Skip to main content
main-content

Tipp

Weitere Artikel dieser Ausgabe durch Wischen aufrufen

01.10.2012 | original article | Ausgabe 19-20/2012

Wiener klinische Wochenschrift 19-20/2012

Determinants of exercise capacity in dilated cardiomyopathy: a prospective, explorative cohort study

Zeitschrift:
Wiener klinische Wochenschrift > Ausgabe 19-20/2012
Autoren:
MD Wilhelm Grander, MD Bernhard Koller, MD Johannes Schwaiger, MD Herbert Tilg, MD Martin W. Dünser

Summary

Background

Exercise capacity in patients with dilated cardiomyopathy has low correlation to resting left ventricular function. Dysfunctional autonomic activity, cardiomechanics and inflammation are associated with exercise capacity but were investigated under inhomogeneous situations. It remains essentially unclear which factor mainly determines exercise capacity in dilated cardiomyopathy.

Methods

In a prospective, observational study in a narrow time frame we assessed clinically, inflammatory, hemodynamic and, autonomic parameters as well as echocardiographic measures to explore independent determinants of exercise capacity in 28 treated patients with dilated cardiomyopathy.

Results

Right ventricular end-diastolic diameter, tricuspid regurgitation velocity, and sympathovagal balance were independent determinants of exercise capacity (B coefficient, 69; CI 95 %, 15–122; p = 0.004); (B coefficient, − 226; CI 95 %, − 374 to − 79; p = 0.007) and (B coefficient, − 104; CI 95 %, − 172 to − 37), respectively. C-reactive protein, serum creatinin and body mass index were independently associated with right ventricular end-diastolic diameter (B coefficient, 0.34; CI 95 %, 0.12–0.56; p = 0.004); (B coefficient, 0.9; CI 95 %, 0.34–1.455; p = 0.003); and (B coefficient, 0.09; CI 95 %, 0.02–0.15; p = 0.01), respectively.

Conclusions

In stable patients with dilated cardiomyopathy, autonomic modulation, and right ventricular dysfunction may be the most important determinants of exercise capacity, whereas inflammation, kidney dysfunction, and body mass index are independently associated with right ventricle remodeling.

Bitte loggen Sie sich ein, um Zugang zu diesem Inhalt zu erhalten

Literatur
Über diesen Artikel

Weitere Artikel der Ausgabe 19-20/2012

Wiener klinische Wochenschrift 19-20/2012 Zur Ausgabe

MUW resarcher of the month

Researcher of the month, Oktober 2012

mitteilungen der gesellschaft der ärzte in wien

Veranstaltungen