Skip to main content

Tipp

Weitere Artikel dieser Ausgabe durch Wischen aufrufen

Erschienen in: Journal für Urologie und Urogynäkologie/Österreich 4/2019

17.07.2019 | Originalien

Genetik des Prostatakarzinoms

verfasst von: Dr. David Schörghofer, Univ. Prof. Dr. Gökhan Uyanik, OÄ Dr. Katharina Rötzer

Erschienen in: Journal für Urologie und Urogynäkologie/Österreich | Ausgabe 4/2019

Einloggen, um Zugang zu erhalten

Zusammenfassung

Das Prostatakarzinom stellt die häufigste Krebserkrankung und die dritthäufigste Krebstodesursache bei Männern in Europa dar. Die Möglichkeiten der Behandlung und Früherkennung des Prostatakarzinoms nahmen in den letzten Jahren deutlich zu. Von großer Wichtigkeit ist dabei auch die Identifizierung von Patientengruppen, die ein besonders hohes Risiko haben, ein Prostatakarzinom zu entwickeln, um sie einem gezielten, intensivierten Früherkennungsprogramm zuzuführen. Es wird vermutet, dass bei etwa 10 % der Männer genetische Ursachen im Rahmen eines monogen vererbten Tumorsyndroms für die Entstehung des Prostatakarzinoms verantwortlich sind. Die am häufigsten mit Prostatakarzinom in Verbindung gebrachten Gene sind BRCA1, BRCA2 und HOXB13, die zusammengenommen etwa 40 % der genetisch bedingten Prostatakarzinome verursachen. Daneben wird der Einfluss zahlreicher anderer Gene, wie u. a. der sog. Lynch-Syndrom-Gene, diskutiert. Mutationen der BRCA1- und BRCA2-Gene haben auch einen bedeutenden Einfluss auf die Eigenschaften, die Prognose und den Verlauf des Prostatakarzinoms. Des Weiteren gibt es Hinweise dafür, dass Prostatakarzinome basierend auf BRCA-Keimbahnmutationen, ähnlich wie bei Brust- und Eierstockkrebs, besser auf platinbasierte Therapien ansprechen. Auch neue Therapien, wie PARP-Inhibitoren, könnten zukünftig in bestimmten Fällen zum Einsatz kommen. In jedem Fall ermöglicht der Nachweis einer familiären Mutation bei einem Prostatakarzinompatienten eine prädiktive Testung von Angehörigen zur Beurteilung des individuellen Tumorrisikos mit der Möglichkeit einer engmaschigen Früherkennung für Hochrisikopersonen und der Entlastung jener, die die Mutation nicht geerbt haben.
Literatur
1.
Zurück zum Zitat Bray F, Kiemeney LA (2017) Epidemiology of prostate cancer in europe: patterns, trends and determinants. In: Bolla M, van Poppel H (Hrsg) Management of prostate cancer. Springer, Cham Bray F, Kiemeney LA (2017) Epidemiology of prostate cancer in europe: patterns, trends and determinants. In: Bolla M, van Poppel H (Hrsg) Management of prostate cancer. Springer, Cham
2.
Zurück zum Zitat Crocetti E (2015) Epidemiology of prostate cancer in Europe. Centre for Parliamentary Studies Crocetti E (2015) Epidemiology of prostate cancer in Europe. Centre for Parliamentary Studies
3.
Zurück zum Zitat Statistik Austria (2018) Jahrbuch der Gesundheitsstatistik 2016 Statistik Austria (2018) Jahrbuch der Gesundheitsstatistik 2016
4.
Zurück zum Zitat Siegel RL, Miller KD, Jemal A (2018) Cancer statistics, 2018. Cancer J Clin 68(1):7–30 Siegel RL, Miller KD, Jemal A (2018) Cancer statistics, 2018. Cancer J Clin 68(1):7–30
7.
Zurück zum Zitat Patel AR, Klein EA (2009) Risk factors for prostate cancer. Nat Clin Pract Urol 6(2):87–95 PubMed Patel AR, Klein EA (2009) Risk factors for prostate cancer. Nat Clin Pract Urol 6(2):87–95 PubMed
8.
