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01.11.2014 | main topic | Ausgabe 21-22/2014

Wiener Medizinische Wochenschrift 21-22/2014

Expression and putative functions of melatonin receptors in malignant cells and tissues

Zeitschrift:
Wiener Medizinische Wochenschrift > Ausgabe 21-22/2014
Autor:
Cem Ekmekcioglu

Summary

Melatonin, the popular hormone of the darkness, is primarily synthesized in the pineal gland, and acts classically through the G-protein coupled plasma membrane melatonin receptors MT1 and MT2, respectively. Although some of the receptor mediated functions of melatonin, especially those on the (central) circadian system, have been more or less clarified, the functional meaning of MT-receptors in various peripheral organs are still not sufficiently investigated yet. There is, however, accumulating evidence for oncostatic effects of melatonin with both, antioxidative and MT-receptor mediated mechanisms possibly playing a role. This review briefly summarizes the physiology of melatonin and MT-receptors, and discusses the expression and function of MT-receptors in human cancer cells and tissues.

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