Skip to main content
Registrieren
Springer Medizin Österreich
SUCHE
MENÜ 1 2 3 4
main-content
nach oben

Tipp

Weitere Artikel dieser Ausgabe durch Wischen aufrufen

Erschienen in: Wiener klinische Wochenschrift 1-2/2017

01.01.2017 | original article

Diagnostic accuracy of the 14C-urea breath test in Helicobacter pylori infections: a meta-analysis

verfasst von: Qiaohui Zhou, Ling Li, Yaowei Ai, Zhihong Pan, Mingwen Guo, MD Jingbo Han

Erschienen in: Wiener klinische Wochenschrift | Ausgabe 1-2/2017

Einloggen, um Zugang zu erhalten
share
TEILEN

Summary

Objectives

To summarize and appraise the available literature regarding the use of the 14C-urea breath test in the diagnosis of Helicobacter pylori infections in adult patients with dyspepsia and to calculate pooled diagnostic accuracy measures.

Methods

We systematically searched the PubMed, EMBASE, Cochrane Library, Chinese Journals Full-text (CNKI) and CBMDisc databases to identify published data regarding the sensitivity, specificity, and other measures of diagnostic accuracy of the 14C-urea breath test in the diagnosis of Helicobacter pylori infections in adult patients with dyspeptic symptoms. Risk of bias was assessed using the QUADAS (Quality Assessment of Diagnostic Accuracy Studies)-2 tool. Statistical analyses were performed using Meta-Disc 1.4 software and STATA.

Results

Eighteen studies met the inclusion criteria. Pooled results indicated that the 14C-urea breath test showed a diagnostic sensitivity of 0.96 (95% CI 0.95 to 0.96) and specificity of 0.93 (95% CI 0.91 to 0.94). The positive like ratio (PLR) was 12.27 (95% CI 8.17 to 18.44), the negative like ratio (NLR) was 0.05 (95% CI 0.04 to 0.07), and the area under the curve was 0.985. The DOR was 294.95 (95% CI 178.37 to 487.70). The 14C-urea breath test showed sufficient sensitivity and specificity for diagnosing Helicobacter pylori infection, but unexplained heterogeneity after meta-regression and several subgroup analyses remained.

