Skip to main content
main-content

Tipp

Weitere Artikel dieser Ausgabe durch Wischen aufrufen

Erschienen in: Journal für Gynäkologische Endokrinologie/Österreich 3/2021

01.07.2021 | Originalien

Corpus luteum, vaskuläre Gesundheit und Präeklampsierisiko nach ART

verfasst von: Christian Trautmann, M.Sc. Prof. Dr. med. Frauke von Versen-Höynck

Erschienen in: Journal für Gynäkologische Endokrinologie/Österreich | Ausgabe 3/2021

Einloggen, um Zugang zu erhalten
share
TEILEN

Zusammenfassung

Die maternale perikonzeptionelle Gesundheit als auch die Gesundheit in der Frühschwangerschaft bestimmen das Risiko für die Entwicklung einer Präeklampsie mit. Hierbei kommt insbesondere im Rahmen der assistierten Reproduktion dem Corpus luteum und dessen vasoaktiven Sekretionsprodukten, wie dem Relaxin, eine Bedeutung zu. Dieser Artikel beschreibt mögliche Zusammenhänge zwischen der Corpus-luteum-Anzahl, der maternalen Gefäßgesundheit und dem Präeklampsierisiko. Dabei wird insbesondere auf das Fehlen des Corpus luteum bei artifiziellen Auftauzyklen eingegangen, die neben einer gestörten maternalen kardiovaskulären Adaptation in der Frühschwangerschaft mit einem erhöhten Präeklampsierisiko einhergehen können.
Literatur
1.
Zurück zum Zitat Burton GJ, Redman CW, Roberts JM et al (2019) Pre-eclampsia: pathophysiology and clinical implications. BMJ 366:l2381 PubMedCrossRef Burton GJ, Redman CW, Roberts JM et al (2019) Pre-eclampsia: pathophysiology and clinical implications. BMJ 366:l2381 PubMedCrossRef
2.
Zurück zum Zitat Abalos E, Cuesta C, Grosso AL et al (2013) Global and regional estimates of preeclampsia and eclampsia: a systematic review. Eur J Obstet Gynecol Reprod Biol 170(1):1–7 PubMedCrossRef Abalos E, Cuesta C, Grosso AL et al (2013) Global and regional estimates of preeclampsia and eclampsia: a systematic review. Eur J Obstet Gynecol Reprod Biol 170(1):1–7 PubMedCrossRef
3.
Zurück zum Zitat Ebisch IM, Thomas CM, Wetzels AM et al (2008) Review of the role of the plasminogen activator system and vascular endothelial growth factor in subfertility. Fertil Steril 90(6):2340–2350 PubMedCrossRef Ebisch IM, Thomas CM, Wetzels AM et al (2008) Review of the role of the plasminogen activator system and vascular endothelial growth factor in subfertility. Fertil Steril 90(6):2340–2350 PubMedCrossRef
4.
Zurück zum Zitat Kampfer C, Saller S, Windschuttl S et al (2014) Pigment-Epithelium Derived Factor (PEDF) and the human ovary: a role in the generation of ROS in granulosa cells. Life Sci 97(2):129–136 PubMedCrossRef Kampfer C, Saller S, Windschuttl S et al (2014) Pigment-Epithelium Derived Factor (PEDF) and the human ovary: a role in the generation of ROS in granulosa cells. Life Sci 97(2):129–136 PubMedCrossRef
5.
Zurück zum Zitat Conrad KP (2011) Emerging role of relaxin in the maternal adaptations to normal pregnancy: implications for preeclampsia. Semin Nephrol 31(1):15–32 PubMedPubMedCentralCrossRef Conrad KP (2011) Emerging role of relaxin in the maternal adaptations to normal pregnancy: implications for preeclampsia. Semin Nephrol 31(1):15–32 PubMedPubMedCentralCrossRef
6.
