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Gynäkologie in der Praxis

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01.07.2021 | Originalien

Corpus luteum, vaskuläre Gesundheit und Präeklampsierisiko nach ART

verfasst von: Christian Trautmann, Prof. Dr. med. Frauke von Versen-Höynck, M.Sc.

Erschienen in: Gynäkologie in der Praxis | Ausgabe 3/2021

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Zusammenfassung

Die maternale perikonzeptionelle Gesundheit als auch die Gesundheit in der Frühschwangerschaft bestimmen das Risiko für die Entwicklung einer Präeklampsie mit. Hierbei kommt insbesondere im Rahmen der assistierten Reproduktion dem Corpus luteum und dessen vasoaktiven Sekretionsprodukten, wie dem Relaxin, eine Bedeutung zu. Dieser Artikel beschreibt mögliche Zusammenhänge zwischen der Corpus-luteum-Anzahl, der maternalen Gefäßgesundheit und dem Präeklampsierisiko. Dabei wird insbesondere auf das Fehlen des Corpus luteum bei artifiziellen Auftauzyklen eingegangen, die neben einer gestörten maternalen kardiovaskulären Adaptation in der Frühschwangerschaft mit einem erhöhten Präeklampsierisiko einhergehen können.

Vorheriger Artikel Physische, psychische und soziale Entwicklung der nach intrazytoplasmatischer Spermieninjektion geborenen Kinder – die Deutsche ICSI-Langzeitstudie

Nächster Artikel Hyperprolaktinämie bei der Frau

Burton GJ, Redman CW, Roberts JM et al (2019) Pre-eclampsia: pathophysiology and clinical implications. BMJ 366:l2381PubMedCrossRef

Abalos E, Cuesta C, Grosso AL et al (2013) Global and regional estimates of preeclampsia and eclampsia: a systematic review. Eur J Obstet Gynecol Reprod Biol 170(1):1–7PubMedCrossRef

Ebisch IM, Thomas CM, Wetzels AM et al (2008) Review of the role of the plasminogen activator system and vascular endothelial growth factor in subfertility. Fertil Steril 90(6):2340–2350PubMedCrossRef

Kampfer C, Saller S, Windschuttl S et al (2014) Pigment-Epithelium Derived Factor (PEDF) and the human ovary: a role in the generation of ROS in granulosa cells. Life Sci 97(2):129–136PubMedCrossRef

Conrad KP (2011) Emerging role of relaxin in the maternal adaptations to normal pregnancy: implications for preeclampsia. Semin Nephrol 31(1):15–32PubMedPubMedCentralCrossRef

Emmi AM, Skurnick J, Goldsmith LT et al (1991) Ovarian control of pituitary hormone secretion in early human pregnancy. J Clin Endocrinol Metab 72(6):1359–1369PubMedCrossRef

Devoto L, Fuentes A, Kohen P et al (2009) The human corpus luteum: life cycle and function in natural cycles. Fertil Steril 92(3):1067–1079PubMedCrossRef

Levitz M, Young BK (1977) Estrogens in pregnancy. Vitam Horm 35:109–147PubMedCrossRef

Schock H, Zeleniuch-Jacquotte A, Lundin E et al (2016) Hormone concentrations throughout uncomplicated pregnancies: a longitudinal study. BMC Pregnancy Childbirth 16(1):146PubMedPubMedCentralCrossRef

10.

Byers MJ, Zangl A, Phernetton TM et al (2005) Endothelial vasodilator production by ovine uterine and systemic arteries: ovarian steroid and pregnancy control of ERalpha and ERbeta levels. J Physiol 565(Pt 1):85–99PubMedPubMedCentralCrossRef

11.

Young SL, Savaris RF, Lessey BA et al (2017) Effect of randomized serum progesterone concentration on secretory endometrial histologic development and gene expression. Hum Reprod 32(9):1903–1914PubMedPubMedCentralCrossRef

12.

Simoncini T, Fu XD, Caruso A et al (2007) Drospirenone increases endothelial nitric oxide synthesis via a combined action on progesterone and mineralocorticoid receptors. Hum Reprod 22(8):2325–2334PubMedCrossRef

13.

Hermenegildo C, Oviedo PJ, García-Martínez MC et al (2005) Progestogens stimulate prostacyclin production by human endothelial cells. Hum Reprod 20(6):1554–1561PubMedCrossRef

14.

