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20.02.2020 | special report | Ausgabe 1/2020 Open Access

memo - Magazine of European Medical Oncology 1/2020

Ensuring center quality, proper patient selection and fair access to chimeric antigen receptor T-cell therapy: position statement of the Austrian CAR-T Cell Network

Zeitschrift:
memo - Magazine of European Medical Oncology > Ausgabe 1/2020
Autoren:
Univ. Prof. Dr. Hildegard T. Greinix, Univ. Prof. Dr. Andishe Attarbaschi, Dr. Michael Girschikofsky, Univ. Prof. Dr. Richard Greil, Univ. Prof. Dr. Wolfgang Holter, Univ. Prof. Dr. Peter Neumeister, Univ. Prof. Dr. Christina Peters, Univ. Prof. Dr. Andreas Petzer, Dr. Jakob Rudzki, Univ. Prof. Dr. Peter Schlenke, Univ. Prof. Dr. Clemens A. Schmitt, Univ. Prof. Dr. Wolfgang Schwinger, Univ. Prof. Dr. Dominik Wolf, Univ. Prof. Dr. Nina Worel, Univ. Prof. Dr. Ulrich Jaeger
Wichtige Hinweise

Electronic supplementary material

The online version of this article (https://​doi.​org/​10.​1007/​s12254-020-00582-4) contains supplementary material, which is available to authorized users.
All authors contributed equally to this work.
This position paper has been endorsed by the Austrian Society of Hematology and Medical Oncology (OEGHO).

Publisher’s Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Summary

Chimeric antigen receptor T cells (CAR-T cells) are a novel form of cellular immunotherapy for patients with hematologic and oncologic malignancies. Known side effects of these approved cellular immunotherapies are cytokine release syndrome, immune-cell associated neurotoxicity syndrome, cytopenias, infections and long-lasting B cell aplasia. Safe administration of CAR-T cell therapy requires thorough patient selection and patient care in qualified CAR-T cell centers.

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