Zurück zum Zitat Bell KJ, Del Mar C, Wright G, Dickinson J, Glasziou P (2015) Prevalence of incidental prostate cancer: a systematic review of autopsy studies. Int J Cancer 137(7):1749–1757 PubMedPubMedCentral Bell KJ, Del Mar C, Wright G, Dickinson J, Glasziou P (2015) Prevalence of incidental prostate cancer: a systematic review of autopsy studies. Int J Cancer 137(7):1749–1757 PubMedPubMedCentral
9.
Zurück zum Zitat Dong C, Hemminki K (2001) Modification of cancer risks in offspring by sibling and parental cancers from 2,112,616 nuclear families. Int J Cancer 92(1):144–150 PubMed Dong C, Hemminki K (2001) Modification of cancer risks in offspring by sibling and parental cancers from 2,112,616 nuclear families. Int J Cancer 92(1):144–150 PubMed
10.
Zurück zum Zitat Hemminki K, Czene K (2002) Age specific and attributable risks of familial prostate carcinoma from the family-cancer database. Cancer 95(6):1346–1353 PubMed Hemminki K, Czene K (2002) Age specific and attributable risks of familial prostate carcinoma from the family-cancer database. Cancer 95(6):1346–1353 PubMed
11.
Zurück zum Zitat McWhorter WP, Hernandez AD, Meikle AW, Terreros DA, Smith JA Jr., Skolnick MH, Cannon-Albright LA, Eyre HJ (1992) A screening study of prostate cancer in high risk families. J Urol 148(3):826–828 PubMed McWhorter WP, Hernandez AD, Meikle AW, Terreros DA, Smith JA Jr., Skolnick MH, Cannon-Albright LA, Eyre HJ (1992) A screening study of prostate cancer in high risk families. J Urol 148(3):826–828 PubMed
12.
Zurück zum Zitat Elshafei A, Moussa AS, Hatem A, Ethan V, Panumatrassamee K, Hernandez AV, Jones JS (2013) Does positive family history of prostate cancer increase the risk of prostate cancer on initial prostate biopsy? Urology 81(4):826–830 PubMed Elshafei A, Moussa AS, Hatem A, Ethan V, Panumatrassamee K, Hernandez AV, Jones JS (2013) Does positive family history of prostate cancer increase the risk of prostate cancer on initial prostate biopsy? Urology 81(4):826–830 PubMed
13.
Zurück zum Zitat Zeegers MP, Jellema A, Ostrer H (2003) Empiric risk of prostate carcinoma for relatives of patients with prostate carcinoma: a meta-analysis. Cancer 97(8):1894–1903 PubMed Zeegers MP, Jellema A, Ostrer H (2003) Empiric risk of prostate carcinoma for relatives of patients with prostate carcinoma: a meta-analysis. Cancer 97(8):1894–1903 PubMed
14.
Zurück zum Zitat Carter BS, Beaty TH, Steinberg GD, Childs B, Walsh PC (1992) Mendelian inheritance of familial prostate cancer. Proc Natl Acad Sci USA 89(8):3367–3371 PubMedPubMedCentral Carter BS, Beaty TH, Steinberg GD, Childs B, Walsh PC (1992) Mendelian inheritance of familial prostate cancer. Proc Natl Acad Sci USA 89(8):3367–3371 PubMedPubMedCentral
15.
Zurück zum Zitat Breast Cancer Linkage C (1999) Cancer risks in BRCA2 mutation carriers. J Natl Cancer Inst 91(15):1310–1316 Breast Cancer Linkage C (1999) Cancer risks in BRCA2 mutation carriers. J Natl Cancer Inst 91(15):1310–1316
16.
Zurück zum Zitat Lecarpentier J, Silvestri V, Kuchenbaecker KB, Barrowdale D, Dennis J, McGuffog L, Soucy P, Leslie G, Rizzolo P, Navazio AS et al (2017) Prediction of breast and prostate cancer risks in Male BRCA1 and BRCA2 mutation carriers using polygenic risk scores. J Clin Oncol 35(20):2240–2250 PubMedPubMedCentral Lecarpentier J, Silvestri V, Kuchenbaecker KB, Barrowdale D, Dennis J, McGuffog L, Soucy P, Leslie G, Rizzolo P, Navazio AS et al (2017) Prediction of breast and prostate cancer risks in Male BRCA1 and BRCA2 mutation carriers using polygenic risk scores. J Clin Oncol 35(20):2240–2250 PubMedPubMedCentral
17.