Conrad KP (2020) Evidence for corpus luteal and endometrial origins of adverse pregnancy outcomes in women conceiving with or without assisted reproduction. Obstet Gynecol Clin North Am 47(1):163–181PubMedPubMedCentralCrossRef

15.

Staff AC, Fjeldstad HE, Fosheim IK et al (2020) Failure of physiological transformation and spiral artery atherosis: their roles in preeclampsia. Am J Obstet Gynecol. https://doi.org/10.1016/j.ajog.2020.09.026CrossRefPubMed

16.

Franz M, Kainer F, Husslein P (2015) Physiologie des mütterlichen Organismus und Erkrankungen in der Schwangerschaft. Die Geburtshilfe. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-44369-9_21-1CrossRef

17.

Sherwood OD (2004) Relaxin’s physiological roles and other diverse actions. Endocr Rev 25(2):205–234PubMedCrossRef

18.

Wiegel RE, Danser AHJ, Steegers-Theunissen RP et al (2020) Determinants of maternal renin-angiotensin-aldosterone-system activation in early pregancy: insights from 2 cohorts. J Clin Endocrinol Metab 105(11):1–13CrossRef

19.

Itskovitz J, Sealey JE (1987) Ovarian prorenin-renin-angiotensin system. Obstet Gynecol Surv 42(9):545–551PubMedCrossRef

20.

Speth RC, Daubert DL, Grove KL (1999) Angiotensin II: a reproductive hormone too? Regul Pept 79(1):25–40PubMedCrossRef

21.

Yoshimura Y (1997) The ovarian renin-angiotensin system in reproductive physiology. Front Neuroendocrinol 18(3):247–291PubMedCrossRef

22.

Conrad KP, Baker VL (2013) Corpus luteal contribution to maternal pregnancy physiology and outcomes in assisted reproductive technologies. Am J Physiol Regul Integr Comp Physiol 304(2):R69–R72PubMedCrossRef

23.

Conrad KP, Graham GM, Chi YY et al (2019) Potential influence of the corpus luteum on circulating reproductive and volume regulatory hormones, angiogenic and immunoregulatory factors in pregnant women. Am J Physiol Endocrinol Metab 317(4):E677–E685PubMedPubMedCentralCrossRef

24.

von Versen-Höynck F, Hackl S, Selamet Tierney ES et al (2020) Maternal vascular health in pregnancy and postpartum after assisted reproduction. Hypertension 75(2):549–560CrossRef

25.

Khaw A, Kametas NA, Turan OM et al (2008) Maternal cardiac function and uterine artery Doppler at 11–14 weeks in the prediction of pre-eclampsia in nulliparous women. BJOG 115(3):369–376PubMedCrossRef

26.

De Paco C, Kametas N, Rencoret G et al (2008) Maternal cardiac output between 11 and 13 weeks of gestation in the prediction of preeclampsia and small for gestational age. Obstet Gynecol 111(2 Pt 1):292–300PubMedCrossRef

27.

Salas SP, Marshall G, Gutierrez BL et al (2006) Time course of maternal plasma volume and hormonal changes in women with preeclampsia or fetal growth restriction. Hypertension 47(2):203–208PubMedCrossRef

28.

Novak J, Danielson LA, Kerchner LJ et al (2001) Relaxin is essential for renal vasodilation during pregnancy in conscious rats. J Clin Invest 107(11):1469–1475PubMedPubMedCentralCrossRef

29.

Debrah DO, Novak J, Matthews JE et al (2006) Relaxin is essential for systemic vasodilation and increased global arterial compliance during early pregnancy in conscious rats. Endocrinology 147(11):5126–5131PubMedCrossRef

30.

Danielson LA, Sherwood OD, Conrad KP (1999) Relaxin is a potent renal vasodilator in conscious rats. J Clin Invest 103(4):525–533PubMedPubMedCentralCrossRef

31.

Chapman AB, Zamudio S, Woodmansee W et al (1997) Systemic and renal hemodynamic changes in the luteal phase of the menstrual cycle mimic early pregnancy. Am J Physiol 273(5 Pt 2):F777–F782PubMed

32.

Petersen JW, Liu J, Chi YY et al (2017) Comparison of multiple non-invasive methods of measuring cardiac output during pregnancy reveals marked heterogeneity in the magnitude of cardiac output change between women. Physiol Rep 5(8):e13223PubMedPubMedCentralCrossRef

33.

