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Erschienen in: Wiener klinische Wochenschrift 21-22/2021

31.08.2021 | original article

Expression profiles of miR-196, miR-132, miR-146a, and miR-134 in human colorectal cancer tissues in accordance with their clinical significance

Comparison regarding KRAS mutation

verfasst von: Mahafarin Maralani, Dariush Shanehbandi, Milad Asadi, Shahriar Hashemzadeh, Khalil Hajiasgharzadeh, Hossein Mashhadi Abdolahi, Behzad Baradaran, Marc Peeters

Erschienen in: Wiener klinische Wochenschrift | Ausgabe 21-22/2021

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Summary

Background

Colorectal cancer (CRC) is among the most widespread malignancies in the world. MicroRNA (miRNA) has been identified as an important modulator of the biological processes of the cells. This group of noncoding RNAs also has a pivotal function in the growth and development of human cancers, including CRC. Among these miRNAs, miR-196, miR-132, miR-146a, and miR-134 have fundamental impacts on the regulation of cancers. The current study aimed to investigate the involvement of these miRNAs in CRC patients.

Methods

In this study, 50 pairs of tumor and tumor margin samples of CRC patients were investigated to assess the expression levels of miR-196, miR-132, miR-146a, and miR-134 in this cancer. For this purpose, firstly, quantitative real-time PCR (qRT-PCR) was applied. Also, KRAS mutation and clinicopathological characteristics of the CRC patients were analyzed in the study groups.

Results

The findings demonstrated the overexpression of miR-196 (P-value = 0.0045) and miR-146a (P-value = 0.0033) in tumor tissues compared to controls. Conversely, the expression levels of miR-132 (P-value = 0.00032) and miR-134 (P-value < 0.0001) were downregulated in tumor tissues. Also, miR-146a was the only miRNA with significant expression change in the case of the KRAS gene mutation. Interestingly, the expression ratio of these miRNAs was significantly associated with some of the clinicopathological features of the patients, such as lymph node and distant metastases.

Conclusion

Our data demonstrated that these miRNAs appear to be promising novel biomarkers for early diagnosis of CRC and may pave the way for the future establishment of novel therapeutic options for CRC.

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Metadaten
Titel
Expression profiles of miR-196, miR-132, miR-146a, and miR-134 in human colorectal cancer tissues in accordance with their clinical significance
Comparison regarding KRAS mutation
verfasst von
Mahafarin Maralani
Dariush Shanehbandi
Milad Asadi
Shahriar Hashemzadeh
Khalil Hajiasgharzadeh
Hossein Mashhadi Abdolahi
Behzad Baradaran
Marc Peeters
Publikationsdatum
31.08.2021
Verlag
Springer Vienna
Erschienen in
Wiener klinische Wochenschrift / Ausgabe 21-22/2021
Print ISSN: 0043-5325
Elektronische ISSN: 1613-7671
DOI
https://doi.org/10.1007/s00508-021-01933-9