Zurück zum Zitat Emmi AM, Skurnick J, Goldsmith LT et al (1991) Ovarian control of pituitary hormone secretion in early human pregnancy. J Clin Endocrinol Metab 72(6):1359–1369 PubMedCrossRef Emmi AM, Skurnick J, Goldsmith LT et al (1991) Ovarian control of pituitary hormone secretion in early human pregnancy. J Clin Endocrinol Metab 72(6):1359–1369 PubMedCrossRef
7.
Zurück zum Zitat Devoto L, Fuentes A, Kohen P et al (2009) The human corpus luteum: life cycle and function in natural cycles. Fertil Steril 92(3):1067–1079 PubMedCrossRef Devoto L, Fuentes A, Kohen P et al (2009) The human corpus luteum: life cycle and function in natural cycles. Fertil Steril 92(3):1067–1079 PubMedCrossRef
9.
Zurück zum Zitat Schock H, Zeleniuch-Jacquotte A, Lundin E et al (2016) Hormone concentrations throughout uncomplicated pregnancies: a longitudinal study. BMC Pregnancy Childbirth 16(1):146 PubMedPubMedCentralCrossRef Schock H, Zeleniuch-Jacquotte A, Lundin E et al (2016) Hormone concentrations throughout uncomplicated pregnancies: a longitudinal study. BMC Pregnancy Childbirth 16(1):146 PubMedPubMedCentralCrossRef
10.
Zurück zum Zitat Byers MJ, Zangl A, Phernetton TM et al (2005) Endothelial vasodilator production by ovine uterine and systemic arteries: ovarian steroid and pregnancy control of ERalpha and ERbeta levels. J Physiol 565(Pt 1):85–99 PubMedPubMedCentralCrossRef Byers MJ, Zangl A, Phernetton TM et al (2005) Endothelial vasodilator production by ovine uterine and systemic arteries: ovarian steroid and pregnancy control of ERalpha and ERbeta levels. J Physiol 565(Pt 1):85–99 PubMedPubMedCentralCrossRef
11.
Zurück zum Zitat Young SL, Savaris RF, Lessey BA et al (2017) Effect of randomized serum progesterone concentration on secretory endometrial histologic development and gene expression. Hum Reprod 32(9):1903–1914 PubMedPubMedCentralCrossRef Young SL, Savaris RF, Lessey BA et al (2017) Effect of randomized serum progesterone concentration on secretory endometrial histologic development and gene expression. Hum Reprod 32(9):1903–1914 PubMedPubMedCentralCrossRef
12.
Zurück zum Zitat Simoncini T, Fu XD, Caruso A et al (2007) Drospirenone increases endothelial nitric oxide synthesis via a combined action on progesterone and mineralocorticoid receptors. Hum Reprod 22(8):2325–2334 PubMedCrossRef Simoncini T, Fu XD, Caruso A et al (2007) Drospirenone increases endothelial nitric oxide synthesis via a combined action on progesterone and mineralocorticoid receptors. Hum Reprod 22(8):2325–2334 PubMedCrossRef
13.
Zurück zum Zitat Hermenegildo C, Oviedo PJ, García-Martínez MC et al (2005) Progestogens stimulate prostacyclin production by human endothelial cells. Hum Reprod 20(6):1554–1561 PubMedCrossRef Hermenegildo C, Oviedo PJ, García-Martínez MC et al (2005) Progestogens stimulate prostacyclin production by human endothelial cells. Hum Reprod 20(6):1554–1561 PubMedCrossRef
14.
Zurück zum Zitat Conrad KP (2020) Evidence for corpus luteal and endometrial origins of adverse pregnancy outcomes in women conceiving with or without assisted reproduction. Obstet Gynecol Clin North Am 47(1):163–181 PubMedPubMedCentralCrossRef Conrad KP (2020) Evidence for corpus luteal and endometrial origins of adverse pregnancy outcomes in women conceiving with or without assisted reproduction. Obstet Gynecol Clin North Am 47(1):163–181 PubMedPubMedCentralCrossRef
17.
