Skip to main content
Erschienen in: Urologie in der Praxis 2/2023

Open Access 07.06.2023 | Urologie | Originalien

COVID-19 (SARS-CoV-2-Infektion): Einfluss auf die männliche Fertilität

verfasst von: PD Dr. med. Alexander Müller

Erschienen in: Urologie in der Praxis | Ausgabe 2/2023

Einloggen, um Zugang zu erhalten

Zusammenfassung

Höhere Sterblichkeit und ein schwererer Krankheitsverlauf sind bei Männern mit SARS-CoV-2-Infektion gegenüber Frauen zu beobachten. Die Hodenfunktion (Samenqualität und Testosteronhaushalt) sowie die Erektionsfunktion sind, zumindest kurzfristig, durch eine COVID-19 Infektion negativ gestört – wobei mögliche Langzeiteffekte noch nicht hinreichend geklärt sind. Bei einer angestrebten Fertilität, inklusive assistierter reproduktionsendokrinologischer Massnahmen oder Kryopräservation benötigen Männer u. a. aufgrund potenziell infektbedingter DNA-Schäden im Erbgut eine kompetente Beratung und einen engen Follow-up.
Literatur
1.
Zurück zum Zitat Moeling K (2021) Within-host and between-host evolution in SARS-CoV-2-new variant’s source. Viruses 13(5):751CrossRef Moeling K (2021) Within-host and between-host evolution in SARS-CoV-2-new variant’s source. Viruses 13(5):751CrossRef
2.
Zurück zum Zitat Li Xuhua QG, Peng W et al (2020) Early transmission dynamics in Wuhan, China, of novel coronavirus-infected pneumonia. N Engl J Med 382(13):1199–1207CrossRef Li Xuhua QG, Peng W et al (2020) Early transmission dynamics in Wuhan, China, of novel coronavirus-infected pneumonia. N Engl J Med 382(13):1199–1207CrossRef
3.
Zurück zum Zitat Pradhan A, Olsson P‑E (2020) Sex differences in severity and mortaliy form COVID-19: are males more vulnerable ? Biol Sex Differ 11(1):53CrossRefPubMedPubMedCentral Pradhan A, Olsson P‑E (2020) Sex differences in severity and mortaliy form COVID-19: are males more vulnerable ? Biol Sex Differ 11(1):53CrossRefPubMedPubMedCentral
4.
Zurück zum Zitat Nassau DE, Best JC, Kresch E, Gonzalez DC, Khodamoradi K, Ramasamy R (2022) Impact of the SARS-CoV‑2 virus on male repdoductive health. BJU Int 129(2):143–150CrossRefPubMed Nassau DE, Best JC, Kresch E, Gonzalez DC, Khodamoradi K, Ramasamy R (2022) Impact of the SARS-CoV‑2 virus on male repdoductive health. BJU Int 129(2):143–150CrossRefPubMed
5.
Zurück zum Zitat Aitken RJ (2021) COVID-19 and human spermatozoa-Potential risks for infertility and sexual transmission? Andrology 9(1):48–52 Aitken RJ (2021) COVID-19 and human spermatozoa-Potential risks for infertility and sexual transmission? Andrology 9(1):48–52
6.
Zurück zum Zitat Li H, Liu L, Zhang D, Xu J, Dai H, Tang N, Su X, Cao B (2020) SARS-CoV‑2 and viral sepsis : observations and hypotheses. Lancet 395(10235):1517–1520CrossRefPubMedPubMedCentral Li H, Liu L, Zhang D, Xu J, Dai H, Tang N, Su X, Cao B (2020) SARS-CoV‑2 and viral sepsis : observations and hypotheses. Lancet 395(10235):1517–1520CrossRefPubMedPubMedCentral
7.
Zurück zum Zitat Villiamson EJ, Walker AJ, Bhaskaran K et al (2020) Factors associated with COVID-19-related death using OpenSAFELY. Nature 584(7821):430–436CrossRef Villiamson EJ, Walker AJ, Bhaskaran K et al (2020) Factors associated with COVID-19-related death using OpenSAFELY. Nature 584(7821):430–436CrossRef
