;12:114952.CrossRef
16.
Zurück zum Zitat Ferrari D, Bernardi D, Siboni S, et al. Esophageal lipoma and liposarcoma: a systematic review. World J Surg. 2021;45(1):225–34.CrossRef Ferrari D, Bernardi D, Siboni S, et al. Esophageal lipoma and liposarcoma: a systematic review. World J Surg. 2021;45(1):225–34.CrossRef
17.
Zurück zum Zitat Baldaque-Silva F, Marques M, Sanchez-Hernandez E, et al. Endoscopic submucosal dissection of a giant esophageal lipoma. Am J Gastroenterol. 2016;111:1680.CrossRef Baldaque-Silva F, Marques M, Sanchez-Hernandez E, et al. Endoscopic submucosal dissection of a giant esophageal lipoma. Am J Gastroenterol. 2016;111:1680.CrossRef
18.
Zurück zum Zitat Ferro RM, Pinilla Morales R. Advanced endoscopic resection using endoscopic submucosal dissection technique to resect a giant, lumen-occluding esophageal polyp. Endoscopy. 2019;51(6):E151–E2.CrossRef Ferro RM, Pinilla Morales R. Advanced endoscopic resection using endoscopic submucosal dissection technique to resect a giant, lumen-occluding esophageal polyp. Endoscopy. 2019;51(6):E151–E2.CrossRef
19.
Zurück zum Zitat Enzinger FM, Winslow DJ. Liposarcoma. Virchows Arch A Pathol Anat. 1962;335:367–88.CrossRef Enzinger FM, Winslow DJ. Liposarcoma. Virchows Arch A Pathol Anat. 1962;335:367–88.CrossRef
Metadaten
Titel
Giant pedunculated liposarcoma of the esophagus
verfasst von
Mehmet Faik Ozcelik, MD
Sinan Carkman, MD
Ergin Erginoz, MD, BS, MSc, PhD
Gokce Hande Cavus, MD
Haktan Ovul Bozkir, MD
Publikationsdatum
17.05.2022
Verlag
Springer Vienna
Erschienen in
European Surgery / Ausgabe 4/2022
Print ISSN: 1682-8631
Elektronische ISSN: 1682-4016
DOI
https://doi.org/10.1007/s10353-022-00764-w