Zurück zum Zitat Sherwood OD (2004) Relaxin’s physiological roles and other diverse actions. Endocr Rev 25(2):205–234 PubMedCrossRef Sherwood OD (2004) Relaxin’s physiological roles and other diverse actions. Endocr Rev 25(2):205–234 PubMedCrossRef
18.
Zurück zum Zitat Wiegel RE, Danser AHJ, Steegers-Theunissen RP et al (2020) Determinants of maternal renin-angiotensin-aldosterone-system activation in early pregancy: insights from 2 cohorts. J Clin Endocrinol Metab 105(11):1–13 CrossRef Wiegel RE, Danser AHJ, Steegers-Theunissen RP et al (2020) Determinants of maternal renin-angiotensin-aldosterone-system activation in early pregancy: insights from 2 cohorts. J Clin Endocrinol Metab 105(11):1–13 CrossRef
19.
Zurück zum Zitat Itskovitz J, Sealey JE (1987) Ovarian prorenin-renin-angiotensin system. Obstet Gynecol Surv 42(9):545–551 PubMedCrossRef Itskovitz J, Sealey JE (1987) Ovarian prorenin-renin-angiotensin system. Obstet Gynecol Surv 42(9):545–551 PubMedCrossRef
20.
Zurück zum Zitat Speth RC, Daubert DL, Grove KL (1999) Angiotensin II: a reproductive hormone too? Regul Pept 79(1):25–40 PubMedCrossRef Speth RC, Daubert DL, Grove KL (1999) Angiotensin II: a reproductive hormone too? Regul Pept 79(1):25–40 PubMedCrossRef
21.
Zurück zum Zitat Yoshimura Y (1997) The ovarian renin-angiotensin system in reproductive physiology. Front Neuroendocrinol 18(3):247–291 PubMedCrossRef Yoshimura Y (1997) The ovarian renin-angiotensin system in reproductive physiology. Front Neuroendocrinol 18(3):247–291 PubMedCrossRef
22.
Zurück zum Zitat Conrad KP, Baker VL (2013) Corpus luteal contribution to maternal pregnancy physiology and outcomes in assisted reproductive technologies. Am J Physiol Regul Integr Comp Physiol 304(2):R69–R72 PubMedCrossRef Conrad KP, Baker VL (2013) Corpus luteal contribution to maternal pregnancy physiology and outcomes in assisted reproductive technologies. Am J Physiol Regul Integr Comp Physiol 304(2):R69–R72 PubMedCrossRef
23.
Zurück zum Zitat Conrad KP, Graham GM, Chi YY et al (2019) Potential influence of the corpus luteum on circulating reproductive and volume regulatory hormones, angiogenic and immunoregulatory factors in pregnant women. Am J Physiol Endocrinol Metab 317(4):E677–E685 PubMedPubMedCentralCrossRef Conrad KP, Graham GM, Chi YY et al (2019) Potential influence of the corpus luteum on circulating reproductive and volume regulatory hormones, angiogenic and immunoregulatory factors in pregnant women. Am J Physiol Endocrinol Metab 317(4):E677–E685 PubMedPubMedCentralCrossRef
24.
Zurück zum Zitat von Versen-Höynck F, Hackl S, Selamet Tierney ES et al (2020) Maternal vascular health in pregnancy and postpartum after assisted reproduction. Hypertension 75(2):549–560 CrossRef von Versen-Höynck F, Hackl S, Selamet Tierney ES et al (2020) Maternal vascular health in pregnancy and postpartum after assisted reproduction. Hypertension 75(2):549–560 CrossRef
25.
Zurück zum Zitat Khaw A, Kametas NA, Turan OM et al (2008) Maternal cardiac function and uterine artery Doppler at 11–14 weeks in the prediction of pre-eclampsia in nulliparous women. BJOG 115(3):369–376 PubMedCrossRef Khaw A, Kametas NA, Turan OM et al (2008) Maternal cardiac function and uterine artery Doppler at 11–14 weeks in the prediction of pre-eclampsia in nulliparous women. BJOG 115(3):369–376 PubMedCrossRef
26.
