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Erschienen in: Wiener klinische Wochenschrift 15-16/2017

01.08.2017 | original article

Early detection of lung function decrements in children and adolescents with cystic fibrosis using new reference values

verfasst von: Priv. Doz. Dr. Angela Zacharasiewicz, Sabine Renner, Flora Haderer, Michael Weber, Eleonore Dehlink, Zsolt Szepfalusi, Thomas Frischer

Erschienen in: Wiener klinische Wochenschrift | Ausgabe 15-16/2017

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Summary

Interpretation of lung function values in children with cystic fibrosis (CF) depends on the applied reference values. We hypothesize that differences between the new global lung function initiative (GLI) values and the formerly used Zapletal et al. values produce significantly different clinical results. We analyzed 3719 lung function measurements of 108 children and adolescents (n = 54 male; aged 6–18 years) with CF treated between September 1991 and July 2009. Data were analyzed in milliliters (ml) and % predicted (pred.) and interpreted using Zapletal and GLI reference values. Applying GLI compared to Zapletal resulted in significantly lower mean forced expiratory volume in 1s (FEV1)% pred. values: Zapletal 86.6% (SD 20.6), GLI 79.9% (SD 20.3) and 32% (n = 497/1543) were misclassified as normal when using Zapletal. Despite showing no overall differences in FEV1 and forced vital capacity (FVC) between concomitant Pseudomonas detection (PA+) in n = 938 and Pseudomonas negative (PA-) (n = 2781) using either reference PA+ resulted in lower FEV1 and FVC values with increasing age; however, measurement of small airway obstruction with forced expiratory flow at 75% of FVC (FEF75) values – available for Zapletal –showed significant differences. Reassurance regarding lung function when using old reference values may occur with potential clinical significance. Discrepancies in lung function interpretation underline the importance of using uniform and best available reference values.

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Metadaten
Titel
Early detection of lung function decrements in children and adolescents with cystic fibrosis using new reference values
verfasst von
Priv. Doz. Dr. Angela Zacharasiewicz
Sabine Renner
Flora Haderer
Michael Weber
Eleonore Dehlink
Zsolt Szepfalusi
Thomas Frischer
Publikationsdatum
01.08.2017
Verlag
Springer Vienna
Erschienen in
Wiener klinische Wochenschrift / Ausgabe 15-16/2017
Print ISSN: 0043-5325
Elektronische ISSN: 1613-7671
DOI
https://doi.org/10.1007/s00508-017-1184-0