Conclusions

The UBT has high accuracy for diagnosing H. pylori infections in adult patients with dyspepsia. However, the reliability of these diagnostic meta-analytic estimates is limited by significant heterogeneity due to unknown factors.
Vorheriger Artikel Pretransplantation monitoring of HLA antibodies by complement dependent cytotoxicity and Luminex-based assays
Nächster Artikel Prescription of oral antidiabetic drugs in Tyrol – Data from the Tyrol diabetes registry 2012–2015
Literatur
1.
Marshall BJ, Barrett LJ, Prakash C, McCallum RW, Guerrant RL. Urea protects Helicobacter (Campylobacter) pylori from the bactericidal effect of acid. Gastroenterology. 1990;99(3):697–702. CrossRefPubMed
2.
Lynch DA, Mapstone NP, Clarke AM, Jackson P, Dixon MF, Quirke P, et al. Cell proliferation in the gastric corpus in Helicobacter pylori associated gastritis and after gastric resection. Gut. 1995;36(3):351–3. CrossRefPubMedPubMedCentral
3.
Perri F, Clemente R, Festa V, Annese V, Quitadamo M, Rutgeerts P, et al. Patterns of symptoms in functional dyspepsia: role of Helicobacter pylori infection and delayed gastric emptying. Am J Gastroenterol. 1998;93(11):2082–8. CrossRefPubMed
4.
Leide-Svegborn S, Stenstrom K, Olofsson M, Mattsson S, Nilsson LE, Nosslin B, et al. Biokinetics and radiation doses for carbon-14 urea in adults and children undergoing the Helicobacter pylori breath test. Eur J Nucl Med. 1999;26(6):573–80. CrossRefPubMed
5.
Raju GS, Smith MJ, Morton D, Bardhan KD. Mini-dose (1-microCi) 14C-urea breath test for the detection of Helicobacter pylori. Am J Gastroenterol. 1994;89(7):1027–31. PubMed
6.
Deville WL, Buntinx F, Bouter LM, Montori VM, de Vet HC, van der Windt DA, et al. Conducting systematic reviews of diagnostic studies: didactic guidelines. BMC Med Res Methodol. 2002;2:9. CrossRefPubMedPubMedCentral
7.
Zhang J, Xu ZW, Li K. Evaluation on the effect index of diagnostic test. Chin J Evid-based Med. 2013;126(7):890–5.
8.
Whiting PF, Rutjes AW, Westwood ME, Mallett S, Deeks JJ, Reitsma JB, et al. QUADAS-2: a revised tool for the quality assessment of diagnostic accuracy studies. Ann Intern Med. 2011;155(8):529–36. CrossRefPubMed
9.
Zamora J, Abraira V, Muriel A, Khan K, Coomarasamy A. Meta-DiSc: a software for meta-analysis of test accuracy data. BMC Med Res Methodol. 2006;6:31. CrossRefPubMedPubMedCentral
10.
Chen JP, Xu CP, Chen SJ, Xu QW, Liu FX, Wang ZH, et al. Microdose capsule-based 14C-urea breath test for the diagnosis of Helicobacter pylori infection. J Third Mil Med Univ. 1997;19(2):317–9.
11.
Jiang HM, Wang ZQ, Nan LY, Xu Z. Diagnostic value of 14C-Ure breath test in Helicobacter pylori infection. Chin J Clin Gastroenterol. 2002;14(5):212–3.
12.
Li JZ, Wu J, Luo QY, Zhu LR. 14C-Ure breath test in the diagnose of Helicobacter pylori infection. J Radioimmunol. 2004;17(2):156–7.
13.
Lin Q, Tang AL. Capsule-based 14C-urea breath test for the diagnosis of Helicobacter pylori infection. Xinjiang Med J. 2006;36:96–7.
14.
Liu JZ, Cai TT, Yang WY. Diagnostic value of 14C-urea breath test for Hp associated infection. Inn Mong Med J. 2001;33(3):217–8.
15.
Qi XM, Zhou BL, Cheng SZ. Clinical application of 14C – urea breath test in diagnosing Helicobacter pylori infection. J Clin Exp Med. 2013;12(2):105–6.
16.
Wang XB, Zhuang XF, Guo F. Application of two non-invasive diagnostic methods for Helicobacter pylori. J Xinjiang Med Univ. 2012;35(7):949–52.
17.
Xie XH, Wang SF. 14C-urea breath test in the diagnose of Helicobacter pylori infection. Harbin Med J. 2010;30(5):35.
18.
Xing GD, Wang XJ, Li LH, Liu YJ.14 C- urea breath test for the detection of Helicobacter pylori infection in clinical application.Hebei Med. 2003;9(2):188–9.
19.
Zhang DR, Hu GH, Wu F, Xiao SD, Yuan JM, Zhang ZM. Application of 14C – urea breath test for the diagnosis of Helicobacter pylori infection. Shanghai Med J. 1996;19(7):373–5.
20.
Gurbuz AK, Ozel AM, Narin Y, Yazgan Y, Baloglu H, Demirturk L. Is the remarkable contradiction between histology and 14C urea breath test in the detection of Helicobacter pylori due to false-negative histology or false-positive 14C urea breath test? J Int Med Res. 2005;33(6):632–40. CrossRefPubMed