Zurück zum Zitat De Paco C, Kametas N, Rencoret G et al (2008) Maternal cardiac output between 11 and 13 weeks of gestation in the prediction of preeclampsia and small for gestational age. Obstet Gynecol 111(2 Pt 1):292–300 PubMedCrossRef De Paco C, Kametas N, Rencoret G et al (2008) Maternal cardiac output between 11 and 13 weeks of gestation in the prediction of preeclampsia and small for gestational age. Obstet Gynecol 111(2 Pt 1):292–300 PubMedCrossRef
27.
Zurück zum Zitat Salas SP, Marshall G, Gutierrez BL et al (2006) Time course of maternal plasma volume and hormonal changes in women with preeclampsia or fetal growth restriction. Hypertension 47(2):203–208 PubMedCrossRef Salas SP, Marshall G, Gutierrez BL et al (2006) Time course of maternal plasma volume and hormonal changes in women with preeclampsia or fetal growth restriction. Hypertension 47(2):203–208 PubMedCrossRef
28.
Zurück zum Zitat Novak J, Danielson LA, Kerchner LJ et al (2001) Relaxin is essential for renal vasodilation during pregnancy in conscious rats. J Clin Invest 107(11):1469–1475 PubMedPubMedCentralCrossRef Novak J, Danielson LA, Kerchner LJ et al (2001) Relaxin is essential for renal vasodilation during pregnancy in conscious rats. J Clin Invest 107(11):1469–1475 PubMedPubMedCentralCrossRef
29.
Zurück zum Zitat Debrah DO, Novak J, Matthews JE et al (2006) Relaxin is essential for systemic vasodilation and increased global arterial compliance during early pregnancy in conscious rats. Endocrinology 147(11):5126–5131 PubMedCrossRef Debrah DO, Novak J, Matthews JE et al (2006) Relaxin is essential for systemic vasodilation and increased global arterial compliance during early pregnancy in conscious rats. Endocrinology 147(11):5126–5131 PubMedCrossRef
30.
31.
Zurück zum Zitat Chapman AB, Zamudio S, Woodmansee W et al (1997) Systemic and renal hemodynamic changes in the luteal phase of the menstrual cycle mimic early pregnancy. Am J Physiol 273(5 Pt 2):F777–F782 PubMed Chapman AB, Zamudio S, Woodmansee W et al (1997) Systemic and renal hemodynamic changes in the luteal phase of the menstrual cycle mimic early pregnancy. Am J Physiol 273(5 Pt 2):F777–F782 PubMed
32.
Zurück zum Zitat Petersen JW, Liu J, Chi YY et al (2017) Comparison of multiple non-invasive methods of measuring cardiac output during pregnancy reveals marked heterogeneity in the magnitude of cardiac output change between women. Physiol Rep 5(8):e13223 PubMedPubMedCentralCrossRef Petersen JW, Liu J, Chi YY et al (2017) Comparison of multiple non-invasive methods of measuring cardiac output during pregnancy reveals marked heterogeneity in the magnitude of cardiac output change between women. Physiol Rep 5(8):e13223 PubMedPubMedCentralCrossRef
33.
Zurück zum Zitat Jackson RA, Gibson KA, Wu YW et al (2004) Perinatal outcomes in singletons following in vitro fertilization: a meta-analysis. Obstet Gynecol 103(3):551–563 PubMedCrossRef Jackson RA, Gibson KA, Wu YW et al (2004) Perinatal outcomes in singletons following in vitro fertilization: a meta-analysis. Obstet Gynecol 103(3):551–563 PubMedCrossRef
34.
Zurück zum Zitat Helmerhorst FM, Perquin DA, Donker D et al (2004) Perinatal outcome of singletons and twins after assisted conception: a systematic review of controlled studies. BMJ 328(7434):261 PubMedPubMedCentralCrossRef Helmerhorst FM, Perquin DA, Donker D et al (2004) Perinatal outcome of singletons and twins after assisted conception: a systematic review of controlled studies. BMJ 328(7434):261 PubMedPubMedCentralCrossRef
35.