Jackson RA, Gibson KA, Wu YW et al (2004) Perinatal outcomes in singletons following in vitro fertilization: a meta-analysis. Obstet Gynecol 103(3):551–563PubMedCrossRef

34.

Helmerhorst FM, Perquin DA, Donker D et al (2004) Perinatal outcome of singletons and twins after assisted conception: a systematic review of controlled studies. BMJ 328(7434):261PubMedPubMedCentralCrossRef

35.

Maman E, Lunenfeld E, Levy A et al (1998) Obstetric outcome of singleton pregnancies conceived by in vitro fertilization and ovulation induction compared with those conceived spontaneously. Fertil Steril 70(2):240–245PubMedCrossRef

36.

Pinborg A, Wennerholm UB, Romundstad LB et al (2013) Why do singletons conceived after assisted reproduction technology have adverse perinatal outcome? Systematic review and meta-analysis. Hum Reprod Update 19(2):87–104PubMedCrossRef

37.

Salha O, Sharma V, Dada T et al (1999) The influence of donated gametes on the incidence of hypertensive disorders of pregnancy. Hum Reprod 14(9):2268–2273PubMedCrossRef

38.

Sites CK, Wilson D, Barsky M et al (2017) Embryo cryopreservation and preeclampsia risk. Fertil Steril 108(5):784–790PubMedCrossRef

39.

Barsky M, Marie StP, Rahil T et al (2016) Are perinatal outcomes affected by blastocyst vitrification and warming? Am J Obstet Gynecol 215(5):603e1–603e5CrossRef

40.

Chen ZJ, Shi Y, Sun Y et al (2016) Fresh versus frozen embryos for infertility in the polycystic ovary syndrome. N Engl J Med 375(6):523–533PubMedCrossRef

41.

Sazonova A, Kallen K, Thurin-Kjellberg A et al (2012) Obstetric outcome in singletons after in vitro fertilization with cryopreserved/thawed embryos. Hum Reprod 27(5):1343–1350PubMedCrossRef

42.

Wei D, Liu JY, Sun Y et al (2019) Frozen versus fresh single blastocyst transfer in ovulatory women: a multicentre, randomised controlled trial. Lancet 393(10178):1310–1318PubMedCrossRef

43.

Roque M, Haahr T, Geber S et al (2019) Fresh versus elective frozen embryo transfer in IVF/ICSI cycles: a systematic review and meta-analysis of reproductive outcomes. Hum Reprod Update 25(1):2–14PubMedCrossRef

44.

Saito K, Kuwahara A, Ishikawa T et al (2019) Endometrial preparation methods for frozen-thawed embryo transfer are associated with altered risks of hypertensive disorders of pregnancy, placenta accreta, and gestational diabetes mellitus. Hum Reprod 34(8):1567–1575PubMedCrossRef

45.

Ishihara O, Araki R, Kuwahara A et al (2014) Impact of frozen-thawed single-blastocyst transfer on maternal and neonatal outcome: an analysis of 277,042 single-embryo transfer cycles from 2008 to 2010 in Japan. Fertil Steril 101(1):128–133PubMedCrossRef

46.

Ginstrom Ernstad E, Wennerholm UB, Khatibi A et al (2019) Neonatal and maternal outcome after frozen embryo transfer: Increased risks in programmed cycles. Am J Obstet Gynecol 221(2):126e1–126e18CrossRef

47.

Lin J, Zhao J, Hao G et al (2020) Maternal and neonatal complications after natural vs. Hormone replacement therapy cycle regimen for frozen single Blastocyst transfer. Front Med 7:338CrossRef

48.

Opdahl S, Henningsen AA, Tiitinen A et al (2015) Risk of hypertensive disorders in pregnancies following assisted reproductive technology: a cohort study from the CoNARTaS group. Hum Reprod 30(7):1724–1731PubMedCrossRef

49.

Maheshwari A, Pandey S, Amalraj Raja E et al (2018) Is frozen embryo transfer better for mothers and babies? Can cumulative meta-analysis provide a definitive answer? Hum Reprod Update 24(1):35–58PubMedCrossRef

50.

Sha T, Yin X, Cheng W et al (2018) Pregnancy-related complications and perinatal outcomes resulting from transfer of cryopreserved versus fresh embryos in vitro fertilization: a meta-analysis. Fertil Steril 109(2):330–342.e9PubMedCrossRef

51.

Yang M, Lin L, Sha C et al (2020) Which is better for mothers and babies: fresh or frozen-thawed blastocyst transfer? BMC Pregnancy Childbirth 20(1):559PubMedPubMedCentralCrossRef

52.