8.
Zurück zum Zitat Yang J, Wang W, Chen Z et al (2020) A Vaccine targeting the RBD of the Sprotein of SARS-CoV‑2 induces protecitve immunity. Nature 586(7830):572–577CrossRefPubMed Yang J, Wang W, Chen Z et al (2020) A Vaccine targeting the RBD of the Sprotein of SARS-CoV‑2 induces protecitve immunity. Nature 586(7830):572–577CrossRefPubMed
9.
Zurück zum Zitat Hoffmann M, Kleine-Weber H, Schroeder S et al (2020) SARS-CoV‑2 Cell Entry Depends on ACE2 and TMPRSS2 and is blocked by a clinically proven protease Inhibitor. Cell 181(2):271–280CrossRefPubMedPubMedCentral Hoffmann M, Kleine-Weber H, Schroeder S et al (2020) SARS-CoV‑2 Cell Entry Depends on ACE2 and TMPRSS2 and is blocked by a clinically proven protease Inhibitor. Cell 181(2):271–280CrossRefPubMedPubMedCentral
10.
Zurück zum Zitat Buonacquisto A, Conflitti AC, Pallotti F et al (2022) COVID-19 Severity and Androgen Receptor Polymorphism. Biol (basel) 11(7):974 Buonacquisto A, Conflitti AC, Pallotti F et al (2022) COVID-19 Severity and Androgen Receptor Polymorphism. Biol (basel) 11(7):974
11.
Zurück zum Zitat Ediz C, Tavukcu HH, Akan S, Kizilkan YE, Alcin A, Oz K, Yilmaz O (2021) Is there any association of COVID-19 with testicular pain and epididymo-orchitis ? Int J Clin Pract 75(3):e13753ffCrossRef Ediz C, Tavukcu HH, Akan S, Kizilkan YE, Alcin A, Oz K, Yilmaz O (2021) Is there any association of COVID-19 with testicular pain and epididymo-orchitis ? Int J Clin Pract 75(3):e13753ffCrossRef
12.
Zurück zum Zitat Abdelhamid MHM, Fellah AA (2023) Elmarghani A Msellati IAA. An Assessment of Men Semen Alterations in SARS-CoV-2: Is Fever the Principa Concern ? Reprod Sci 30(1):72–80CrossRefPubMed Abdelhamid MHM, Fellah AA (2023) Elmarghani A Msellati IAA. An Assessment of Men Semen Alterations in SARS-CoV-2: Is Fever the Principa Concern ? Reprod Sci 30(1):72–80CrossRefPubMed
13.
Zurück zum Zitat Koc E, Keseroglu BB (2021) Does COVID-19 Worsen the semen parameters ? Early results of a Tertiary Healthcare Center. Urol Int 105(9–10):743–748CrossRefPubMed Koc E, Keseroglu BB (2021) Does COVID-19 Worsen the semen parameters ? Early results of a Tertiary Healthcare Center. Urol Int 105(9–10):743–748CrossRefPubMed
14.
Zurück zum Zitat Gacci M, Coppi M, Baldi E et al (2021) Semen impairment and occurrence of SARS-CoV‑2 virus in semen after recovery form COVID-19. Hum Reprod 36(6):1520–1529CrossRefPubMed Gacci M, Coppi M, Baldi E et al (2021) Semen impairment and occurrence of SARS-CoV‑2 virus in semen after recovery form COVID-19. Hum Reprod 36(6):1520–1529CrossRefPubMed
15.
Zurück zum Zitat Coroan G, Vena W, Pizzocaro A et al (2022) Andrological effects of SARS-Cov‑2 infection : a systematic review and meta-analysis. J Endrocrinol Invest 45(12):2207–2219CrossRef Coroan G, Vena W, Pizzocaro A et al (2022) Andrological effects of SARS-Cov‑2 infection : a systematic review and meta-analysis. J Endrocrinol Invest 45(12):2207–2219CrossRef
16.