Zurück zum Zitat Maman E, Lunenfeld E, Levy A et al (1998) Obstetric outcome of singleton pregnancies conceived by in vitro fertilization and ovulation induction compared with those conceived spontaneously. Fertil Steril 70(2):240–245 PubMedCrossRef Maman E, Lunenfeld E, Levy A et al (1998) Obstetric outcome of singleton pregnancies conceived by in vitro fertilization and ovulation induction compared with those conceived spontaneously. Fertil Steril 70(2):240–245 PubMedCrossRef
36.
Zurück zum Zitat Pinborg A, Wennerholm UB, Romundstad LB et al (2013) Why do singletons conceived after assisted reproduction technology have adverse perinatal outcome? Systematic review and meta-analysis. Hum Reprod Update 19(2):87–104 PubMedCrossRef Pinborg A, Wennerholm UB, Romundstad LB et al (2013) Why do singletons conceived after assisted reproduction technology have adverse perinatal outcome? Systematic review and meta-analysis. Hum Reprod Update 19(2):87–104 PubMedCrossRef
37.
Zurück zum Zitat Salha O, Sharma V, Dada T et al (1999) The influence of donated gametes on the incidence of hypertensive disorders of pregnancy. Hum Reprod 14(9):2268–2273 PubMedCrossRef Salha O, Sharma V, Dada T et al (1999) The influence of donated gametes on the incidence of hypertensive disorders of pregnancy. Hum Reprod 14(9):2268–2273 PubMedCrossRef
38.
Zurück zum Zitat Sites CK, Wilson D, Barsky M et al (2017) Embryo cryopreservation and preeclampsia risk. Fertil Steril 108(5):784–790 PubMedCrossRef Sites CK, Wilson D, Barsky M et al (2017) Embryo cryopreservation and preeclampsia risk. Fertil Steril 108(5):784–790 PubMedCrossRef
39.
Zurück zum Zitat Barsky M, Marie StP, Rahil T et al (2016) Are perinatal outcomes affected by blastocyst vitrification and warming? Am J Obstet Gynecol 215(5):603e1–603e5 CrossRef Barsky M, Marie StP, Rahil T et al (2016) Are perinatal outcomes affected by blastocyst vitrification and warming? Am J Obstet Gynecol 215(5):603e1–603e5 CrossRef
40.
Zurück zum Zitat Chen ZJ, Shi Y, Sun Y et al (2016) Fresh versus frozen embryos for infertility in the polycystic ovary syndrome. N Engl J Med 375(6):523–533 PubMedCrossRef Chen ZJ, Shi Y, Sun Y et al (2016) Fresh versus frozen embryos for infertility in the polycystic ovary syndrome. N Engl J Med 375(6):523–533 PubMedCrossRef
41.
Zurück zum Zitat Sazonova A, Kallen K, Thurin-Kjellberg A et al (2012) Obstetric outcome in singletons after in vitro fertilization with cryopreserved/thawed embryos. Hum Reprod 27(5):1343–1350 PubMedCrossRef Sazonova A, Kallen K, Thurin-Kjellberg A et al (2012) Obstetric outcome in singletons after in vitro fertilization with cryopreserved/thawed embryos. Hum Reprod 27(5):1343–1350 PubMedCrossRef
42.
Zurück zum Zitat Wei D, Liu JY, Sun Y et al (2019) Frozen versus fresh single blastocyst transfer in ovulatory women: a multicentre, randomised controlled trial. Lancet 393(10178):1310–1318 PubMedCrossRef Wei D, Liu JY, Sun Y et al (2019) Frozen versus fresh single blastocyst transfer in ovulatory women: a multicentre, randomised controlled trial. Lancet 393(10178):1310–1318 PubMedCrossRef
43.
