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Excellent response of a disseminated SMARCA4-deficient thoracic sarcomatoid tumor to immunochemotherapy—a case report

verfasst von: Clemens Petrasch, MD, Simon Udovica, MD, Frédéric Witte, MD, Bernadette Liegl-Atzwanger, MD, Wolfgang Pokieser, MD, Siroos Mirzaei, MD, Wolfgang Hilbe, MD, Andrea Kaufmann-Keck, MD

Erschienen in: memo - Magazine of European Medical Oncology | Ausgabe 2/2023

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Summary

A 68-year-old man was diagnosed with a SMARCA4-deficient thoracic sarcomatoid tumor. Immunochemotherapy with carboplatin, paclitaxel, and pembrolizumab followed by maintenance therapy with pembrolizumab resulted in clinically meaningful remission.

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Concepcion CP, Ma S, LaFave LM, Bhutkar A, Liu M, DeAngelo LP, Kim JY, Del Priore I, Schoenfeld AJ, Miller M, Kartha VK, Westcott PMK, Sánchez-Rivera FJ, Meli K, Gupta M, Bronson RT, Riely GJ, Rekhtman N, Rudin CM, Kim CF, Regev A, Buenrostro JD, Jacks T. Smarca4 inactivation promotes lineage-specific transformation and early metastatic features in the lung. Cancer Discov. 2022;12(2):562–85. https://doi.org/10.1158/2159-8290.CD-21-0248. CrossRefPubMed

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Schoenfeld AJ, Bandlamudi C, Lavery JA, Montecalvo J, Namakydoust A, Rizvi H, Egger J, Concepcion CP, Paul S, Arcila ME, Daneshbod Y, Chang J, Sauter JL, Beras A, Ladanyi M, Jacks T, Rudin CM, Taylor BS, Donoghue MTA, Heller G, Hellmann MD, Rekhtman N, Riely GJ. The genomic landscape of SMARCA4 alterations and associations with outcomes in patients with lung cancer. Clin Cancer Res. 2020;26(21):5701–8. https://doi.org/10.1158/1078-0432.CCR-20-1825. CrossRefPubMedPubMedCentral

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Titel: Excellent response of a disseminated SMARCA4-deficient thoracic sarcomatoid tumor to immunochemotherapy—a case report
verfasst von: Clemens Petrasch, MD
Simon Udovica, MD
Frédéric Witte, MD
Bernadette Liegl-Atzwanger, MD
Wolfgang Pokieser, MD
Siroos Mirzaei, MD
Wolfgang Hilbe, MD
Andrea Kaufmann-Keck, MD
Publikationsdatum: 20.04.2023
Verlag: Springer Vienna
Erschienen in: memo - Magazine of European Medical Oncology / Ausgabe 2/2023
Print ISSN: 1865-5041
Elektronische ISSN: 1865-5076
DOI: https://doi.org/10.1007/s12254-023-00880-7

Springer Medizin Österreich

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Excellent response of a disseminated SMARCA4-deficient thoracic sarcomatoid tumor to immunochemotherapy—a case report

Summary

Springer Medizin Österreich

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Weitere Artikel dieser Ausgabe durch Wischen aufrufen

Summary

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