Zurück zum Zitat Xie Y, Mirzaei M, Kahrizi MS, Shabestrari AM, Riahi SM, Farsimadan M, Roviello G (2022) SARS-CoV‑2 effects on sperm parameters : a meta-analysis study. J Assist Reprod Genet 39(7):155–1563CrossRef Xie Y, Mirzaei M, Kahrizi MS, Shabestrari AM, Riahi SM, Farsimadan M, Roviello G (2022) SARS-CoV‑2 effects on sperm parameters : a meta-analysis study. J Assist Reprod Genet 39(7):155–1563CrossRef
17.
Zurück zum Zitat Paoli D, Pallotti F, Anzuini A et al (2022) Male reproductive health after 3 month from SARS-CoV‑2 infection : a multicentric study. J Endrocrinol Invest 46(1):89–1001 Paoli D, Pallotti F, Anzuini A et al (2022) Male reproductive health after 3 month from SARS-CoV‑2 infection : a multicentric study. J Endrocrinol Invest 46(1):89–1001
18.
Zurück zum Zitat Hajizadeh Maleki B, Tartibian B (2021) COVID-19 and male reproductive function : a prospective, longitudianl cohort study. Reproduction 161(3):319–331CrossRefPubMed Hajizadeh Maleki B, Tartibian B (2021) COVID-19 and male reproductive function : a prospective, longitudianl cohort study. Reproduction 161(3):319–331CrossRefPubMed
19.
Zurück zum Zitat Aitken RJ, Bakos HW (2021) Shoulrd we be measuring DNA damage in human spermatozoa? New light on an old question. Hum Reprod 36(5):1175–1185CrossRefPubMed Aitken RJ, Bakos HW (2021) Shoulrd we be measuring DNA damage in human spermatozoa? New light on an old question. Hum Reprod 36(5):1175–1185CrossRefPubMed
20.
Zurück zum Zitat Deuel JW, Lauria E, Lovey T, Zweifel S, Meier MI, Züst R, Gültekin N, Stettbacher A, Schlagenhauf P (2022) Persistence, prevalence, and polymorphism of sequelae after COVID-19 in unavaccinated, young adults oft he Swiss Armed Forces: a longitudinal, cohort study (LoCoMo). Lancet Infect Dis 22(12):1694–1702CrossRefPubMedPubMedCentral Deuel JW, Lauria E, Lovey T, Zweifel S, Meier MI, Züst R, Gültekin N, Stettbacher A, Schlagenhauf P (2022) Persistence, prevalence, and polymorphism of sequelae after COVID-19 in unavaccinated, young adults oft he Swiss Armed Forces: a longitudinal, cohort study (LoCoMo). Lancet Infect Dis 22(12):1694–1702CrossRefPubMedPubMedCentral
21.
Zurück zum Zitat Zhao H, Sounders C, Carmel M, Anger JT (2021) Low Rates of Urologic Side Effects following Coronavirus disease vaccination : an analysis of the food and drug adminstration vaccine adverse event reporting system. Urology 153:11–13CrossRefPubMed Zhao H, Sounders C, Carmel M, Anger JT (2021) Low Rates of Urologic Side Effects following Coronavirus disease vaccination : an analysis of the food and drug adminstration vaccine adverse event reporting system. Urology 153:11–13CrossRefPubMed
22.
Zurück zum Zitat Safrai M, Herzberg S, Imbar T, Reubinoff B, Dior U, Ben-Meir A (2022) The BNT162b2 mRNA Covid-19 vaccine does not impair sperm parameters. Reprod Biomed Online 44(4):685–688CrossRefPubMedPubMedCentral Safrai M, Herzberg S, Imbar T, Reubinoff B, Dior U, Ben-Meir A (2022) The BNT162b2 mRNA Covid-19 vaccine does not impair sperm parameters. Reprod Biomed Online 44(4):685–688CrossRefPubMedPubMedCentral
23.