Zurück zum Zitat van Asperen CJ, Brohet RM, Meijers-Heijboer EJ, Hoogerbrugge N, Verhoef S, Vasen HF, Ausems MG, Menko FH, Gomez Garcia EB, Klijn JG et al (2005) Cancer risks in BRCA2 families: estimates for sites other than breast and ovary. J Med Genet 42(9):711–719 PubMedPubMedCentral van Asperen CJ, Brohet RM, Meijers-Heijboer EJ, Hoogerbrugge N, Verhoef S, Vasen HF, Ausems MG, Menko FH, Gomez Garcia EB, Klijn JG et al (2005) Cancer risks in BRCA2 families: estimates for sites other than breast and ovary. J Med Genet 42(9):711–719 PubMedPubMedCentral
18.
Zurück zum Zitat Edwards SM, Kote-Jarai Z, Meitz J, Hamoudi R, Hope Q, Osin P, Jackson R, Southgate C, Singh R, Falconer A et al (2003) Two percent of men with early-onset prostate cancer harbor germline mutations in the BRCA2 gene. Am J Hum Genet 72(1):1–12 PubMed Edwards SM, Kote-Jarai Z, Meitz J, Hamoudi R, Hope Q, Osin P, Jackson R, Southgate C, Singh R, Falconer A et al (2003) Two percent of men with early-onset prostate cancer harbor germline mutations in the BRCA2 gene. Am J Hum Genet 72(1):1–12 PubMed
19.
Zurück zum Zitat Kote-Jarai Z, Leongamornlert D, Saunders E, Tymrakiewicz M, Castro E, Mahmud N, Guy M, Edwards S, O’Brien L, Sawyer E et al (2011) BRCA2 is a moderate penetrance gene contributing to young-onset prostate cancer: implications for genetic testing in prostate cancer patients. Br J Cancer 105(8):1230–1234 PubMedPubMedCentral Kote-Jarai Z, Leongamornlert D, Saunders E, Tymrakiewicz M, Castro E, Mahmud N, Guy M, Edwards S, O’Brien L, Sawyer E et al (2011) BRCA2 is a moderate penetrance gene contributing to young-onset prostate cancer: implications for genetic testing in prostate cancer patients. Br J Cancer 105(8):1230–1234 PubMedPubMedCentral
20.
Zurück zum Zitat Leongamornlert D, Mahmud N, Tymrakiewicz M, Saunders E, Dadaev T, Castro E, Goh C, Govindasami K, Guy M, O’Brien L et al (2012) Germline BRCA1 mutations increase prostate cancer risk. Br J Cancer 106(10):1697–1701 PubMedPubMedCentral Leongamornlert D, Mahmud N, Tymrakiewicz M, Saunders E, Dadaev T, Castro E, Goh C, Govindasami K, Guy M, O’Brien L et al (2012) Germline BRCA1 mutations increase prostate cancer risk. Br J Cancer 106(10):1697–1701 PubMedPubMedCentral
21.
Zurück zum Zitat Pritchard CC, Mateo J, Walsh MF, De Sarkar N, Abida W, Beltran H, Garofalo A, Gulati R, Carreira S, Eeles R et al (2016) Inherited DNA-repair gene mutations in men with metastatic prostate cancer. N Engl J Med 375(5):443–453 PubMedPubMedCentral Pritchard CC, Mateo J, Walsh MF, De Sarkar N, Abida W, Beltran H, Garofalo A, Gulati R, Carreira S, Eeles R et al (2016) Inherited DNA-repair gene mutations in men with metastatic prostate cancer. N Engl J Med 375(5):443–453 PubMedPubMedCentral
23.
