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01.06.2012 | review | Ausgabe 2/2012

memo - Magazine of European Medical Oncology 2/2012

Evolving strategies to overcome endocrine resistance in breast cancer

Zeitschrift:
memo - Magazine of European Medical Oncology > Ausgabe 2/2012
Autoren:
M.D. Michael Hubalek, M.D. Christine Brunner, M.D. Christian Marth

Abstract

Endocrine therapies targeting estrogen action decrease mortality from breast cancer, but their efficacy is limited by intrinsic and acquired therapeutic resistance. Various mechanisms can contribute to insensitivity toward endocrine treatment in hormone receptor-positive breast cancer patients. Definition of the specific genetic lesions and molecular processes that determine clinical endocrine resistance is still incomplete but recently tremendous advances have been made. In this short review the latest strategies to overcome endocrine resistance will be discussed.

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