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Erschienen in: Wiener Medizinische Wochenschrift 23-24/2015

01.12.2015 | case report

Giant extragenital Bowen’s disease

verfasst von: Assoc. Prof. Ilko Bakardzhiev, Dr. Anastasiya Atanasova Chokoeva, Assoc. Prof. Georgi Tchernev

Erschienen in: Wiener Medizinische Wochenschrift | Ausgabe 23-24/2015

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Summary

Giant extragenital forms of Morbus Bowen are extremely rare. The already described cases in the word literature are most commonly with periungual localization, as well as located on the foot and neck area. The clinical manifestation is presented most commonly by non-specific erythematous to erythematous-squamous plaques or papules, which is confusing to the clinician. From the pathogenic point of view, it is important to be confirmed or rejected the presence of human papilloma viruses (HPVs) in each case of affected patient, as this information is mandatory in respect to the adequate selection of the subsequent regimen. If HPVs are detected, systemic antiviral therapy could be initiated to reduce the size of the lesions before subsequent surgical eradication. A postoperative prevention through vaccination could be also considered additionally. In cases of HPV-negative giant extragenital forms of Morbus Bowen (as in the described patient), the focus should be on local immunomodulation by substances such as imiquimod, which reduce the size of the lesions, thereby creating optimal opportunities for their future surgical eradication. Other possible options described in the literature include topical application of 5-fluorouracil, photodynamic therapy, cryotherapy, and laser therapy (carbon dioxide laser). The choice of the most appropriate regimen should have been an individual decision of the clinician, considering also the location and the extent of the lesion.
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Metadaten
Titel
Giant extragenital Bowen’s disease
verfasst von
Assoc. Prof. Ilko Bakardzhiev
Dr. Anastasiya Atanasova Chokoeva
Assoc. Prof. Georgi Tchernev
Publikationsdatum
01.12.2015
Verlag
Springer Vienna
Erschienen in
Wiener Medizinische Wochenschrift / Ausgabe 23-24/2015
Print ISSN: 0043-5341
Elektronische ISSN: 1563-258X
DOI
https://doi.org/10.1007/s10354-015-0396-z