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23.09.2022 | Originalien

Factors Affecting Female Infertility in the Population of Gujarat (India): A Comprehensive Study

verfasst von: Priyanka Sanghavi, Bhumika Savsaiya, Hitesh Patel, Kajal Patel, Divya Chandel

Erschienen in: Journal für Gynäkologische Endokrinologie/Österreich

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Abstract

Infertility affects 1 out of 6 couples of the world population and has multifactorial etiologies. The aim of the present study is to identify the correlation between some causative factors and female infertility. The detailed proforma with patient’s informed consent was filled out for total 120 females (42 control females and 78 case females, which included personal information, family history, lifestyle factors and serum hormone levels). Results showed that age, body mass index (BMI), previous history of miscarriage, and previous history of conception were significantly (p < 0.001) associated with female infertility. Similarly, independent t test results of clinical profile showed significant (p < 0.001) association of serum levels of follicle-stimulating hormone (FSH), luteinizing hormone (LH), prolactin (PRL), progesterone, and anti-Mullerian hormone (AMH). There was a non-significant association of lifestyle factors (alcohol consumption, smoking, diet, caffeine consumption, and menstrual cycle regularity) and family history of consanguineous marriage with female infertility. Also, we have found a nonsignificant association between female infertility and complaint of infertility in other family members of probands. The present study confirms that these factors are important aspects for determining the etiology of female infertility and will further help in the management of disease and provide essential treatment if required.
Literatur
1.
Zurück zum Zitat Olooto WE, Amballi AA, Banjo TA (2012) A review of female infertility; important etiological factors and management. J Microbiol Biotech Res 2(3):379–385 Olooto WE, Amballi AA, Banjo TA (2012) A review of female infertility; important etiological factors and management. J Microbiol Biotech Res 2(3):379–385
2.
Zurück zum Zitat Bhagavath B, Layman LC (2014) Genetics of female infertility in humans. Elsevier CrossRef Bhagavath B, Layman LC (2014) Genetics of female infertility in humans. Elsevier CrossRef
3.
Zurück zum Zitat Achermann JC, Jameson JL (1999) Fertility and infertility: genetic contributions from the hypothalamic-pituitary-gonadal axis. Mol Endocrinol 13(6):812–818 PubMedCrossRef Achermann JC, Jameson JL (1999) Fertility and infertility: genetic contributions from the hypothalamic-pituitary-gonadal axis. Mol Endocrinol 13(6):812–818 PubMedCrossRef
4.
Zurück zum Zitat Unuane D, Tournaye H, Velkeniers B, Poppe K (2011) Endocrine disorders & female infertility. Best Pract Res Clin Endocrinol Metab 25(6):861–873 PubMedCrossRef Unuane D, Tournaye H, Velkeniers B, Poppe K (2011) Endocrine disorders & female infertility. Best Pract Res Clin Endocrinol Metab 25(6):861–873 PubMedCrossRef
5.
Zurück zum Zitat Homan G, Davies M, Norman R (2007) The impact of lifestyle factors on reproductive performance in the general population and those undergoing infertility treatment: a review. Hum Reprod Update 13(3):209–223 PubMedCrossRef Homan G, Davies M, Norman R (2007) The impact of lifestyle factors on reproductive performance in the general population and those undergoing infertility treatment: a review. Hum Reprod Update 13(3):209–223 PubMedCrossRef
6.
Zurück zum Zitat Lucero J, Harlow BL, Barbieri RL, Sluss P, Cramer DW (2001) Early follicular phase hormone levels in relation to patterns of alcohol, tobacco, and coffee use. Fertil Steril 76(4):723–729 PubMedCrossRef Lucero J, Harlow BL, Barbieri RL, Sluss P, Cramer DW (2001) Early follicular phase hormone levels in relation to patterns of alcohol, tobacco, and coffee use. Fertil Steril 76(4):723–729 PubMedCrossRef
7.
Zurück zum Zitat Te Velde ER, Pearson PL (2002) The variability of female reproductive age. Hum Reprod Update 8(2):141–154 CrossRef Te Velde ER, Pearson PL (2002) The variability of female reproductive age. Hum Reprod Update 8(2):141–154 CrossRef
8.