Zurück zum Zitat Roque M, Haahr T, Geber S et al (2019) Fresh versus elective frozen embryo transfer in IVF/ICSI cycles: a systematic review and meta-analysis of reproductive outcomes. Hum Reprod Update 25(1):2–14 PubMedCrossRef Roque M, Haahr T, Geber S et al (2019) Fresh versus elective frozen embryo transfer in IVF/ICSI cycles: a systematic review and meta-analysis of reproductive outcomes. Hum Reprod Update 25(1):2–14 PubMedCrossRef
44.
Zurück zum Zitat Saito K, Kuwahara A, Ishikawa T et al (2019) Endometrial preparation methods for frozen-thawed embryo transfer are associated with altered risks of hypertensive disorders of pregnancy, placenta accreta, and gestational diabetes mellitus. Hum Reprod 34(8):1567–1575 PubMedCrossRef Saito K, Kuwahara A, Ishikawa T et al (2019) Endometrial preparation methods for frozen-thawed embryo transfer are associated with altered risks of hypertensive disorders of pregnancy, placenta accreta, and gestational diabetes mellitus. Hum Reprod 34(8):1567–1575 PubMedCrossRef
45.
Zurück zum Zitat Ishihara O, Araki R, Kuwahara A et al (2014) Impact of frozen-thawed single-blastocyst transfer on maternal and neonatal outcome: an analysis of 277,042 single-embryo transfer cycles from 2008 to 2010 in Japan. Fertil Steril 101(1):128–133 PubMedCrossRef Ishihara O, Araki R, Kuwahara A et al (2014) Impact of frozen-thawed single-blastocyst transfer on maternal and neonatal outcome: an analysis of 277,042 single-embryo transfer cycles from 2008 to 2010 in Japan. Fertil Steril 101(1):128–133 PubMedCrossRef
46.
Zurück zum Zitat Ginstrom Ernstad E, Wennerholm UB, Khatibi A et al (2019) Neonatal and maternal outcome after frozen embryo transfer: Increased risks in programmed cycles. Am J Obstet Gynecol 221(2):126e1–126e18 CrossRef Ginstrom Ernstad E, Wennerholm UB, Khatibi A et al (2019) Neonatal and maternal outcome after frozen embryo transfer: Increased risks in programmed cycles. Am J Obstet Gynecol 221(2):126e1–126e18 CrossRef
47.
Zurück zum Zitat Lin J, Zhao J, Hao G et al (2020) Maternal and neonatal complications after natural vs. Hormone replacement therapy cycle regimen for frozen single Blastocyst transfer. Front Med 7:338 CrossRef Lin J, Zhao J, Hao G et al (2020) Maternal and neonatal complications after natural vs. Hormone replacement therapy cycle regimen for frozen single Blastocyst transfer. Front Med 7:338 CrossRef
48.
Zurück zum Zitat Opdahl S, Henningsen AA, Tiitinen A et al (2015) Risk of hypertensive disorders in pregnancies following assisted reproductive technology: a cohort study from the CoNARTaS group. Hum Reprod 30(7):1724–1731 PubMedCrossRef Opdahl S, Henningsen AA, Tiitinen A et al (2015) Risk of hypertensive disorders in pregnancies following assisted reproductive technology: a cohort study from the CoNARTaS group. Hum Reprod 30(7):1724–1731 PubMedCrossRef
49.
Zurück zum Zitat Maheshwari A, Pandey S, Amalraj Raja E et al (2018) Is frozen embryo transfer better for mothers and babies? Can cumulative meta-analysis provide a definitive answer? Hum Reprod Update 24(1):35–58 PubMedCrossRef Maheshwari A, Pandey S, Amalraj Raja E et al (2018) Is frozen embryo transfer better for mothers and babies? Can cumulative meta-analysis provide a definitive answer? Hum Reprod Update 24(1):35–58 PubMedCrossRef
50.
