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Erschienen in: memo - Magazine of European Medical Oncology 4/2022

13.10.2022 | short review

Current standards in the surgical treatment of pancreatic and small intestinal neuroendocrine tumors

verfasst von: PD Ulla Klaiber, M.D., PD Stefan Stättner, M.D.

Erschienen in: memo - Magazine of European Medical Oncology | Ausgabe 4/2022

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Summary

Pancreatic and small intestinal neuroendocrine tumors comprise relatively rare and distinctly heterogenous tumor entities which need to be managed quite differently depending on their location, the local and distant tumor extent, hormonal activity, size, and proliferative activity. The best treatment strategy for each subgroup is controversial since evidence from prospective randomized controlled trials is lacking and treatment guidelines are mainly based on results from retrospective studies. Patients with resectable pancreatic neuroendocrine tumors (pNETs) are generally potential candidates for surgical resection, especially in case of functional pNETs. However, in patients with small asymptomatic pNETs not exceeding 2 cm in size current guidelines recommend active surveillance as an alternative to primary resection. Timing of surgery (primary resection versus watchful waiting) as well as the most beneficial surgical approach (open versus minimally invasive procedures, parenchyma-sparing versus formal resections) need to be further investigated in future clinical trials considering the different patient subgroups with regard to tumor biology and prognosis. Due to the heterogeneity of enteropancreatic NETs and the challenges of pancreatic surgery, affected patients should be treated by an interdisciplinary team of surgical and oncological experts in specialized centers. This review article summarizes the current literature on the surgical and oncological treatment of pNETs and small intestinal NETs (siNETs) with a special focus on sporadic and well-differentiated tumors.
Literatur
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Zurück zum Zitat Niederle B, Selberherr A, Bartsch DK, et al. Multiple endocrine neoplasia type 1 and the pancreas: diagnosis and treatment of functioning and non-functioning pancreatic and duodenal neuroendocrine neoplasia within the MEN1 syndrome—an international consensus statement. Neuroendocrinology. 2021; https://doi.org/10.1159/000511791.CrossRef Niederle B, Selberherr A, Bartsch DK, et al. Multiple endocrine neoplasia type 1 and the pancreas: diagnosis and treatment of functioning and non-functioning pancreatic and duodenal neuroendocrine neoplasia within the MEN1 syndrome—an international consensus statement. Neuroendocrinology. 2021; https://​doi.​org/​10.​1159/​000511791.CrossRef
Metadaten
Titel
Current standards in the surgical treatment of pancreatic and small intestinal neuroendocrine tumors
verfasst von
PD Ulla Klaiber, M.D.
PD Stefan Stättner, M.D.
Publikationsdatum
13.10.2022
Verlag
Springer Vienna
Erschienen in
memo - Magazine of European Medical Oncology / Ausgabe 4/2022
Print ISSN: 1865-5041
Elektronische ISSN: 1865-5076
DOI
https://doi.org/10.1007/s12254-022-00840-7

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