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Erschienen in: Wiener klinische Wochenschrift 19-20/2012

01.10.2012 | original article

Determinants of exercise capacity in dilated cardiomyopathy: a prospective, explorative cohort study

verfasst von: Wilhelm Grander, MD, Bernhard Koller, MD, Johannes Schwaiger, MD, Herbert Tilg, MD, Martin W. Dünser, MD

Erschienen in: Wiener klinische Wochenschrift | Ausgabe 19-20/2012

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Summary

Background

Exercise capacity in patients with dilated cardiomyopathy has low correlation to resting left ventricular function. Dysfunctional autonomic activity, cardiomechanics and inflammation are associated with exercise capacity but were investigated under inhomogeneous situations. It remains essentially unclear which factor mainly determines exercise capacity in dilated cardiomyopathy.

Methods

In a prospective, observational study in a narrow time frame we assessed clinically, inflammatory, hemodynamic and, autonomic parameters as well as echocardiographic measures to explore independent determinants of exercise capacity in 28 treated patients with dilated cardiomyopathy.

Results

Right ventricular end-diastolic diameter, tricuspid regurgitation velocity, and sympathovagal balance were independent determinants of exercise capacity (B coefficient, 69; CI 95 %, 15–122; p = 0.004); (B coefficient, − 226; CI 95 %, − 374 to − 79; p = 0.007) and (B coefficient, − 104; CI 95 %, − 172 to − 37), respectively. C-reactive protein, serum creatinin and body mass index were independently associated with right ventricular end-diastolic diameter (B coefficient, 0.34; CI 95 %, 0.12–0.56; p = 0.004); (B coefficient, 0.9; CI 95 %, 0.34–1.455; p = 0.003); and (B coefficient, 0.09; CI 95 %, 0.02–0.15; p = 0.01), respectively.

Conclusions

In stable patients with dilated cardiomyopathy, autonomic modulation, and right ventricular dysfunction may be the most important determinants of exercise capacity, whereas inflammation, kidney dysfunction, and body mass index are independently associated with right ventricle remodeling.
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Metadaten
Titel
Determinants of exercise capacity in dilated cardiomyopathy: a prospective, explorative cohort study
verfasst von
Wilhelm Grander, MD
Bernhard Koller, MD
Johannes Schwaiger, MD
Herbert Tilg, MD
Martin W. Dünser, MD
Publikationsdatum
01.10.2012
Verlag
Springer Vienna
Erschienen in
Wiener klinische Wochenschrift / Ausgabe 19-20/2012
Print ISSN: 0043-5325
Elektronische ISSN: 1613-7671
DOI
https://doi.org/10.1007/s00508-012-0228-8

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