Zurück zum Zitat ESHRE Capri Workshop Group (2005) Fertility and ageing. Hum Reprod Update 11(3):261–276 CrossRef ESHRE Capri Workshop Group (2005) Fertility and ageing. Hum Reprod Update 11(3):261–276 CrossRef
9.
Zurück zum Zitat Brugo-Olmedo S, Chillik C, Kopelman S (2001) Definition and causes of infertility. Reprod Biomed Online 2(1):173–185 CrossRef Brugo-Olmedo S, Chillik C, Kopelman S (2001) Definition and causes of infertility. Reprod Biomed Online 2(1):173–185 CrossRef
10.
Zurück zum Zitat Gougeon A (2005) The biological aspects of risks of infertility due to age: the female side. Rev Epidemiol Sante Publique 53:37–45 CrossRef Gougeon A (2005) The biological aspects of risks of infertility due to age: the female side. Rev Epidemiol Sante Publique 53:37–45 CrossRef
11.
Zurück zum Zitat Maheshwari A, Hamilton M, Bhattacharya S (2008) Effect of female age on the diagnostic categories of infertility. Hum Reprod 23(3):538–542 PubMedCrossRef Maheshwari A, Hamilton M, Bhattacharya S (2008) Effect of female age on the diagnostic categories of infertility. Hum Reprod 23(3):538–542 PubMedCrossRef
12.
Zurück zum Zitat Fedorcsák P, Dale PO, Storeng R et al (2004) Impact of overweight and underweight on assisted reproduction treatment. Hum Reprod 19(11):2523–2528 PubMedCrossRef Fedorcsák P, Dale PO, Storeng R et al (2004) Impact of overweight and underweight on assisted reproduction treatment. Hum Reprod 19(11):2523–2528 PubMedCrossRef
13.
Zurück zum Zitat Hassan MA, Killick SR (2004) Negative lifestyle is associated with a significant reduction in fecundity. Fertil Steril 81(2):384–392 PubMedCrossRef Hassan MA, Killick SR (2004) Negative lifestyle is associated with a significant reduction in fecundity. Fertil Steril 81(2):384–392 PubMedCrossRef
14.
Zurück zum Zitat Parihar M (2003) Obesity and infertility. Rev Gynaecol Pract 3(3):120–126 CrossRef Parihar M (2003) Obesity and infertility. Rev Gynaecol Pract 3(3):120–126 CrossRef
15.
Zurück zum Zitat Dağ ZÖ, Dilbaz B (2015) Impact of obesity on infertility in women. J Turkish German Gynecol Assoc 16(2):111 CrossRef Dağ ZÖ, Dilbaz B (2015) Impact of obesity on infertility in women. J Turkish German Gynecol Assoc 16(2):111 CrossRef
16.
Zurück zum Zitat Agenor A, Bhattacharya S (2015) Infertility and miscarriage: common pathways in manifestation and management. Womens Health 11(4):527–541 Agenor A, Bhattacharya S (2015) Infertility and miscarriage: common pathways in manifestation and management. Womens Health 11(4):527–541
17.
Zurück zum Zitat Shamila S, Sasikala SL (2011) Primary report on the risk factors affecting female infertility in South Indian districts of Tamil Nadu and Kerala. Indian J Community Med 36:59–61 PubMedPubMedCentralCrossRef Shamila S, Sasikala SL (2011) Primary report on the risk factors affecting female infertility in South Indian districts of Tamil Nadu and Kerala. Indian J Community Med 36:59–61 PubMedPubMedCentralCrossRef
18.
Zurück zum Zitat Udgiri R, Patil VV (2019) Comparative study to determine the prevalence and socio-cultural practices of infertility in rural and urban field practice area of tertiary care hospital, Vijayapura, Karnataka. Indian J Community Med 44(2):129 PubMedPubMedCentral Udgiri R, Patil VV (2019) Comparative study to determine the prevalence and socio-cultural practices of infertility in rural and urban field practice area of tertiary care hospital, Vijayapura, Karnataka. Indian J Community Med 44(2):129 PubMedPubMedCentral
19.
