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01.02.2017 | main topic | Ausgabe 1-2/2017 Open Access

Wiener Medizinische Wochenschrift 1-2/2017

Epidemiology and pathology of Paget’s disease of bone – a review

Wiener Medizinische Wochenschrift > Ausgabe 1-2/2017
PhD Elena Nebot Valenzuela, Peter Pietschmann


Paget’s disease of bone (PDB) is a noninflammatory, metabolic, skeletal disorder characterized by localized excessive osteoclastic bone resorption that is followed by compensatory increased osteoblastic activity leading to unstructured, fibroblastic, and biomechanically unstable bone. As a result, there is deformity and enlargement of the bone with a defective and disorganized pattern. Here, we review the epidemiology, etiology, pathology, macrostructure, histology, and quantitative histomorphometry findings of PDB. Hyperosteoclastosis and poor definition of the boundary between cortical and medullary bone are the main histological findings in PDB. Additionally, Pagetic bone is also characterized by hypertrophy and alteration of trabecular parameters.

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