Zurück zum Zitat Castro E, Goh C, Olmos D, Saunders E, Leongamornlert D, Tymrakiewicz M, Mahmud N, Dadaev T, Govindasami K, Guy M et al (2013) Germline BRCA mutations are associated with higher risk of nodal involvement, distant metastasis, and poor survival outcomes in prostate cancer. J Clin Oncol 31(14):1748–1757 PubMedPubMedCentral Castro E, Goh C, Olmos D, Saunders E, Leongamornlert D, Tymrakiewicz M, Mahmud N, Dadaev T, Govindasami K, Guy M et al (2013) Germline BRCA mutations are associated with higher risk of nodal involvement, distant metastasis, and poor survival outcomes in prostate cancer. J Clin Oncol 31(14):1748–1757 PubMedPubMedCentral
24.
Zurück zum Zitat Mitra A, Fisher C, Foster CS, Jameson C, Barbachanno Y, Bartlett J, Bancroft E, Doherty R, Kote-Jarai Z, Peock S et al (2008) Prostate cancer in male BRCA1 and BRCA2 mutation carriers has a more aggressive phenotype. Br J Cancer 98(2):502–507 PubMedPubMedCentral Mitra A, Fisher C, Foster CS, Jameson C, Barbachanno Y, Bartlett J, Bancroft E, Doherty R, Kote-Jarai Z, Peock S et al (2008) Prostate cancer in male BRCA1 and BRCA2 mutation carriers has a more aggressive phenotype. Br J Cancer 98(2):502–507 PubMedPubMedCentral
25.
Zurück zum Zitat Tryggvadottir L, Vidarsdottir L, Thorgeirsson T, Jonasson JG, Olafsdottir EJ, Olafsdottir GH, Rafnar T, Thorlacius S, Jonsson E, Eyfjord JE et al (2007) Prostate cancer progression and survival in BRCA2 mutation carriers. J Natl Cancer Inst 99(12):929–935 PubMed Tryggvadottir L, Vidarsdottir L, Thorgeirsson T, Jonasson JG, Olafsdottir EJ, Olafsdottir GH, Rafnar T, Thorlacius S, Jonsson E, Eyfjord JE et al (2007) Prostate cancer progression and survival in BRCA2 mutation carriers. J Natl Cancer Inst 99(12):929–935 PubMed
26.
Zurück zum Zitat Gallagher DJ, Gaudet MM, Pal P, Kirchhoff T, Balistreri L, Vora K, Bhatia J, Stadler Z, Fine SW, Reuter V et al (2010) Germline BRCA mutations denote a clinicopathologic subset of prostate cancer. Clin Cancer Res 16(7):2115–2121 PubMedPubMedCentral Gallagher DJ, Gaudet MM, Pal P, Kirchhoff T, Balistreri L, Vora K, Bhatia J, Stadler Z, Fine SW, Reuter V et al (2010) Germline BRCA mutations denote a clinicopathologic subset of prostate cancer. Clin Cancer Res 16(7):2115–2121 PubMedPubMedCentral
27.
Zurück zum Zitat Kathleen Cunningham Consortium for Research in Familial Breast Cancer C, Thorne H, Willems AJ, Niedermayr E, Hoh IM, Li J, Clouston D, Mitchell G, Fox S, Hopper JL et al (2011) Decreased prostate cancer-specific survival of men with BRCA2 mutations from multiple breast cancer families. Cancer Prev Res 4(7):1002–1010 Kathleen Cunningham Consortium for Research in Familial Breast Cancer C, Thorne H, Willems AJ, Niedermayr E, Hoh IM, Li J, Clouston D, Mitchell G, Fox S, Hopper JL et al (2011) Decreased prostate cancer-specific survival of men with BRCA2 mutations from multiple breast cancer families. Cancer Prev Res 4(7):1002–1010
28.
Zurück zum Zitat Edwards SM, Evans DG, Hope Q, Norman AR, Barbachano Y, Bullock S, Kote-Jarai Z, Meitz J, Falconer A, Osin P et al (2010) Prostate cancer in BRCA2 germline mutation carriers is associated with poorer prognosis. Br J Cancer 103(6):918–924 PubMedPubMedCentral Edwards SM, Evans DG, Hope Q, Norman AR, Barbachano Y, Bullock S, Kote-Jarai Z, Meitz J, Falconer A, Osin P et al (2010) Prostate cancer in BRCA2 germline mutation carriers is associated with poorer prognosis. Br J Cancer 103(6):918–924 PubMedPubMedCentral
29.