Wang B, Zhang J, Zhu Q et al (2020) Effects of different cycle regimens for frozen embryo transfer on perinatal outcomes of singletons. Hum Reprod 35(7):1612–1622PubMedCrossRef

53.

Zong L, Liu P, Zhou L et al (2020) Increased risk of maternal and neonatal complications in hormone replacement therapy cycles in frozen embryo transfer. Reprod Biol Endocrinol 18(1):36PubMedPubMedCentralCrossRef

54.

Asserhøj LL, Spangmose AL, Aaris Henningsen AK et al (2021) Adverse obstetric and perinatal outcomes in 1,136 singleton pregnancies conceived after programmed frozen embryo transfer (FET) compared with natural cycle FET. Fertil Steril 115(4):947–956PubMedCrossRef

55.

Makhijani R, Bartels C, Godiwala P et al (2020) Maternal and perinatal outcomes in programmed versus natural vitrified-warmed blastocyst transfer cycles. Reprod Biomed Online 41(2):300–308PubMedCrossRef

56.

Zhang J, Wei M, Bian X et al (2021) Letrozole-induced frozen embryo transfer cycles are associated with a lower risk of hypertensive disorders of pregnancy among women with polycystic ovary syndrome. Am J Obstet Gynecol. https://doi.org/10.1016/j.ajog.2021.01.024CrossRefPubMed

57.

Hu KL, Zhang D, Li R (2021) Endometrium preparation and perinatal outcomes in women undergoing single-blastocyst transfer in frozen cycles. Fertil Steril. https://doi.org/10.1016/j.fertnstert.2020.12.016CrossRefPubMed

58.

Zaat TR, Brink AJ, de Bruin JP et al (2021) Increased obstetric and neonatal risks in artificial cycles for frozen embryo transfers? Reprod Biomed Online 42(5):919–929PubMedCrossRef

59.

von Versen-Höynck F, Schaub AM, Chi YY et al (2019) Increased preeclampsia risk and reduced aortic compliance with in vitro fertilization cycles in the absence of a corpus luteum. Hypertension 73(3):640–649CrossRef

60.

Wang Z, Liu H, Song H et al (2020) Increased risk of pre-eclampsia after frozen-thawed embryo transfer in programming cycles. Front Med 7:104CrossRef

61.

Roelens C, Racca A, Mackens S et al (2020) Artificially prepared frozen embryo transfer cycles are associated with an increased risk of preeclampsia. Hum Reprod 35:108–109 (In: 36th Annual Meeting of ESHRE)

62.

Conrad KP, Petersen JW, Chi YY et al (2019) Maternal cardiovascular dysregulation during early pregnancy after in vitro fertilization cycles in the absence of a corpus luteum. Hypertension 74(3):705–715PubMedCrossRef

63.

von Versen-Höynck F, Narasimhan P, Selamet Tierney ES et al (2019) Absent or excessive corpus luteum number is associated with altered maternal vascular health in early pregnancy. Hypertension 73(3):680–690CrossRef

64.

von Versen-Höynck F, Strauch NK, Liu J et al (2019) Effect of mode of conception on maternal serum relaxin, creatinine, and sodium concentrations in an infertile population. Reprod Sci 26:412–419CrossRef

65.

Conrad KP, Lingis M, Sautina L et al (2020) Maternal endothelial function, circulating endothelial cells, and endothelial progenitor cells in pregnancies conceived with or without in vitro fertilization. Am J Physiol Regul Integr Comp Physiol 318(6):R1091–R1102PubMedPubMedCentralCrossRef

66.

Guan Y, Fan H, Styer AK et al (2016) A modified natural cycle results in higher live birth rate in vitrified-thawed embryo transfer for women with regular menstruation. Syst Biol Reprod Med 62(5):335–342PubMedCrossRef

Titel: Corpus luteum, vaskuläre Gesundheit und Präeklampsierisiko nach ART
verfasst von: Christian Trautmann
Prof. Dr. med. Frauke von Versen-Höynck, M.Sc.
Publikationsdatum: 01.07.2021
Verlag: Springer Vienna
Erschienen in: Gynäkologie in der Praxis / Ausgabe 3/2021
Print ISSN: 3005-0758
Elektronische ISSN: 3005-0766
DOI: https://doi.org/10.1007/s41974-021-00191-x

Springer Medizin Österreich

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