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Erschienen in: Wiener klinische Wochenschrift 21-22/2013

01.11.2013 | original article

Differences in the metabolic status of healthy adults with and without active brown adipose tissue

verfasst von: Qiongyue Zhang, Hongying Ye, Qing Miao, Zhaoyun Zhang, Yi Wang, Xiaoming Zhu, Shuo Zhang, Chuantao Zuo, Zhengwei Zhang, Zhemin Huang, Ruidan Xue, Meifang Zeng, Haiyan Huang, Wanzhu Jin, Qiqun Tang, Yihui Guan, Yiming Li

Erschienen in: Wiener klinische Wochenschrift | Ausgabe 21-22/2013

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Summary

Background

Previous studies have proven the existence of active brown adipose tissue (BAT) in adults; however, its effect on systematic metabolism remains unclear.

Aim

The current study was designed to investigate the differences in the metabolic profiles of healthy adults with and without active BAT using positron emission tomography–computed tomography (PET-CT) scans in the un-stimulated state.

Methods

A cross-sectional analysis was performed to assess the health of adults using PET-CT whole-body scans at Huashan Hospital Medical Centre between November 2009 and May 2010. A total of 62 healthy adults with active BAT were enrolled in the BAT-positive group. For each positive subject, a same-gender individual who underwent PET-CT the same day and who had no detectable BAT was chosen as the negative control. Body composition was measured, and blood samples were collected for assays of metabolic profiles and other biomarkers.

Results

In both the male and female groups, BAT-positive individuals were younger and had lower body mass indexes, fasting insulin, insulin resistance, and leptin, but a greater level of high-density lipoprotein cholesterol compared with the negative controls. In the male group, body fat content and levels of tumor necrosis factor-α were significantly lower in the BAT-positive than in the negative control group.

Conclusions

The healthy adults with active BAT in an un-stimulated state had favorable metabolic profiles suggesting that active BAT may be a potential target for preventing and treating obesity and other metabolic disorders.

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Metadaten
Titel
Differences in the metabolic status of healthy adults with and without active brown adipose tissue
verfasst von
Qiongyue Zhang
Hongying Ye
Qing Miao
Zhaoyun Zhang
Yi Wang
Xiaoming Zhu
Shuo Zhang
Chuantao Zuo
Zhengwei Zhang
Zhemin Huang
Ruidan Xue
Meifang Zeng
Haiyan Huang
Wanzhu Jin
Qiqun Tang
Yihui Guan
Yiming Li
Publikationsdatum
01.11.2013
Verlag
Springer Vienna
Erschienen in
Wiener klinische Wochenschrift / Ausgabe 21-22/2013
Print ISSN: 0043-5325
Elektronische ISSN: 1613-7671
DOI
https://doi.org/10.1007/s00508-013-0431-2