Zurück zum Zitat Bratt O, Loman N (2015) Clinical management of prostate cancer in men with BRCA mutations. Eur Urol 68(2):194–195 PubMed Bratt O, Loman N (2015) Clinical management of prostate cancer in men with BRCA mutations. Eur Urol 68(2):194–195 PubMed
30.
Zurück zum Zitat Pomerantz MM, Spisak S, Jia L, Cronin AM, Csabai I, Ledet E, Sartor AO, Rainville I, O’Connor EP, Herbert ZT et al (2017) The association between germline BRCA2 variants and sensitivity to platinum-based chemotherapy among men with metastatic prostate cancer. Cancer 123(18):3532–3539 PubMed Pomerantz MM, Spisak S, Jia L, Cronin AM, Csabai I, Ledet E, Sartor AO, Rainville I, O’Connor EP, Herbert ZT et al (2017) The association between germline BRCA2 variants and sensitivity to platinum-based chemotherapy among men with metastatic prostate cancer. Cancer 123(18):3532–3539 PubMed
31.
Zurück zum Zitat Kaufman B, Shapira-Frommer R, Schmutzler RK, Audeh MW, Friedlander M, Balmana J, Mitchell G, Fried G, Stemmer SM, Hubert A et al (2015) Olaparib monotherapy in patients with advanced cancer and a germline BRCA1/2 mutation. J Clin Oncol 33(3):244–250 PubMed Kaufman B, Shapira-Frommer R, Schmutzler RK, Audeh MW, Friedlander M, Balmana J, Mitchell G, Fried G, Stemmer SM, Hubert A et al (2015) Olaparib monotherapy in patients with advanced cancer and a germline BRCA1/2 mutation. J Clin Oncol 33(3):244–250 PubMed
32.
Zurück zum Zitat Mateo J, Carreira S, Sandhu S, Miranda S, Mossop H, Perez-Lopez R, Nava Rodrigues D, Robinson D, Omlin A, Tunariu N et al (2015) DNA-repair defects and olaparib in metastatic prostate cancer. N Engl J Med 373(18):1697–1708 PubMedPubMedCentral Mateo J, Carreira S, Sandhu S, Miranda S, Mossop H, Perez-Lopez R, Nava Rodrigues D, Robinson D, Omlin A, Tunariu N et al (2015) DNA-repair defects and olaparib in metastatic prostate cancer. N Engl J Med 373(18):1697–1708 PubMedPubMedCentral
33.
Zurück zum Zitat Castro E, Goh C, Leongamornlert D, Saunders E, Tymrakiewicz M, Dadaev T, Govindasami K, Guy M, Ellis S, Frost D et al (2015) Effect of BRCA mutations on metastatic relapse and cause-specific survival after radical treatment for localised prostate cancer. Eur Urol 68(2):186–193 PubMed Castro E, Goh C, Leongamornlert D, Saunders E, Tymrakiewicz M, Dadaev T, Govindasami K, Guy M, Ellis S, Frost D et al (2015) Effect of BRCA mutations on metastatic relapse and cause-specific survival after radical treatment for localised prostate cancer. Eur Urol 68(2):186–193 PubMed
34.
Zurück zum Zitat Bancroft EK, Page EC, Castro E, Lilja H, Vickers A, Sjoberg D, Assel M, Foster CS, Mitchell G, Drew K et al (2014) Targeted prostate cancer screening in BRCA1 and BRCA2 mutation carriers: results from the initial screening round of the IMPACT study. Eur Urol 66(3):489–499 PubMedPubMedCentral Bancroft EK, Page EC, Castro E, Lilja H, Vickers A, Sjoberg D, Assel M, Foster CS, Mitchell G, Drew K et al (2014) Targeted prostate cancer screening in BRCA1 and BRCA2 mutation carriers: results from the initial screening round of the IMPACT study. Eur Urol 66(3):489–499 PubMedPubMedCentral
35.