21.
Ozdemir E, Karabacak NI, Degertekin B, Cirak M, Dursun A, Engin D, et al. Could the simplified (14)C urea breath test be a new standard in noninvasive diagnosis of Helicobacter pylori infection? Ann Nucl Med. 2008;22(7):611–6. CrossRefPubMed
22.
Ozturk E, Yesilova Z, Ilgan S, Arslan N, Erdil A, Celasun B, et al. A new, practical, low-dose 14C-urea breath test for the diagnosis of Helicobacter pylori infection: clinical validation and comparison with the standard method. Eur J Nucl Med Mol Imaging. 2003;30(11):1457–62. CrossRefPubMed
23.
Allardyce RA, Chapman BA, Tie AB, Burt MJ, Yeo KJ, Keenan JI, et al. 37 kBq 14C-urea breath test and gastric biopsy analyses of H. pylori infection. Aust N Z J Surg. 1997;67(1):31–4. CrossRefPubMed
24.
Gomes AT, Coelho LK, Secaf M, Modena JL, Troncon LE, Oliveira RB. Accuracy of the 14C-urea breath test for the diagnosis of Helicobacter pylori. Sao Paulo Med J. 2002;120(3):68–71. CrossRefPubMed
25.
Marshall BJ, Plankey MW, Hoffman SR, Boyd CL, Dye KR, Frierson HF Jr., et al. A 20-minute breath test for helicobacter pylori. Am J Gastroenterol. 1991;86(4):438–45. PubMed
26.
Rasool S, Abid S, Jafri W. Validity and cost comparison of 14carbon urea breath test for diagnosis of H pylori in dyspeptic patients. World J Gastroenterol. 2007;13(6):925–9. CrossRefPubMedPubMedCentral
27.
Surveyor I, Goodwin CS, Mullan BP, Geelhoed E, Warren JR, Murray RN, et al. The 14C-urea breath-test for the detection of gastric Campylobacter pylori infection. Med J Aust. 1989;151(8):435–9. PubMed
28.
Deeks JJ, Macaskill P, Irwig L. The performance of tests of publication bias and other sample size effects in systematic reviews of diagnostic test accuracy was assessed. J Clin Epidemiol. 2005;58(9):882–93. CrossRefPubMed
29.
Pathak CM, Bhasin DK, Pramod KA, Khanduja KL. 14C-urea breath test as a ‘gold standard’ for detection of Helicobacter pylori infection. Med Sci Monit. 2004;10(8):Le14–Le15. PubMed
30.
Gonzalez P, Galleguillos C, Massardo T, Rivera M, Morales A, Smok G, et al. Could the [14C]urea breath test be proposed as a ‘gold standard’ for detection of Helicobacter pylori infection? Med Sci Monit. 2003;9(8):Cr363–Cr368. PubMed
31.
Ferwana M, Abdulmajeed I, Alhajiahmed A, Madani W, Firwana B, Hasan R, et al. Accuracy of urea breath test in Helicobacter pylori infection: meta-analysis. World J Gastroenterol. 2015;21(4):1305–14. CrossRefPubMedPubMedCentral
32.
Bazzoli F, Zagari M, Pozzato P, Fossi S, Ricciardiello GL, Nicolini G, et al. Diagnosis of Helicobacter pylori infection: non-invasive diagnostic tests. Ital J Gastroenterol Hepatol. 1998;30(Suppl 3):S313–S314. PubMed
33.
Korstanje A, van Eeden S, Offerhaus GJ, Sabbe LJ, den Hartog G, Biemond I, et al. The 13carbon urea breath test for the diagnosis of Helicobacter pylori infection in subjects with atrophic gastritis: evaluation in a primary care setting. Aliment Pharmacol Therapeutics. 2006;24(4):643–50. CrossRef
34.
Romagnuolo J, Schiller D, Bailey RJ. Using breath tests wisely in a gastroenterology practice: an evidence-based review of indications and pitfalls in interpretation. Am J Gastroenterol. 2002;97(5):1113–26. CrossRefPubMed
Metadaten
Titel
Diagnostic accuracy of the 14C-urea breath test in Helicobacter pylori infections: a meta-analysis
verfasst von
Qiaohui Zhou
Ling Li
Yaowei Ai
Zhihong Pan
Mingwen Guo
MD Jingbo Han
Publikationsdatum
01.01.2017
Verlag
Springer Vienna
Erschienen in
Wiener klinische Wochenschrift / Ausgabe 1-2/2017
Print ISSN: 0043-5325
Elektronische ISSN: 1613-7671
DOI
https://doi.org/10.1007/s00508-016-1117-3

Weitere Artikel der Ausgabe 1-2/2017

Wiener klinische Wochenschrift 1-2/2017 Zur Ausgabe

MUW

MUW Researcher of the Month Jänner 2017

original article

Glycemia management in a Slovenian general hospital

original article

No common understanding of profession terms utilized in health services research

mitteilungen der gesellschaft der ärzte in wien

Veranstaltungen

original article

Can we still stop the migration of physicians from Austria?

original article

Pretransplantation monitoring of HLA antibodies by complement dependent cytotoxicity and Luminex-based assays

Version: 0.2148.0