Zurück zum Zitat Sha T, Yin X, Cheng W et al (2018) Pregnancy-related complications and perinatal outcomes resulting from transfer of cryopreserved versus fresh embryos in vitro fertilization: a meta-analysis. Fertil Steril 109(2):330–342.e9 PubMedCrossRef Sha T, Yin X, Cheng W et al (2018) Pregnancy-related complications and perinatal outcomes resulting from transfer of cryopreserved versus fresh embryos in vitro fertilization: a meta-analysis. Fertil Steril 109(2):330–342.e9 PubMedCrossRef
51.
Zurück zum Zitat Yang M, Lin L, Sha C et al (2020) Which is better for mothers and babies: fresh or frozen-thawed blastocyst transfer? BMC Pregnancy Childbirth 20(1):559 PubMedPubMedCentralCrossRef Yang M, Lin L, Sha C et al (2020) Which is better for mothers and babies: fresh or frozen-thawed blastocyst transfer? BMC Pregnancy Childbirth 20(1):559 PubMedPubMedCentralCrossRef
52.
Zurück zum Zitat Wang B, Zhang J, Zhu Q et al (2020) Effects of different cycle regimens for frozen embryo transfer on perinatal outcomes of singletons. Hum Reprod 35(7):1612–1622 PubMedCrossRef Wang B, Zhang J, Zhu Q et al (2020) Effects of different cycle regimens for frozen embryo transfer on perinatal outcomes of singletons. Hum Reprod 35(7):1612–1622 PubMedCrossRef
53.
Zurück zum Zitat Zong L, Liu P, Zhou L et al (2020) Increased risk of maternal and neonatal complications in hormone replacement therapy cycles in frozen embryo transfer. Reprod Biol Endocrinol 18(1):36 PubMedPubMedCentralCrossRef Zong L, Liu P, Zhou L et al (2020) Increased risk of maternal and neonatal complications in hormone replacement therapy cycles in frozen embryo transfer. Reprod Biol Endocrinol 18(1):36 PubMedPubMedCentralCrossRef
54.
Zurück zum Zitat Asserhøj LL, Spangmose AL, Aaris Henningsen AK et al (2021) Adverse obstetric and perinatal outcomes in 1,136 singleton pregnancies conceived after programmed frozen embryo transfer (FET) compared with natural cycle FET. Fertil Steril 115(4):947–956 PubMedCrossRef Asserhøj LL, Spangmose AL, Aaris Henningsen AK et al (2021) Adverse obstetric and perinatal outcomes in 1,136 singleton pregnancies conceived after programmed frozen embryo transfer (FET) compared with natural cycle FET. Fertil Steril 115(4):947–956 PubMedCrossRef
55.
Zurück zum Zitat Makhijani R, Bartels C, Godiwala P et al (2020) Maternal and perinatal outcomes in programmed versus natural vitrified-warmed blastocyst transfer cycles. Reprod Biomed Online 41(2):300–308 PubMedCrossRef Makhijani R, Bartels C, Godiwala P et al (2020) Maternal and perinatal outcomes in programmed versus natural vitrified-warmed blastocyst transfer cycles. Reprod Biomed Online 41(2):300–308 PubMedCrossRef
58.
Zurück zum Zitat Zaat TR, Brink AJ, de Bruin JP et al (2021) Increased obstetric and neonatal risks in artificial cycles for frozen embryo transfers? Reprod Biomed Online 42(5):919–929 PubMedCrossRef Zaat TR, Brink AJ, de Bruin JP et al (2021) Increased obstetric and neonatal risks in artificial cycles for frozen embryo transfers? Reprod Biomed Online 42(5):919–929 PubMedCrossRef
59.
Zurück zum Zitat von Versen-Höynck F, Schaub AM, Chi YY et al (2019) Increased preeclampsia risk and reduced aortic compliance with in vitro fertilization cycles in the absence of a corpus luteum. Hypertension 73(3):640–649 CrossRef von Versen-Höynck F, Schaub AM, Chi YY et al (2019) Increased preeclampsia risk and reduced aortic compliance with in vitro fertilization cycles in the absence of a corpus luteum. Hypertension 73(3):640–649 CrossRef
60.