Zurück zum Zitat Robinson D, Van Allen EM, Wu YM, Schultz N, Lonigro RJ, Mosquera JM, Montgomery B, Taplin ME, Pritchard CC, Attard G et al (2015) Integrative clinical genomics of advanced prostate cancer. Cell 161(5):1215–1228 PubMedPubMedCentral Robinson D, Van Allen EM, Wu YM, Schultz N, Lonigro RJ, Mosquera JM, Montgomery B, Taplin ME, Pritchard CC, Attard G et al (2015) Integrative clinical genomics of advanced prostate cancer. Cell 161(5):1215–1228 PubMedPubMedCentral
36.
Zurück zum Zitat Daly MB, Pilarski R, Berry M, Buys SS, Friedman S, Garber JE, Klein C, Kohlmann W, Kurian A, Laronga C et al (2018) NCCN clinical practice guidelines in oncology. Genetic/familial high-risk assessement: breast and ovarian 2.2019. National comprehensive cancer network (NCCN) Daly MB, Pilarski R, Berry M, Buys SS, Friedman S, Garber JE, Klein C, Kohlmann W, Kurian A, Laronga C et al (2018) NCCN clinical practice guidelines in oncology. Genetic/familial high-risk assessement: breast and ovarian 2.2019. National comprehensive cancer network (NCCN)
37.
Zurück zum Zitat Ewing CM, Ray AM, Lange EM, Zuhlke KA, Robbins CM, Tembe WD, Wiley KE, Isaacs SD, Johng D, Wang Y et al (2012) Germline mutations in HOXB13 and prostate-cancer risk. N Engl J Med 366(2):141–149 PubMedPubMedCentral Ewing CM, Ray AM, Lange EM, Zuhlke KA, Robbins CM, Tembe WD, Wiley KE, Isaacs SD, Johng D, Wang Y et al (2012) Germline mutations in HOXB13 and prostate-cancer risk. N Engl J Med 366(2):141–149 PubMedPubMedCentral
38.
Zurück zum Zitat Lange EM, Gillanders EM, Davis CC, Brown WM, Campbell JK, Jones M, Gildea D, Riedesel E, Albertus J, Freas-Lutz D et al (2003) Genome-wide scan for prostate cancer susceptibility genes using families from the University of Michigan prostate cancer genetics project finds evidence for linkage on chromosome 17 near BRCA1. Prostate 57(4):326–334 PubMed Lange EM, Gillanders EM, Davis CC, Brown WM, Campbell JK, Jones M, Gildea D, Riedesel E, Albertus J, Freas-Lutz D et al (2003) Genome-wide scan for prostate cancer susceptibility genes using families from the University of Michigan prostate cancer genetics project finds evidence for linkage on chromosome 17 near BRCA1. Prostate 57(4):326–334 PubMed
39.
Zurück zum Zitat Xu J, Dimitrov L, Chang BL, Adams TS, Turner AR, Meyers DA, Eeles RA, Easton DF, Foulkes WD, Simard J et al (2005) A combined genomewide linkage scan of 1,233 families for prostate cancer-susceptibility genes conducted by the international consortium for prostate cancer genetics. Am J Hum Genet 77(2):219–229 PubMedPubMedCentral Xu J, Dimitrov L, Chang BL, Adams TS, Turner AR, Meyers DA, Eeles RA, Easton DF, Foulkes WD, Simard J et al (2005) A combined genomewide linkage scan of 1,233 families for prostate cancer-susceptibility genes conducted by the international consortium for prostate cancer genetics. Am J Hum Genet 77(2):219–229 PubMedPubMedCentral
40.
Zurück zum Zitat Zuhlke KA, Madeoy JJ, Beebe-Dimmer J, White KA, Griffin A, Lange EM, Gruber SB, Ostrander EA, Cooney KA (2004) Truncating BRCA1 mutations are uncommon in a cohort of hereditary prostate cancer families with evidence of linkage to 17q markers. Clin Cancer Res 10(18 Pt 1):5975–5980 PubMed Zuhlke KA, Madeoy JJ, Beebe-Dimmer J, White KA, Griffin A, Lange EM, Gruber SB, Ostrander EA, Cooney KA (2004) Truncating BRCA1 mutations are uncommon in a cohort of hereditary prostate cancer families with evidence of linkage to 17q markers. Clin Cancer Res 10(18 Pt 1):5975–5980 PubMed
41.
