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29.06.2018 | review article

Diagnosis of Helicobacter pylori infection

A short review

Zeitschrift:
Wiener klinische Wochenschrift
Autoren:
Ante Tonkic, Jonatan Vukovic, Pavle Vrebalov Cindro, Valdi Pesutic Pisac, Marija Tonkic

Summary

Helicobacter pylori infections represent an important factor in the pathogenesis of chronic gastritis, peptic ulcer, MALT lymphoma and gastric adenocarcinoma. The recently published Maastricht V/Florence consensus report indicated that the urea breath test using 13 C urea still remains the best non-invasive test to diagnose H. pylori infections with high sensitivity and specificity. Among the stool antigen tests, the ELISA monoclonal antibody test is a rational option. Effective therapy should be based only on susceptibility testing in regions with documented high clarithromycin resistance (>15%). Advanced high-resolution endoscopic technologies enable increased diagnostic accuracy for detection of H. pylori infections.

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