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01.11.2015 | original article | Ausgabe 21-22/2015

Wiener klinische Wochenschrift 21-22/2015

Evaluation of electrocardiographic parameters in patients with diabetes insipidus

Zeitschrift:
Wiener klinische Wochenschrift > Ausgabe 21-22/2015
Autoren:
Assoc. Prof. Ferhat Deniz, Assoc. Prof. Alper Kepez, MD Seyit Ahmet Ay, Prof. Okan Ergogan, MD Kamil Baskoy, Mustafa Nuri Guncıkan, MD Zekeriya Dogan, Assoc. Prof. Arif Yonem

Summary

Background

There is limited data regarding the effect of altered serum osmolality on cardiac electrical activity. The aim of the present study is to evaluate the electrocardiographic (ECG) effects of diabetes insipidus (DI) and any related hyperosmolality in a population of young patients with DI and without any known cardiovascular disease or risk factors.

Methods

Twelve-lead ECG’s of 44 consecutive untreated young male patients (age: 21.8 ± 2.9 years) who had been referred to endocrinology clinic and diagnosed as DI based on water deprivation test were retrospectively evaluated. A total of 30 age-matched (21.9 ± 2.4 years) healthy males were selected as control group and ECG’s of these controls were obtained for comparison with ECG’s of DI patients. All ECG parameters were measured and compared.

Results

Duration of QRS complex was significantly shorter in patients with DI compared with controls (85.2 ± 12.0 vs. 94.0 ± 10.6 ms, p: 0.001). P wave dispersion (PWD) of patients with DI was significantly higher compared with controls (31.9 ± 9.9 vs. 26.5 ± 10.6 ms, p: 0.03) and it was significantly correlated with serum osmolality and serum sodium level (r = − 0.36, p: 0.02 and r: − 0.35, p: 0.02, respectively).

Conclusions

DI patients without any cardiovascular disease or risk factors displayed significantly shorter QRS duration and increased p wave dispersion compared with controls.

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