Zurück zum Zitat Laitinen VH, Wahlfors T, Saaristo L, Rantapero T, Pelttari LM, Kilpivaara O, Laasanen SL, Kallioniemi A, Nevanlinna H, Aaltonen L et al (2013) HOXB13 G84E mutation in Finland: population-based analysis of prostate, breast, and colorectal cancer risk. Cancer Epidemiol Biomarkers Prev 22(3):452–460 PubMed Laitinen VH, Wahlfors T, Saaristo L, Rantapero T, Pelttari LM, Kilpivaara O, Laasanen SL, Kallioniemi A, Nevanlinna H, Aaltonen L et al (2013) HOXB13 G84E mutation in Finland: population-based analysis of prostate, breast, and colorectal cancer risk. Cancer Epidemiol Biomarkers Prev 22(3):452–460 PubMed
42.
Zurück zum Zitat Beebe-Dimmer JL, Hathcock M, Yee C, Okoth LA, Ewing CM, Isaacs WB, Cooney KA, Thibodeau SN (2015) The HOXB13 G84E mutation is associated with an increased risk for prostate cancer and other malignancies. Cancer Epidemiol Biomarkers Prev 24(9):1366–1372 PubMedPubMedCentral Beebe-Dimmer JL, Hathcock M, Yee C, Okoth LA, Ewing CM, Isaacs WB, Cooney KA, Thibodeau SN (2015) The HOXB13 G84E mutation is associated with an increased risk for prostate cancer and other malignancies. Cancer Epidemiol Biomarkers Prev 24(9):1366–1372 PubMedPubMedCentral
43.
Zurück zum Zitat Lin X, Qu L, Chen Z, Xu C, Ye D, Shao Q, Wang X, Qi J, Chen Z, Zhou F et al (2013) A novel germline mutation in HOXB13 is associated with prostate cancer risk in Chinese men. Prostate 73(2):169–175 PubMed Lin X, Qu L, Chen Z, Xu C, Ye D, Shao Q, Wang X, Qi J, Chen Z, Zhou F et al (2013) A novel germline mutation in HOXB13 is associated with prostate cancer risk in Chinese men. Prostate 73(2):169–175 PubMed
44.
Zurück zum Zitat Karlsson R, Aly M, Clements M, Zheng L, Adolfsson J, Xu J, Gronberg H, Wiklund F (2014) A population-based assessment of germline HOXB13 G84E mutation and prostate cancer risk. Eur Urol 65(1):169–176 PubMed Karlsson R, Aly M, Clements M, Zheng L, Adolfsson J, Xu J, Gronberg H, Wiklund F (2014) A population-based assessment of germline HOXB13 G84E mutation and prostate cancer risk. Eur Urol 65(1):169–176 PubMed
45.
Zurück zum Zitat Chen Z, Greenwood C, Isaacs WB, Foulkes WD, Sun J, Zheng SL, Condreay LD, Xu J (2013) The G84E mutation of HOXB13 is associated with increased risk for prostate cancer: results from the REDUCE trial. Carcinogenesis 34(6):1260–1264 PubMedPubMedCentral Chen Z, Greenwood C, Isaacs WB, Foulkes WD, Sun J, Zheng SL, Condreay LD, Xu J (2013) The G84E mutation of HOXB13 is associated with increased risk for prostate cancer: results from the REDUCE trial. Carcinogenesis 34(6):1260–1264 PubMedPubMedCentral
46.
Zurück zum Zitat Kote-Jarai Z, Mikropoulos C, Leongamornlert DA, Dadaev T, Tymrakiewicz M, Saunders EJ, Jones M, Jugurnauth-Little S, Govindasami K, Guy M et al (2015) Prevalence of the HOXB13 G84E germline mutation in British men and correlation with prostate cancer risk, tumour characteristics and clinical outcomes. Ann Oncol 26(4):756–761 PubMed Kote-Jarai Z, Mikropoulos C, Leongamornlert DA, Dadaev T, Tymrakiewicz M, Saunders EJ, Jones M, Jugurnauth-Little S, Govindasami K, Guy M et al (2015) Prevalence of the HOXB13 G84E germline mutation in British men and correlation with prostate cancer risk, tumour characteristics and clinical outcomes. Ann Oncol 26(4):756–761 PubMed
47.