Zurück zum Zitat Gonzalez DC, Nassau DE, Khodamoradi K, Ibrahim E, Blachman-Braun R, Ory J, Ramasamy R (2021) Sperm Parameters before and after COVID-19 mRNA vaccination. JAMA 326(3):273–274CrossRefPubMedPubMedCentral Gonzalez DC, Nassau DE, Khodamoradi K, Ibrahim E, Blachman-Braun R, Ory J, Ramasamy R (2021) Sperm Parameters before and after COVID-19 mRNA vaccination. JAMA 326(3):273–274CrossRefPubMedPubMedCentral
25.
Zurück zum Zitat Kadihasanoglu M, Aktas S, Yardimci E, Aral H, Kadioglu A (2021) SARS-CoV‑2 Peneumonia affets male reproductive hormone levels : a prospective , cohort study. J Sex Med 18(2):256–264CrossRefPubMed Kadihasanoglu M, Aktas S, Yardimci E, Aral H, Kadioglu A (2021) SARS-CoV‑2 Peneumonia affets male reproductive hormone levels : a prospective , cohort study. J Sex Med 18(2):256–264CrossRefPubMed
26.
Zurück zum Zitat Salonia A, Pontillo M, Capogrossa P et al (2021) Severely low testosterone in males with COVID-19: A case-control study. Andrology 9(4):1043–1052CrossRefPubMedPubMedCentral Salonia A, Pontillo M, Capogrossa P et al (2021) Severely low testosterone in males with COVID-19: A case-control study. Andrology 9(4):1043–1052CrossRefPubMedPubMedCentral
27.
Zurück zum Zitat Salonia A, Pontillo M, Capogrossa P et al (2022) Testosterone in males with COVID-19: A 7‑month cohort study. Andrology 10(1):34–41CrossRefPubMed Salonia A, Pontillo M, Capogrossa P et al (2022) Testosterone in males with COVID-19: A 7‑month cohort study. Andrology 10(1):34–41CrossRefPubMed
28.
Zurück zum Zitat Rambhatla A, Bronkema CJ, Corsi N et al (2021) COVID-19 infection in men on testosterone replacement therapy. J Sex Med 18(1):215–218CrossRefPubMed Rambhatla A, Bronkema CJ, Corsi N et al (2021) COVID-19 infection in men on testosterone replacement therapy. J Sex Med 18(1):215–218CrossRefPubMed
29.
Zurück zum Zitat Sansone A, Mollaioli D, Giocca G, Limoncin E, Colonnello E, Vena W, Jannini EA (2021) Addressing male sexual and reproductive health in the wake of COVID-19. Outbreak J Endrocrinol Invest 44(2):223–231CrossRef Sansone A, Mollaioli D, Giocca G, Limoncin E, Colonnello E, Vena W, Jannini EA (2021) Addressing male sexual and reproductive health in the wake of COVID-19. Outbreak J Endrocrinol Invest 44(2):223–231CrossRef
30.
Zurück zum Zitat Sansone A, Mollaioli D, Ciocca G, Colonnello E, Limoncin E, Balercia G, Jannini EA (2021) “Mask up to keep it up”: Preliminary evidence of the association between erectile dysfunction and COVID-19. Andrology 9(4):1053–1059CrossRefPubMedPubMedCentral Sansone A, Mollaioli D, Ciocca G, Colonnello E, Limoncin E, Balercia G, Jannini EA (2021) “Mask up to keep it up”: Preliminary evidence of the association between erectile dysfunction and COVID-19. Andrology 9(4):1053–1059CrossRefPubMedPubMedCentral
Metadaten
Titel
COVID-19 (SARS-CoV-2-Infektion): Einfluss auf die männliche Fertilität
verfasst von
PD Dr. med. Alexander Müller
Publikationsdatum
07.06.2023
Verlag
Springer Vienna
Erschienen in
Urologie in der Praxis / Ausgabe 2/2023
Print ISSN: 2661-8737
Elektronische ISSN: 2661-8745
DOI
https://doi.org/10.1007/s41973-023-00217-1

Weitere Artikel der Ausgabe 2/2023

Urologie in der Praxis 2/2023 Zur Ausgabe

Editorial

Editorial

Die Urologische Blickdiagnose

Blickdiagnose Urologie