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Erschienen in:

01.12.2021 | Review

Functional Characteristics and Application of Mesenchymal Stem Cells in Systemic Lupus Erythematosus

verfasst von: Wen-Yan Tang, Jia-Hua Liu, Chun-Jin Peng, Yao Liao, Jie-Si Luo, Xi Sun, Yan-Lai Tang, Xue-Qun Luo

Erschienen in: Archivum Immunologiae et Therapiae Experimentalis | Ausgabe 1/2021

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Abstract

Systemic lupus erythematosus (SLE) is a rare, heterogeneous autoimmune and autoinflammatory disease that affects both sexes and all races, although this disease exhibits its highest incidence/prevalence among the black population and shows a predilection for women of reproductive age. Although SLE has no cure, treatment can help decrease its signs and symptoms. Thus, we should focus primarily on personalized treatment. Mesenchymal stem/stromal cells (MSCs), which are multipotent cells capable of differentiating into osteoblasts, chondrocytes, adipocytes, and myoblasts, among other cell types, are potential candidates for use in a promising strategy to treat severe and refractory SLE. MSCs have an immunomodulatory function that can suppress the proliferation and activities of many immune cells, such as T lymphocytes, B lymphocytes, natural killer cells, macrophages and dendritic cells. Substantial progress has recently been made in MSC therapy, and experimental and clinical data suggest that such a therapy is a promising strategy for the treatment of severe and refractory SLE. In this review, we highlight the effects of MSCs on different immune cell types, describe the mechanisms underlying MSC-mediated immunoregulation, and discuss the treatment of SLE with MSCs from different sources in various animal models and clinical applications.
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Metadaten
Titel
Functional Characteristics and Application of Mesenchymal Stem Cells in Systemic Lupus Erythematosus
verfasst von
Wen-Yan Tang
Jia-Hua Liu
Chun-Jin Peng
Yao Liao
Jie-Si Luo
Xi Sun
Yan-Lai Tang
Xue-Qun Luo
Publikationsdatum
01.12.2021
Verlag
Springer International Publishing
Erschienen in
Archivum Immunologiae et Therapiae Experimentalis / Ausgabe 1/2021
Print ISSN: 0004-069X
Elektronische ISSN: 1661-4917
DOI
https://doi.org/10.1007/s00005-021-00603-y