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Diagnostic accuracy of the ¹⁴C-urea breath test in Helicobacter pylori infections: a meta-analysis

Zeitschrift:: Wiener klinische Wochenschrift > Ausgabe 1-2/2017

Autoren:: Qiaohui Zhou, Ling Li, Yaowei Ai, Zhihong Pan, Mingwen Guo, MD Jingbo Han

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Summary

Objectives

To summarize and appraise the available literature regarding the use of the ¹⁴C-urea breath test in the diagnosis of Helicobacter pylori infections in adult patients with dyspepsia and to calculate pooled diagnostic accuracy measures.

Methods

We systematically searched the PubMed, EMBASE, Cochrane Library, Chinese Journals Full-text (CNKI) and CBMDisc databases to identify published data regarding the sensitivity, specificity, and other measures of diagnostic accuracy of the ¹⁴C-urea breath test in the diagnosis of Helicobacter pylori infections in adult patients with dyspeptic symptoms. Risk of bias was assessed using the QUADAS (Quality Assessment of Diagnostic Accuracy Studies)-2 tool. Statistical analyses were performed using Meta-Disc 1.4 software and STATA.

Results

Eighteen studies met the inclusion criteria. Pooled results indicated that the ¹⁴C-urea breath test showed a diagnostic sensitivity of 0.96 (95% CI 0.95 to 0.96) and specificity of 0.93 (95% CI 0.91 to 0.94). The positive like ratio (PLR) was 12.27 (95% CI 8.17 to 18.44), the negative like ratio (NLR) was 0.05 (95% CI 0.04 to 0.07), and the area under the curve was 0.985. The DOR was 294.95 (95% CI 178.37 to 487.70). The ¹⁴C-urea breath test showed sufficient sensitivity and specificity for diagnosing Helicobacter pylori infection, but unexplained heterogeneity after meta-regression and several subgroup analyses remained.

Conclusions

The UBT has high accuracy for diagnosing H. pylori infections in adult patients with dyspepsia. However, the reliability of these diagnostic meta-analytic estimates is limited by significant heterogeneity due to unknown factors.

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Titel: Diagnostic accuracy of the 14C-urea breath test in Helicobacter pylori infections: a meta-analysis
Autoren:: Qiaohui Zhou
Ling Li
Yaowei Ai
Zhihong Pan
Mingwen Guo
MD Jingbo Han
Publikationsdatum: 01.01.2017
DOI: https://doi.org/10.1007/s00508-016-1117-3
Verlag: Springer Vienna
Zeitschrift: Wiener klinische Wochenschrift The Central European Journal of Medicine
Ausgabe 1-2/2017
Print ISSN: 0043-5325
Elektronische ISSN: 1613-7671

Springer Medizin Österreich

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Summary

Objectives

Methods

Results

Conclusions

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