Zurück zum Zitat Wang Z, Liu H, Song H et al (2020) Increased risk of pre-eclampsia after frozen-thawed embryo transfer in programming cycles. Front Med 7:104 CrossRef Wang Z, Liu H, Song H et al (2020) Increased risk of pre-eclampsia after frozen-thawed embryo transfer in programming cycles. Front Med 7:104 CrossRef
61.
Zurück zum Zitat Roelens C, Racca A, Mackens S et al (2020) Artificially prepared frozen embryo transfer cycles are associated with an increased risk of preeclampsia. Hum Reprod 35:108–109 (In: 36th Annual Meeting of ESHRE) Roelens C, Racca A, Mackens S et al (2020) Artificially prepared frozen embryo transfer cycles are associated with an increased risk of preeclampsia. Hum Reprod 35:108–109 (In: 36th Annual Meeting of ESHRE)
62.
Zurück zum Zitat Conrad KP, Petersen JW, Chi YY et al (2019) Maternal cardiovascular dysregulation during early pregnancy after in vitro fertilization cycles in the absence of a corpus luteum. Hypertension 74(3):705–715 PubMedCrossRef Conrad KP, Petersen JW, Chi YY et al (2019) Maternal cardiovascular dysregulation during early pregnancy after in vitro fertilization cycles in the absence of a corpus luteum. Hypertension 74(3):705–715 PubMedCrossRef
63.
Zurück zum Zitat von Versen-Höynck F, Narasimhan P, Selamet Tierney ES et al (2019) Absent or excessive corpus luteum number is associated with altered maternal vascular health in early pregnancy. Hypertension 73(3):680–690 CrossRef von Versen-Höynck F, Narasimhan P, Selamet Tierney ES et al (2019) Absent or excessive corpus luteum number is associated with altered maternal vascular health in early pregnancy. Hypertension 73(3):680–690 CrossRef
64.
Zurück zum Zitat von Versen-Höynck F, Strauch NK, Liu J et al (2019) Effect of mode of conception on maternal serum relaxin, creatinine, and sodium concentrations in an infertile population. Reprod Sci 26:412–419 CrossRef von Versen-Höynck F, Strauch NK, Liu J et al (2019) Effect of mode of conception on maternal serum relaxin, creatinine, and sodium concentrations in an infertile population. Reprod Sci 26:412–419 CrossRef
65.
Zurück zum Zitat Conrad KP, Lingis M, Sautina L et al (2020) Maternal endothelial function, circulating endothelial cells, and endothelial progenitor cells in pregnancies conceived with or without in vitro fertilization. Am J Physiol Regul Integr Comp Physiol 318(6):R1091–R1102 PubMedPubMedCentralCrossRef Conrad KP, Lingis M, Sautina L et al (2020) Maternal endothelial function, circulating endothelial cells, and endothelial progenitor cells in pregnancies conceived with or without in vitro fertilization. Am J Physiol Regul Integr Comp Physiol 318(6):R1091–R1102 PubMedPubMedCentralCrossRef
66.
Zurück zum Zitat Guan Y, Fan H, Styer AK et al (2016) A modified natural cycle results in higher live birth rate in vitrified-thawed embryo transfer for women with regular menstruation. Syst Biol Reprod Med 62(5):335–342 PubMedCrossRef Guan Y, Fan H, Styer AK et al (2016) A modified natural cycle results in higher live birth rate in vitrified-thawed embryo transfer for women with regular menstruation. Syst Biol Reprod Med 62(5):335–342 PubMedCrossRef
Metadaten
Titel
Corpus luteum, vaskuläre Gesundheit und Präeklampsierisiko nach ART
verfasst von
Christian Trautmann
M.Sc. Prof. Dr. med. Frauke von Versen-Höynck
Publikationsdatum
01.07.2021
Verlag
Springer Vienna
Erschienen in
Journal für Gynäkologische Endokrinologie/Österreich / Ausgabe 3/2021
Print ISSN: 1997-6690
Elektronische ISSN: 1996-1553
DOI
https://doi.org/10.1007/s41974-021-00191-x