Zurück zum Zitat MacInnis RJ, Severi G, Baglietto L, Dowty JG, Jenkins MA, Southey MC, Hopper JL, Giles GG (2013) Population-based estimate of prostate cancer risk for carriers of the HOXB13 missense mutation G84E. PLoS ONE 8(2):e54727 PubMedPubMedCentral MacInnis RJ, Severi G, Baglietto L, Dowty JG, Jenkins MA, Southey MC, Hopper JL, Giles GG (2013) Population-based estimate of prostate cancer risk for carriers of the HOXB13 missense mutation G84E. PLoS ONE 8(2):e54727 PubMedPubMedCentral
48.
Zurück zum Zitat Storebjerg TM, Hoyer S, Kirkegaard P, Bro F, LuCamp Study G, Orntoft TF, Borre M, Sorensen KD (2016) Prevalence of the HOXB13 G84E mutation in Danish men undergoing radical prostatectomy and its correlations with prostate cancer risk and aggressiveness. BJU Int 118(4):646–653 PubMed Storebjerg TM, Hoyer S, Kirkegaard P, Bro F, LuCamp Study G, Orntoft TF, Borre M, Sorensen KD (2016) Prevalence of the HOXB13 G84E mutation in Danish men undergoing radical prostatectomy and its correlations with prostate cancer risk and aggressiveness. BJU Int 118(4):646–653 PubMed
49.
Zurück zum Zitat Beebe-Dimmer JL, Isaacs WB, Zuhlke KA, Yee C, Walsh PC, Isaacs SD, Johnson AM, Ewing CE, Humphreys EB, Chowdhury WH et al (2014) Prevalence of the HOXB13 G84E prostate cancer risk allele in men treated with radical prostatectomy. BJU Int 113(5):830–835 PubMedPubMedCentral Beebe-Dimmer JL, Isaacs WB, Zuhlke KA, Yee C, Walsh PC, Isaacs SD, Johnson AM, Ewing CE, Humphreys EB, Chowdhury WH et al (2014) Prevalence of the HOXB13 G84E prostate cancer risk allele in men treated with radical prostatectomy. BJU Int 113(5):830–835 PubMedPubMedCentral
50.
Zurück zum Zitat Leongamornlert D, Saunders E, Dadaev T, Tymrakiewicz M, Goh C, Jugurnauth-Little S, Kozarewa I, Fenwick K, Assiotis I, Barrowdale D et al (2014) Frequent germline deleterious mutations in DNA repair genes in familial prostate cancer cases are associated with advanced disease. Br J Cancer 110(6):1663–1672 PubMedPubMedCentral Leongamornlert D, Saunders E, Dadaev T, Tymrakiewicz M, Goh C, Jugurnauth-Little S, Kozarewa I, Fenwick K, Assiotis I, Barrowdale D et al (2014) Frequent germline deleterious mutations in DNA repair genes in familial prostate cancer cases are associated with advanced disease. Br J Cancer 110(6):1663–1672 PubMedPubMedCentral
51.
Zurück zum Zitat Na R, Zheng SL, Han M, Yu H, Jiang D, Shah S, Ewing CM, Zhang L, Novakovic K, Petkewicz J et al (2017) Germline mutations in ATM and BRCA1/2 distinguish risk for lethal and indolent prostate cancer and are associated with early age at death. Eur Urol 71(5):740–747 PubMed Na R, Zheng SL, Han M, Yu H, Jiang D, Shah S, Ewing CM, Zhang L, Novakovic K, Petkewicz J et al (2017) Germline mutations in ATM and BRCA1/2 distinguish risk for lethal and indolent prostate cancer and are associated with early age at death. Eur Urol 71(5):740–747 PubMed
Metadaten
Titel
Genetik des Prostatakarzinoms
verfasst von
Dr. David Schörghofer
Univ. Prof. Dr. Gökhan Uyanik
OÄ Dr. Katharina Rötzer
Publikationsdatum
17.07.2019
Verlag
Springer Vienna
Erschienen in
Journal für Urologie und Urogynäkologie/Österreich / Ausgabe 4/2019
Print ISSN: 1023-6090
Elektronische ISSN: 1680-9424
DOI
https://doi.org/10.1007/s41972-019-0077-z