Zurück zum Zitat Vander Borght M, Wyns C (2018) Fertility and infertility: definition and epidemiology. Clin Biochem 62:2–10 PubMedCrossRef Vander Borght M, Wyns C (2018) Fertility and infertility: definition and epidemiology. Clin Biochem 62:2–10 PubMedCrossRef
20.
Zurück zum Zitat Seher T, Thiering E, Al Azemi M et al (2015) Is parental consanguinity associated with reduced ovarian reserve? Reprod Biomed Online 31(3):427–433 PubMedCrossRef Seher T, Thiering E, Al Azemi M et al (2015) Is parental consanguinity associated with reduced ovarian reserve? Reprod Biomed Online 31(3):427–433 PubMedCrossRef
21.
Zurück zum Zitat Clark AM, Thornley B, Tomlinson L et al (1998) Weight loss in obese infertile women results in improvement in reproductive outcome for all forms of fertility treatment. Hum Reprod 13(6):1502–1505 PubMedCrossRef Clark AM, Thornley B, Tomlinson L et al (1998) Weight loss in obese infertile women results in improvement in reproductive outcome for all forms of fertility treatment. Hum Reprod 13(6):1502–1505 PubMedCrossRef
22.
Zurück zum Zitat Direkvand-Moghadam A, Delpisheh A, Khosravi A (2013) Epidemiology of female infertility; a review of literature. Biosci Biotechnol Res Asia 10(2):559–567 CrossRef Direkvand-Moghadam A, Delpisheh A, Khosravi A (2013) Epidemiology of female infertility; a review of literature. Biosci Biotechnol Res Asia 10(2):559–567 CrossRef
23.
Zurück zum Zitat Dhanashree N, Anuradha S, Ketan S (2016) Effect of diet and nutrient intake on women who have problems of fertility. Int J Pure App Biosci 4(4):198–204 CrossRef Dhanashree N, Anuradha S, Ketan S (2016) Effect of diet and nutrient intake on women who have problems of fertility. Int J Pure App Biosci 4(4):198–204 CrossRef
24.
Zurück zum Zitat Vujkovic M, de Vries JH, Lindemans J et al (2010) The preconception Mediterranean dietary pattern in couples undergoing in vitro fertilization/intracytoplasmic sperm injection treatment increase the chance of pregnancy. Fertil Steril 94(6):2096–2101 PubMedCrossRef Vujkovic M, de Vries JH, Lindemans J et al (2010) The preconception Mediterranean dietary pattern in couples undergoing in vitro fertilization/intracytoplasmic sperm injection treatment increase the chance of pregnancy. Fertil Steril 94(6):2096–2101 PubMedCrossRef
25.
Zurück zum Zitat Eggert J, Theobald H, Engfeldt P (2004) Effects of alcohol consumption on female fertility during an 18-year period. Fertil Steril 81(2):379–383 PubMedCrossRef Eggert J, Theobald H, Engfeldt P (2004) Effects of alcohol consumption on female fertility during an 18-year period. Fertil Steril 81(2):379–383 PubMedCrossRef
26.
Zurück zum Zitat Tolstrup JS, Kjær SK, Munk C et al (2003) Does caffeine and alcohol intake before pregnancy predict the occurrence of spontaneous abortion? Hum Reprod 18(12):2704–2710 PubMedCrossRef Tolstrup JS, Kjær SK, Munk C et al (2003) Does caffeine and alcohol intake before pregnancy predict the occurrence of spontaneous abortion? Hum Reprod 18(12):2704–2710 PubMedCrossRef
27.
Zurück zum Zitat Augood C, Duckitt K, Templeton AA (1998) Smoking and female infertility: a systematic review and meta-analysis. Hum Reprod 13(6):1532–1539 PubMedCrossRef Augood C, Duckitt K, Templeton AA (1998) Smoking and female infertility: a systematic review and meta-analysis. Hum Reprod 13(6):1532–1539 PubMedCrossRef
28.
Zurück zum Zitat Klonoff-Cohen H (2005) Female and male lifestyle habits and IVF: what is known and unknown. Hum Reprod Update 11(2):180–204 CrossRef Klonoff-Cohen H (2005) Female and male lifestyle habits and IVF: what is known and unknown. Hum Reprod Update 11(2):180–204 CrossRef
29.
Zurück zum Zitat Younglai EV, Holloway AC, Foster WG (2005) Environmental and occupational factors affecting fertility and IVF success. Hum Reprod Update 11(1):43–57 PubMedCrossRef Younglai EV, Holloway AC, Foster WG (2005) Environmental and occupational factors affecting fertility and IVF success. Hum Reprod Update 11(1):43–57 PubMedCrossRef
30.
Zurück zum Zitat Roth LK, Taylor HS (2001) Risks of smoking to reproductive health: assessment of women’s knowledge. Am J Obstet Gynecol 184(5):934–939 PubMedCrossRef Roth LK, Taylor HS (2001) Risks of smoking to reproductive health: assessment of women’s knowledge. Am J Obstet Gynecol 184(5):934–939 PubMedCrossRef
31.
Zurück zum Zitat Shiloh H, Baratz SL, Koifman M et al (2004) The impact of cigarette smoking on zona pellucida thickness of oocytes and embryos prior to transfer into the uterine cavity. Hum Reprod 19(1):157–159 PubMedCrossRef Shiloh H, Baratz SL, Koifman M et al (2004) The impact of cigarette smoking on zona pellucida thickness of oocytes and embryos prior to transfer into the uterine cavity. Hum Reprod 19(1):157–159 PubMedCrossRef
32.
Zurück zum Zitat Hakim RB, Gray RH, Zacur H (1998) Alcohol and caffeine consumption and decreased fertility. Fertil Steril 70(4):632–637 PubMedCrossRef Hakim RB, Gray RH, Zacur H (1998) Alcohol and caffeine consumption and decreased fertility. Fertil Steril 70(4):632–637 PubMedCrossRef
33.
Zurück zum Zitat Howles CM (2000) Role of LH and FSH in ovarian function. Mol Cell Endocrinol 161(1–2):25–30 PubMedCrossRef Howles CM (2000) Role of LH and FSH in ovarian function. Mol Cell Endocrinol 161(1–2):25–30 PubMedCrossRef
34.
Zurück zum Zitat Odiba AS, Joshua PE, Ukegbu CY, Onosakponome I (2014) Evaluation of the quantitative expression and correlation between follicle stimulating hormone (FSH) and luteinizing hormone (LH) during follicular phase in primary infertile women of reproductive age. J Dent Med Sci 13(1):60–65 Odiba AS, Joshua PE, Ukegbu CY, Onosakponome I (2014) Evaluation of the quantitative expression and correlation between follicle stimulating hormone (FSH) and luteinizing hormone (LH) during follicular phase in primary infertile women of reproductive age. J Dent Med Sci 13(1):60–65
35.
Zurück zum Zitat Prasad B, Parmar D, Sharma N (2015) A study on serum FSH, LH and prolactin levels among infertile women. Int J Med Res Health Sci 4(4):876–878 Prasad B, Parmar D, Sharma N (2015) A study on serum FSH, LH and prolactin levels among infertile women. Int J Med Res Health Sci 4(4):876–878
36.
Zurück zum Zitat Olooto WE, Adeleye AO, Amballi AA, Mosuro AO (2012) Pattern of reproductive hormones (follicle stimulating hormone, luteinizing hormone, estradiol, progesterone, and prolactin) levels in infertile women in Sagamu South Western Nigeria. Pharm Lettre 4(2):549–553 Olooto WE, Adeleye AO, Amballi AA, Mosuro AO (2012) Pattern of reproductive hormones (follicle stimulating hormone, luteinizing hormone, estradiol, progesterone, and prolactin) levels in infertile women in Sagamu South Western Nigeria. Pharm Lettre 4(2):549–553
37.
Zurück zum Zitat Mishra R, Baveja R, Gupta V, Gupta P (2002) Prolactin level in infertility with menstrual irregularities. J Obstet Gynecol India 52(6):40–43 Mishra R, Baveja R, Gupta V, Gupta P (2002) Prolactin level in infertility with menstrual irregularities. J Obstet Gynecol India 52(6):40–43
38.
Zurück zum Zitat Golden NH, Carlson JL (2008) The pathophysiology of amenorrhea in the adolescent. Ann NY Acad Sci 1135(1):163–178 PubMedCrossRef Golden NH, Carlson JL (2008) The pathophysiology of amenorrhea in the adolescent. Ann NY Acad Sci 1135(1):163–178 PubMedCrossRef
39.
Zurück zum Zitat Goswami B, Patel S, Chatterjee M et al (2009) Correlation of prolactin and thyroid hormone concentration with menstrual patterns in infertile women. J Reprod Infertil 10(3):207 PubMedCentral Goswami B, Patel S, Chatterjee M et al (2009) Correlation of prolactin and thyroid hormone concentration with menstrual patterns in infertile women. J Reprod Infertil 10(3):207 PubMedCentral
40.
Zurück zum Zitat Luciano AA, Lanzone A, Goverde AJ (2013) Management of female infertility from hormonal causes. Int J Gynecol Obstet 123:S9–S17 CrossRef Luciano AA, Lanzone A, Goverde AJ (2013) Management of female infertility from hormonal causes. Int J Gynecol Obstet 123:S9–S17 CrossRef
41.
Zurück zum Zitat Turankar S, Sonone K, Turankar A (2013) Hyperprolactinaemia and its comparision with hypothyroidism in primary infertile women. J Clin Diagn Res 7(5):794 PubMedPubMedCentral Turankar S, Sonone K, Turankar A (2013) Hyperprolactinaemia and its comparision with hypothyroidism in primary infertile women. J Clin Diagn Res 7(5):794 PubMedPubMedCentral
42.
Zurück zum Zitat Seth B, Arora S, Singh R (2013) Association of obesity with hormonal imbalance in infertility: a cross-sectional study in north Indian women. Ind J Clin Biochem 28(4):342–347 CrossRef Seth B, Arora S, Singh R (2013) Association of obesity with hormonal imbalance in infertility: a cross-sectional study in north Indian women. Ind J Clin Biochem 28(4):342–347 CrossRef
43.
Zurück zum Zitat Lal RZ, Biyani S, Lodha R (2016) Correlation of thyroid hormones with FSH, LH and prolactin in infertility in the reproductive age group women. Int Arch Integr Med 3(5):146–150 Lal RZ, Biyani S, Lodha R (2016) Correlation of thyroid hormones with FSH, LH and prolactin in infertility in the reproductive age group women. Int Arch Integr Med 3(5):146–150
44.
Zurück zum Zitat Sanchez E, Giviziez CR, Sanchez HM et al (2015) Low progesterone levels and ovulation by ultrasound assessment in infertile patients. JBRA Assist Reprod 20(1):13–16 Sanchez E, Giviziez CR, Sanchez HM et al (2015) Low progesterone levels and ovulation by ultrasound assessment in infertile patients. JBRA Assist Reprod 20(1):13–16
45.
Zurück zum Zitat Saleh BO, Ibraheem WF, Ameen NS (2015) The role of anti-Mullerian hormone and inhibin B in the assessment of metformin therapy in women with polycystic ovarian syndrome. SMJ 36(5):562 CrossRef Saleh BO, Ibraheem WF, Ameen NS (2015) The role of anti-Mullerian hormone and inhibin B in the assessment of metformin therapy in women with polycystic ovarian syndrome. SMJ 36(5):562 CrossRef
46.
Zurück zum Zitat Lata I, Tiwari S, Gupta A et al (2017) To study the Vitamin D levels in infertile females and correlation of Vitamin D deficiency with AMH levels in comparison to fertile females. J Hum Reprod Sci 10(2):86 PubMedPubMedCentralCrossRef Lata I, Tiwari S, Gupta A et al (2017) To study the Vitamin D levels in infertile females and correlation of Vitamin D deficiency with AMH levels in comparison to fertile females. J Hum Reprod Sci 10(2):86 PubMedPubMedCentralCrossRef
Metadaten
Titel
Factors Affecting Female Infertility in the Population of Gujarat (India): A Comprehensive Study
verfasst von
Priyanka Sanghavi
Bhumika Savsaiya
Hitesh Patel
Kajal Patel
Divya Chandel
Publikationsdatum
23.09.2022
Verlag
Springer Vienna
Erschienen in
Journal für Gynäkologische Endokrinologie/Österreich
Print ISSN: 1997-6690
Elektronische ISSN: 1996-1553
DOI
https://doi.org/10.1007/s41974-022-00240-z